DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and Pkp4

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_036016888.1	Gene:	Pkp4 / 227937	MGIID:	109281	Length:	1206	Species:	Mus musculus

Alignment Length:	836	Identity:	313/836 - (37%)
Similarity:	427/836 - (51%)	Gaps:	167/836 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KHSLIGLNMNSTHINMDLSLT--HEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITK 69
            :||.:|..:.|. ::.||.:|  :|.....|......|:......| |.|.||.|...|:|.:.:
Mouse   392 QHSQLGQELRSA-VSPDLHITPIYEGRTYYSPVYRSPNHGTVELQG-SQTALYRTGSVGIGNLQR 454

  Fly    70 VAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVP 134
            .:...|....:.|          |:.|.|...|                          ||...|
Mouse   455 TSSQRSTLTYQRN----------NYALNTAATY--------------------------AEPYRP 483

  Fly   135 YCY-TSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTV 198
            ..| ..:.:|..:|:|..:....:..|..|:|....:.........::|..|.  :||
Mouse   484 VQYRVQECSYNRLQHTGPADDGATRSPSIDSIQKDPSTLKGVIHCLQTSVVFW--EFA------- 539

  Fly   199 PQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRT 263
                                   ||||.|.|||..|.:...:::|||||||||||:.|:..|...
Mouse   540 -----------------------WRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEV 581

  Fly   264 RSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEV 328
            ..||||..||.||.:...|:.||||||||||.:|:..||||..:||.|||.||:.||.:|.:.||
Mouse   582 YRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEV 646

  Fly   329 KELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCF----------STVFR 383
            :|||||||||:|||:.:|.:||.:||..:..:||.|||||:     .:.|          |.|.|
Mouse   647 RELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWN-----NSSFDDDHKIKFQTSLVLR 706

  Fly   384 NASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQ-- 446
            |.:|.|||:|||||.||..:|:||.||:.||||:.|.:..::..:||||||||.|||||||.:
Mouse   707 NTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELE 771

  Fly   447 ----------EVDD------PNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEAN-NSDALNE 494
                      |:||      |:.|..|                 .|:|..||||:.. ..|..:.
Mouse   772 VPQARLLGLNELDDLLGKESPSKDSEP-----------------SCWGKKKKKKKRTPQEDQWDG 819

  Fly   495 YNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSI 559
            .......|||.       ||.|.||.|.||:.||:||...|||.|||.:||::|||||..|:.:.
Mouse   820 VGPIPGLSKSP-------KGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAA 877

  Fly   560 DIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQ 624
            .|||.||||||||||||||||:.||||.:|||||||:|:|.|||||||||||||||.:||.||
Mouse   878 YIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGN-- 940

  Fly   625 HDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITK-RKEKYTSCVLKFASQVLYT 688
            .....||:|:.|:...::||..||.|.:::|.|||||::|:|||| |.::.:..|:|.|:|||.|
Mouse   941 GPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNT 1005

  Fly   689 MWQHNELRDVYKKNGWKEQDFVS-------KHFTAHNTPPSSPNN---------VNNTLNRPM-- 735
            :||:.:||.:|||:||.:..|::       ..|.:|  |..|..|         |.:|.:.|.
Mouse  1006 LWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSH--PSLSTTNQQMSPIIQSVGSTSSSPALL 1068

  Fly   736 -ASQGRTRYEDRT-------IQRGTST---LYSANDSSGAV-MSNESAMLSEMVRK 779
             ..:.|:.| |||       ..:|.:|   ||..:.....: :|:.|:...|..|:
Mouse  1069 GIREPRSEY-DRTQPPMQYYNSQGDTTHKGLYPGSSKPSPIYISSYSSPAREQNRR 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	63/113 (56%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	20/35 (57%)
		armadillo repeat	304..339	CDD:293788	21/34 (62%)
		ARM	307..442	CDD:237987	73/144 (51%)
		armadillo repeat	347..392	CDD:293788	19/54 (35%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	79/126 (63%)
		armadillo repeat	562..596	CDD:293788	28/33 (85%)
		armadillo repeat	601..641	CDD:293788	23/39 (59%)
Pkp4	XP_036016888.1	Atrophin-1	72..>382	CDD:397323
		armadillo repeat	545..570	CDD:293788	13/24 (54%)
		Arm	574..613	CDD:395413	20/38 (53%)
		armadillo repeat	578..614	CDD:293788	20/35 (57%)
		ARM	618..659	CDD:214547	25/40 (63%)
		armadillo repeat	622..657	CDD:293788	21/34 (62%)
		armadillo repeat	664..715	CDD:293788	20/55 (36%)
		armadillo repeat	723..764	CDD:293788	21/40 (53%)
		Arm	829..870	CDD:395413	24/47 (51%)
		armadillo repeat	840..870	CDD:293788	17/29 (59%)
		PLN03200	863..>984	CDD:215629	75/122 (61%)
		ARM	880..915	CDD:214547	29/34 (85%)
		armadillo repeat	882..914	CDD:293788	26/31 (84%)
		armadillo repeat	921..962	CDD:293788	23/42 (55%)
		ARM	964..1008	CDD:214547	21/43 (49%)
		armadillo repeat	968..1003	CDD:293788	16/34 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6347
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1889
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43460
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890