DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and arm

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001259149.1	Gene:	arm / 31151	FlyBaseID:	FBgn0000117	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	146/748 - (19%)
Similarity:	245/748 - (32%)	Gaps:	266/748 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GAITKVAPHCSQNKIE----------------TNSTDNSIPDIENHPLATTVRYVQAGQYEDTSE 113
            ||:|:| |..|..:.|                .|.|.:.:.|:......|..:.|:|..:.:|.|
  Fly    49 GAVTQV-PSLSGKEDEEMEGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQTRSQRVRAAMFPETLE 112

  Fly   114 YGVAGLTCGID-------------SEYTAEAVVPYC-YTSDANYTGIQNTTSSIKPFSGRPFNDN 164
            .|:...:...|             |:....|||... |..||     :..|.:| |...:..||.
  Fly   113 EGIEIPSTQFDPQQPTAVQRLSEPSQMLKHAVVNLINYQDDA-----ELATRAI-PELIKLLNDE 171

  Fly   165 INGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMR-------- 221
                :.|..||..........|  :.:..:|...||.:......|..| ||:.||..
  Fly   172 ----DQVVVSQAAMMVHQLSKK--EASRHAIMNSPQMVAALVRAISNS-NDLESTKAAVGTLHNL 229

  Fly   222 ----------WRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLL 276
                      ::...:..::..||:|..::...|...|.:|....|.:|...|..||:..:|.||
  Fly   230 SHHRQGLLAIFKSGGIPALVKLLSSPVESVLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLL 294

  Fly   277 SYDSPEIHKNACGALRNLSYGRQNDE--------------------------------------- 302
            ..::.:........|:.|:||.|..:
  Fly   295 QRNNVKFLAIVTDCLQILAYGNQESKLIILASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCS 359

  Fly   303 -NKRGIKNAGGIAAL-VHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPH 365
             ||..|.:|||:.|| :||...|     ..||...||.:.:..|....:  |.|.|::.|:::..
  Fly   360 SNKPAIVDAGGMQALAMHLGNMS-----PRLVQNCLWTLRNLSDAATKV--EGLEALLQSLVQVL 417

  Fly   366 SGWD--AVCCGETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGN 428
            ...|  .|.|           |:|:|.|::...:..:..:  |:  |..:..:|||.|   |.|:
  Fly   418 GSTDVNVVTC-----------AAGILSNLTCNNQRNKATV--CQ--VGGVDALVRTII---NAGD 464

  Fly   429 K--TVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDA 491
            :  ..|..||.||:|:.|
  Fly   465 REEITEPAVCALRHLTSR----------------------------------------------- 482

  Fly   492 LNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSAC--- 553
                ::.::.::::|   :||.|         :...:.||...|....::|..|.|:||:.|
  Fly   483 ----HVDSELAQNAV---RLNYG---------LSVIVKLLHPPSRWPLIKAVIGLIRNLALCPAN 531

  Fly   554 -----------------------------------YWQPS------------------IDI---- 561
                                               ..|||                  :.|
  Fly   532 HAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIVEGTVGALHILARE 596

  Fly   562 ---RATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNV 623
               ||.:|::..:||.|.||..|::.:....|..|..||.|:...|:|.:.....     |..::
  Fly   597 SHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEGATG-----PLTDL 656

  Fly   624 QHDQNTSDDT-ITAVLATINEVIKKNPEFSRSL 655
            .|.:|....| ..|||..::|  .|..::.:.|
  Fly   657 LHSRNEGVATYAAAVLFRMSE--DKPQDYKKRL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	34/154 (22%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	14/35 (40%)
		ARM	307..442	CDD:237987	38/139 (27%)
		armadillo repeat	347..392	CDD:293788	10/46 (22%)
		armadillo repeat	515..556	CDD:293788	9/78 (12%)
		ARM	516..643	CDD:237987	36/190 (19%)
		armadillo repeat	562..596	CDD:293788	11/33 (33%)
		armadillo repeat	601..641	CDD:293788	9/40 (23%)
arm	NP_001259149.1	Adaptin_N	<150..>314	CDD:331138	37/176 (21%)
		armadillo repeat	161..186	CDD:293788	7/29 (24%)
		armadillo repeat	193..231	CDD:293788	9/38 (24%)
		armadillo repeat	238..270	CDD:293788	5/31 (16%)
		armadillo repeat	278..314	CDD:293788	9/35 (26%)
		armadillo repeat	320..355	CDD:293788	0/34 (0%)
		Arm	361..398	CDD:278915	15/41 (37%)
		armadillo repeat	362..397	CDD:293788	14/39 (36%)
		armadillo repeat	410..435	CDD:293788	7/35 (20%)
		Arm	439..481	CDD:278915	14/48 (29%)
		armadillo repeat	443..481	CDD:293788	14/44 (32%)
		armadillo repeat	490..525	CDD:293788	10/46 (22%)
		Arm	597..636	CDD:278915	12/38 (32%)
		armadillo repeat	600..636	CDD:293788	12/35 (34%)
		armadillo repeat	641..675	CDD:293788	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940