DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and Pkp4

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_006234278.1	Gene:	Pkp4 / 295625	RGDID:	1307840	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	315/835 - (37%)
Similarity:	431/835 - (51%)	Gaps:	165/835 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KHSLIGLNMNSTHINMDLSLT--HEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITK 69
            :||.:|.::.|. ::.||.:|  :|.....|......|:......| |.|.||.|...|:|.:.:
  Rat   408 QHSQLGQDLRSA-VSPDLHITPIYEGRTYYSPVYRSPNHGTVELQG-SQTALYRTGSVGIGNLQR 470

  Fly    70 VAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVP 134
            .:...|....:.|          |:.|.|...|                          ||...|
  Rat   471 TSSQRSTLTYQRN----------NYALNTAATY--------------------------AEPYRP 499

  Fly   135 YCYTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVP 199
            ..|.       :|..:.:..|.:| |.:|....:.::...|    |..:.||          .|.
  Rat   500 VQYR-------VQECSYNRLPHTG-PADDGATRSPSIDSIQ----KDPSTFK----------GVI 542

  Fly   200 QRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTR 264
            ..|:....:.|         ..||||.|.|||..|.:...:::|||||||||||:.|:..|....
  Rat   543 HCLQTSVVFWE---------FAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVY 598

  Fly   265 SLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVK 329
            .||||..||.||.:...|:.||||||||||.:|:..||||..:||.|||.||:.||.:|.:.||:
  Rat   599 RLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVR 663

  Fly   330 ELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCF----------STVFRN 384
            |||||||||:|||:.:|.:||.:||..:..:||.|||||:     ::.|          |.|.||
  Rat   664 ELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWN-----DSSFDDDHKIKFQTSLVLRN 723

  Fly   385 ASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQ--- 446
            .:|.|||:|||||.||..:|:||.||:.||||:.|.:..::..:||||||||.|||||||.:
  Rat   724 TTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEV 788

  Fly   447 ---------EVDD------PNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEAN-NSDALNEY 495
                     |:||      |:.|..|                 .|:|..||||:.. ..|..:..
  Rat   789 PQARLLGLNELDDLLGKESPSKDSEP-----------------SCWGKKKKKKKRTPQEDQWDGV 836

  Fly   496 NISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSID 560
            ......|||.       ||.|.||.|.||:.||:||...|||.|||.:||::|||||..|:.:..
  Rat   837 GPIPGLSKSP-------KGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAY 894

  Fly   561 IRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQH 625
            |||.||||||||||||||||:.||||.:|||||||:|:|.|||||||||||||||.:||.||  .
  Rat   895 IRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGN--G 957

  Fly   626 DQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITK-RKEKYTSCVLKFASQVLYTM 689
            ....||:|:.|:...::||..||.|.:::|.|||||::|:|||| |.::.:..|:|.|:|||.|:
  Rat   958 PSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTL 1022

  Fly   690 WQHNELRDVYKKNGWKEQDFVS-------KHFTAHNTPPSSPNN---------VNNTLNRPM--- 735
            ||:.:||.:|||:||.:..|::       ..|.:|  |..|..|         |.:|.:.|.
  Rat  1023 WQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSH--PSLSTTNQQMSPVIQSVGSTSSSPALLG 1085

  Fly   736 ASQGRTRYEDRT-------IQRGTST---LYSANDSSGAV-MSNESAMLSEMVRK 779
            ..:.|:.| |||       ..:|.:|   ||..:.....: :|:.|:...|..|:
  Rat  1086 IREPRSEY-DRTQPPMQYYNSQGDTTHKGLYPGSSKPSPIYISSYSSPAREQNRR 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	63/113 (56%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	20/35 (57%)
		armadillo repeat	304..339	CDD:293788	21/34 (62%)
		ARM	307..442	CDD:237987	73/144 (51%)
		armadillo repeat	347..392	CDD:293788	19/54 (35%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	79/126 (63%)
		armadillo repeat	562..596	CDD:293788	28/33 (85%)
		armadillo repeat	601..641	CDD:293788	23/39 (59%)
Pkp4	XP_006234278.1	PLN03209	<236..393	CDD:178748
		armadillo repeat	561..586	CDD:293788	13/24 (54%)
		Arm	590..629	CDD:395413	20/38 (53%)
		armadillo repeat	594..630	CDD:293788	20/35 (57%)
		ARM	634..675	CDD:214547	25/40 (63%)
		armadillo repeat	638..673	CDD:293788	21/34 (62%)
		armadillo repeat	680..731	CDD:293788	20/55 (36%)
		armadillo repeat	739..780	CDD:293788	21/40 (53%)
		Arm	845..886	CDD:395413	24/47 (51%)
		armadillo repeat	856..886	CDD:293788	17/29 (59%)
		PLN03200	879..>1000	CDD:215629	75/122 (61%)
		ARM	896..931	CDD:214547	29/34 (85%)
		armadillo repeat	898..930	CDD:293788	26/31 (84%)
		armadillo repeat	937..978	CDD:293788	23/42 (55%)
		ARM	980..1024	CDD:214547	21/43 (49%)
		armadillo repeat	984..1019	CDD:293788	16/34 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6212
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45523
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970