DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ARMC3

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_775104.2	Gene:	ARMC3 / 219681	HGNCID:	30964	Length:	872	Species:	Homo sapiens

Alignment Length:	722	Identity:	141/722 - (19%)
Similarity:	247/722 - (34%)	Gaps:	202/722 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 IEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLV 273
            :|....|:...:.......:.|:..|::|...|.|.|...:.......:.||.....||.:.||.
Human     9 VEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLT 73

  Fly   274 RLLSYDSPEIHKNACGALRNLSYG--RQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVL 336
            :||:::...:.:||     .:.:|  ..|::.|:.::....:.:::..|...:|..:.|..:..|
Human    74 KLLTHEDKIVRRNA-----TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCL 133

  Fly   337 WNMSSCEDLKRSIID----EALVAVVCSV---IKPHS-------GWDAVCCGE------------ 375
            .|||:....|..|.:    |.|:.::.|.   :|.:|       ..|..|..:
Human   134 ANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILD 198

  Fly   376 ------TCFSTVFRNASGVLRNVSSAGEHARGCLRN---CEHLVECLLYVVRTSIEKNNIGNKTV 431
                  .....:.....||:.|    .:.:|..||:   .:||::.|        |...:.:..:
Human   199 LLKSEYPVIQLLALKTLGVIAN----DKESRTMLRDNQGLDHLIKIL--------ETKELNDLHI 251

  Fly   432 E------NCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKG------------ENLGCFG 478
            |      ||   |.::....|........|.........||...|.            ||...|.
Human   252 EALAVIANC---LEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFH 313

  Fly   479 TNKKKK--------EANNSDALNEYNISA--DYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQS 533
            ..:.:|        |.:.:.......|||  :.|.|...:|  |:|..||         :.||:|
Human   314 EQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFN--NQGIPQL---------IQLLKS 367

  Fly   534 CSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKE-KGLPILVELLRMEVDRVVCAVATALRNLA 597
             .|.|..||||.|:.||:.|  .|:   .|....| .|:..|:.||..:.|..:...||.|.|:|
Human   368 -DNEEVREAAALALANLTTC--NPA---NANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMA 426

  Fly   598 IDQ------RNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLL 656
            :.:      :|.::     |..::..|.|.|..    .......||.||..:|     |....|.
Human   427 MQEPLRLNIQNHDI-----MHAIISPLRSANTV----VQSKAALAVTATACDV-----EARTELR 477

  Fly   657 DSGGIDRLMNITKRK----EKYTS----------------CVL-----------------KFASQ 684
            :|||::.|:.:.:.|    .|:.|                |.|                 || |:
Human   478 NSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKF-SE 541

  Fly   685 VLYTMWQHNELRDVYKKNGW-KEQDFVSKHF---------------------------------- 714
            ..|....:|.|...|.:.|: ...:.::..|
Human   542 AAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRAVLLINS 606

  Fly   715 TAHNTPPSSPNNVNNT-LNRPMASQGRTRYEDRTIQRGTSTLYSAN-----DSSGAVMSNESAML 773
            .::.:||||..:.::. ..|.::|....|...:...:..|..:||.     :......|..:.:|
Human   607 KSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVL 671

  Fly   774 SEMVRKQ 780
            |:...|:
Human   672 SKSATKE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	25/115 (22%)
		armadillo repeat	227..252	CDD:293788	6/24 (25%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	5/34 (15%)
		ARM	307..442	CDD:237987	30/175 (17%)
		armadillo repeat	347..392	CDD:293788	10/76 (13%)
		armadillo repeat	515..556	CDD:293788	15/40 (38%)
		ARM	516..643	CDD:237987	37/133 (28%)
		armadillo repeat	562..596	CDD:293788	10/34 (29%)
		armadillo repeat	601..641	CDD:293788	8/39 (21%)
ARMC3	NP_775104.2	ARM 1	15..54		7/38 (18%)
		armadillo repeat	21..52	CDD:293788	6/30 (20%)
		HEAT_2	32..108	CDD:290374	18/80 (23%)
		ARM 2	57..96		11/43 (26%)
		armadillo repeat	60..96	CDD:293788	10/40 (25%)
		ARM	63..179	CDD:237987	25/120 (21%)
		ARM 3	98..138		7/39 (18%)
		HEAT repeat	106..137	CDD:293787	5/30 (17%)
		ARM 4	140..179		7/38 (18%)
		armadillo repeat	143..177	CDD:293788	7/33 (21%)
		ARM	145..259	CDD:237987	19/125 (15%)
		HEAT_2	152..258	CDD:290374	18/117 (15%)
		ARM 5	181..220		3/38 (8%)
		armadillo repeat	184..220	CDD:293788	2/35 (6%)
		ARM 6	222..262		10/50 (20%)
		armadillo repeat	225..259	CDD:293788	8/41 (20%)
		ARM 7	264..304		5/39 (13%)
		ARM 8	306..345		8/38 (21%)
		ARM	321..426	CDD:237987	36/121 (30%)
		ARM 9	346..385		19/50 (38%)
		armadillo repeat	358..383	CDD:293788	12/34 (35%)
		ARM 10	388..427		12/41 (29%)
		armadillo repeat	391..436	CDD:293788	12/44 (27%)
		ARM 11	429..468		9/47 (19%)
		ARM	435..529	CDD:237987	21/107 (20%)
		armadillo repeat	435..465	CDD:293788	7/38 (18%)
		ARM 12	470..509		10/43 (23%)
		armadillo repeat	473..503	CDD:293788	8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..693		14/69 (20%)
		EDR1	<720..858	CDD:291079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940