DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and Pkp3

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_008758204.1	Gene:	Pkp3 / 293619	RGDID:	1309133	Length:	836	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	210/816 - (25%)
Similarity:	357/816 - (43%)	Gaps:	186/816 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 MQSQFGS---FQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSI------ 88
            |||.|.|   ..:.|:.|.....:.|.|  .|....:.:.|...||:.....::..::.
  Rat    87 MQSGFSSRSQGMSGDKTSTFRPIAKPAY--NPASWSSRSAVDLTCSRRLSSAHNGGSAFGAVGYG 149

  Fly    89 -----PDIENHPLATTVRYVQAGQYEDTSEYGVAGLTC------GIDSEYT--AEAVVPYCYTSD 140
                 |.:...|    |.:.:.|.....::|....|..      |:|..|:  :|.:.|...::.
  Rat   150 GAQPTPPMPTRP----VSFHERGGAASRADYDTLSLRSLRLGPGGLDDRYSVVSEQLEPAAASTY 210

  Fly   141 ANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMS------------ 193
            ..|...:..:||.....|      ::..||......||.::.|...|.:|..|
  Rat   211 RAYAYERQASSSSSRAGG------LDWPEATEGPPSRTIRAPAMRTLQRFQSSHRSRGGTGSVSG 269

  Fly   194 ----------SINTVP------------------------QRLEEKDDYIEGSENDICSTMRW-- 222
                      |:.::.                        |||....|.|     |:.|.:::
  Rat   270 AGLEPVARAPSVRSLSLSLGDSGHLPDVRGLDSYTGHRTLQRLSSGFDDI-----DLPSAVKYLM 329

  Fly   223 -RDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKN 286
             .||||..:              .|||:||.||.|...|::.|||..:|.||:|.::.:.|:.::
  Rat   330 ASDPNLQVL--------------GAAYIQHRCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRH 380

  Fly   287 ACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIID 351
            |.||:|||.|  .|.:||..:....||..|:..| |.|:.|:::.|||:|||:||.:.||..:..
  Rat   381 ATGAMRNLIY--DNVDNKLALVEENGIFELLRTL-REQDDELRKNVTGILWNLSSSDHLKDRLAR 442

  Fly   352 EALVAVVCSVIKPHSGWDAVCCG-------ETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHL 409
            :.|..:...|:.|.||     .|       ....:.:|.||:|.|||:|||.:..|..:|.|..|
  Rat   443 DTLEQLTDLVLSPLSG-----AGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGL 502

  Fly   410 VECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERV-------IPS 467
            |:.|:..:..:::.....:|:|||.||:|||||||.       ||:.|....:|:       :..
  Rat   503 VDALVTYINHALDVGKCEDKSVENAVCVLRNLSYRL-------YDEMPPSALQRLEGRGRRDMAG 560

  Fly   468 SSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLN---KGYEQLWQPEVVQYYLS 529
            :..||.:|||....::        |.|..::||    ::|:.:::   ||.|.||.|::|..|..
  Rat   561 APPGEVVGCFTPQSRR--------LRELPLTAD----ALTFAEVSKDPKGLEWLWSPQIVGLYNR 613

  Fly   530 LLQSCS-NPETLEAAAGAIQNLSA--CYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVAT 591
            |||.|. |..|.||||||:||::|  ..|...:. |..:.:|:.|..|::.:|......:.::..
  Rat   614 LLQRCELNRHTTEAAAGALQNITAGDRRWAGVLS-RLALEQERILNPLLDRVRTADHNQLRSLTG 677

  Fly   592 ALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLL 656
            .:|||:.:.|||:.:....:..|::||| |:| .::....:.:..::|.:|.::..:|..:|.||
  Rat   678 LIRNLSRNARNKDEMSTKVVSHLIEKLP-GSV-GEKCPPAEVLVNIIAVLNNLVVASPIAARDLL 740

  Fly   657 DSGGIDRLMNITKRK-----EKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTA 716
            ...|:.:|:.|.|::     ||.:    :.||.:|..:||:::|          .:||.:..||
  Rat   741 YFDGLRKLVFIKKKRDSPDSEKSS----RAASSLLANLWQYSKL----------HRDFRAVCFT- 790

  Fly   717 HNTPPSSPNNVNNTLNRPMASQGRTRYEDRTIQRGT 752
                    .::|..|..      ..:|..:..:|||
  Rat   791 --------ESINGVLGH------EAQYRMQVTRRGT 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	41/113 (36%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	15/35 (43%)
		armadillo repeat	304..339	CDD:293788	13/34 (38%)
		ARM	307..442	CDD:237987	48/141 (34%)
		armadillo repeat	347..392	CDD:293788	12/51 (24%)
		armadillo repeat	515..556	CDD:293788	21/43 (49%)
		ARM	516..643	CDD:237987	40/129 (31%)
		armadillo repeat	562..596	CDD:293788	6/33 (18%)
		armadillo repeat	601..641	CDD:293788	10/39 (26%)
Pkp3	XP_008758204.1	ARM	321..432	CDD:237987	45/127 (35%)
		armadillo repeat	321..346	CDD:293788	9/38 (24%)
		armadillo repeat	354..390	CDD:293788	15/35 (43%)
		armadillo repeat	396..430	CDD:293788	13/34 (38%)
		ARM	397..535	CDD:237987	48/143 (34%)
		armadillo repeat	449..485	CDD:293788	11/40 (28%)
		armadillo repeat	493..534	CDD:293788	14/40 (35%)
		armadillo repeat	648..682	CDD:293788	6/33 (18%)
		ARM	649..776	CDD:237987	31/132 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810