DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ctnnb1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_005157888.1	Gene:	ctnnb1 / 30265	ZFINID:	ZDB-GENE-980526-362	Length:	789	Species:	Danio rerio

Alignment Length:	884	Identity:	167/884 - (18%)
Similarity:	300/884 - (33%)	Gaps:	277/884 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MDLSLTHEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDN 86
            |:|.:..:|             |:.:|..:.....|:......||.|.......:...|.:..||
Zfish     8 MELEMAMDP-------------DRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEDDDVDN 59

  Fly    87 -----------------SIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEA--- 131
                             .:.||:.....|..:.|:|..:.:|.:.|:...:...||.:....
Zfish    60 QVLYEWEQGFNQSFNQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDSAHPTNVQRL 124

  Fly   132 -----VVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDN----INGAEAVADSQCRTFKSS--AEF 185
                 ::.:...:..||.......:...|...:..||.    :|.| ||...|....::|  |..
Zfish   125 AEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKA-AVMVHQLSKKEASRHAIM 188

  Fly   186 KLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMR-------------------WRDPNLSEVI 231
            :.||...:.:.|:.            :.||: .|.|                   ::...:..::
Zfish   189 RSPQMVSAIVRTMQ------------NTNDV-ETARCTSGTLHNLSHHREGLLAIFKSGGIPALV 240

  Fly   232 SFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSY 296
            ..|.:|..::...|...|.:|....:..|...|..||:..:|.||:..:.:........|:.|:|
Zfish   241 KMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 305

  Fly   297 GRQNDE----------------------------------------NKRGIKNAGGIAAL-VHLL 320
            |.|..:                                        ||..|..|||:.|| :||.
Zfish   306 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLT 370

  Fly   321 CRSQETEVKELVTGVLW---NMSSCEDLKRSIID-------EALVAVVCSVIKPHSGWDAVCCGE 375
            ..||     .||...||   |:|.....:.|:.:       |.|:..:..::    |.|.:
Zfish   371 DPSQ-----RLVQNCLWTLRNLSDAATKQTSLAEVDVQEGMEGLLGTLVQLL----GSDDI---- 422

  Fly   376 TCFSTVFRNASGVLRNVSSAGEHARGCLRNCE-HLVECLLYVVRTSIEKNNIGNKTVENCVCILR 439
                .|...|:|:|.|::.  .:.:..:..|: ..:|.|:..|..:.::.:|    .|..:|.||
Zfish   423 ----NVVTCAAGILSNLTC--NNYKNKMMVCQVGGIEALVRTVLRAGDREDI----TEPAICALR 477

  Fly   440 NLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKS 504
            :|:.|.|:                                                   |:.:::
Zfish   478 HLTSRHQD---------------------------------------------------AEMAQN 491

  Fly   505 SVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEK 569
            :|   :|:.|.     |.||:    ||...|:...::|..|.|:||:.|   |:  ..|.:|::.
Zfish   492 AV---RLHYGL-----PVVVK----LLHPPSHWPLIKATVGLIRNLALC---PA--NHAPLREQG 539

  Fly   570 GLPILVELL------------------------RMEVDRVVCAVATALRNLAIDQRNKELI-GKY 609
            .:|.||:||                        |||  .:|.....||..||.|..|:.:| |..
Zfish   540 AIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRME--EIVEGCTGALHILARDIHNRIVIRGLN 602

  Fly   610 AMRDLVQKL--PSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKE 672
            .:...||.|  |..|:|.           |.|.:...:.::.|.:.::...|....|..:...:.
Zfish   603 TIPLFVQLLYSPIENIQR-----------VAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRN 656

  Fly   673 KYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMAS 737
            :   .|..:|:.||:.|.:.       |...:|::..|....:...|.|.:.|...: |...:.:
Zfish   657 E---GVATYAAAVLFRMSED-------KPQDYKKRLSVELTSSLFRTEPMTWNETGD-LGLDIGA 710

  Fly   738 QGRT---RYEDRTIQRGTSTLYSANDSSG--AVMSNESA 771
            ||..   |.:|.:.:...|..| ..|:.|  .:|.:|.|
Zfish   711 QGEPLGYRQDDPSYRSFHSGGY-GQDAMGMDPMMEHEMA 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	34/157 (22%)
		armadillo repeat	227..252	CDD:293788	4/24 (17%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	15/38 (39%)
		ARM	307..442	CDD:237987	35/146 (24%)
		armadillo repeat	347..392	CDD:293788	9/51 (18%)
		armadillo repeat	515..556	CDD:293788	12/40 (30%)
		ARM	516..643	CDD:237987	40/153 (26%)
		armadillo repeat	562..596	CDD:293788	13/57 (23%)
		armadillo repeat	601..641	CDD:293788	11/42 (26%)
ctnnb1	XP_005157888.1	ARM	<151..221	CDD:237987	17/83 (20%)
		armadillo repeat	152..177	CDD:293788	7/25 (28%)
		armadillo repeat	187..220	CDD:293788	7/45 (16%)
		ARM	228..347	CDD:237987	17/118 (14%)
		armadillo repeat	229..261	CDD:293788	4/31 (13%)
		armadillo repeat	269..305	CDD:293788	9/35 (26%)
		armadillo repeat	311..346	CDD:293788	0/34 (0%)
		ARM	349..389	CDD:214547	17/44 (39%)
		armadillo repeat	353..389	CDD:293788	16/40 (40%)
		ARM	407..526	CDD:237987	35/199 (18%)
		armadillo repeat	410..435	CDD:293788	6/36 (17%)
		armadillo repeat	443..481	CDD:293788	10/41 (24%)
		armadillo repeat	490..525	CDD:293788	12/46 (26%)
		ARM	492..631	CDD:237987	43/168 (26%)
		armadillo repeat	532..590	CDD:293788	14/59 (24%)
		armadillo repeat	595..629	CDD:293788	10/44 (23%)
		ARM	597..>676	CDD:237987	19/99 (19%)
		armadillo repeat	637..670	CDD:293788	6/35 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940