DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and hmp-2

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001252425.1	Gene:	hmp-2 / 173338	WormBaseID:	WBGene00001979	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	147/811 - (18%)
Similarity:	262/811 - (32%)	Gaps:	310/811 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRP 160
            |.||:.......|...:::.|...|..|.|....:.:.|   ||.|..|   |:|:||......|
Worm    23 LPTTMLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPP---TSAAEAT---NSTTSIVEMMQMP 81

  Fly   161 FNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMRWRDP 225
            ..                       :|.|..|..:.            .||| ||:...
Worm    82 TQ-----------------------QLKQSVMDLLT------------YEGS-NDMSGL------ 104

  Fly   226 NLSEVISFLSNPSSAIKANAAAYLQHLCYM---DDPNKQRT-----RSLGGIPPLVRLLSYDSPE 282
            :|.:::..:.:...::.|.|.    |..||   :|||....     ||.  :..|:......:..
Worm   105 SLPDLVKLMCDHDESVVARAV----HRAYMLSREDPNFFNAPGFDHRSF--VEALMAASKSSNVN 163

  Fly   283 IHKNACGALRNLSYGRQNDENKRG---IKNAGGIAALVHLLCRSQETEVKELVT---GVLWNMSS 341
            :.:||.|||.::|      |.:.|   |..:||:|.::.:|..|.|:.|...||   .:|.::|.
Worm   164 VRRNAIGALSHMS------EQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSD 222

  Fly   342 CEDLKRS-----------------------------IIDEA--------LVA--VVCSVIKPHSG 367
            .....|:                             :||:|        |:.  ::.|:::.:|.
Worm   223 SRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSD 287

  Fly   368 -----WDAVCC------------------------GETCFSTVFRNASGVL---RNVSSAGEHAR 400
                 :..|.|                        .|.|.:...|:.:.:|   ||:|.:..:.
Worm   288 HRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNE- 351

  Fly   401 GCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVI 465
               .|...|:..||.::|       :.|..:..|.|  ..||
Worm   352 ---ENLTQLIIKLLEIIR-------VANDGMTACAC--GTLS----------------------- 381

  Fly   466 PSSSKGENLGCFGTNKKKKEANNS--DALNEYNISADYSKSSVTYNKLNKGYEQLWQP------- 521
                   ||.|..|..|:...::.  |||             ||..:.....|::.:|
Worm   382 -------NLTCNNTRNKQTVCSHGGIDAL-------------VTAIRRLPEVEEVTEPALCALRH 426

  Fly   522 ------------------EVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDI--RATVR 566
                              :.....|..|::...| .::||.|.|:| ||......|::  ..|..
Worm   427 CTARHSLAEEAQSELRFCQAFPVILDQLETLRTP-VIKAALGVIRN-SALLQTNLIELTQEQTAN 489

  Fly   567 KEKGLPILVELLRMEVDR----------------VVCAVATALRNLAIDQRNKELIGKYAMRDLV 615
            ....:.:.:::||..:..                |:....:||..||    |...:......|:.
Worm   490 GHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLA----NHPAVAAACCDDIG 550

  Fly   616 QKLPSGN-------------VQHDQ--NTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLM 665
            |   .||             :.|.:  :..|:.:...:..:...:.|.|:.:|: ::|.|:..|:
Worm   551 Q---VGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGARA-VESTGVSALL 611

  Fly   666 NITKRKEKYTSCVLKFASQVL-------------------YTM------WQHNELRDVYKKNGWK 705
             :..|..:|.| |:.:|:.||                   |.|      ||.:.|
Worm   612 -MESRGSQYKS-VVTYANGVLSNLKRGDSAAIMNMSNSYDYEMSGSAADWQRDGL---------- 664

  Fly   706 EQDFVSKHFTAHNTPPSSPNN--VNNTLNRP 734
            |::..::.:..::...|...|  :||:..||
Worm   665 ERELFAEMYPTNDGGHSESINMALNNSQMRP 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	31/127 (24%)
		armadillo repeat	227..252	CDD:293788	3/24 (13%)
		armadillo repeat	260..296	CDD:293788	8/40 (20%)
		armadillo repeat	304..339	CDD:293788	12/40 (30%)
		ARM	307..442	CDD:237987	36/208 (17%)
		armadillo repeat	347..392	CDD:293788	14/115 (12%)
		armadillo repeat	515..556	CDD:293788	12/65 (18%)
		ARM	516..643	CDD:237987	28/184 (15%)
		armadillo repeat	562..596	CDD:293788	6/49 (12%)
		armadillo repeat	601..641	CDD:293788	7/54 (13%)
hmp-2	NP_001252425.1	ARM	106..216	CDD:237987	30/121 (25%)
		HEAT_2	106..>185	CDD:290374	20/90 (22%)
		HEAT repeat	106..137	CDD:293787	7/34 (21%)
		HEAT repeat	149..177	CDD:293787	7/35 (20%)
		ARM	183..303	CDD:237987	21/119 (18%)
		armadillo repeat	185..216	CDD:293788	10/30 (33%)
		armadillo repeat	224..260	CDD:293788	1/35 (3%)
		armadillo repeat	275..302	CDD:293788	4/26 (15%)
		Arm	305..346	CDD:278915	6/40 (15%)
		armadillo repeat	309..349	CDD:293788	7/39 (18%)
		ARM	357..473	CDD:237987	29/169 (17%)
		armadillo repeat	358..383	CDD:293788	8/63 (13%)
		armadillo repeat	391..429	CDD:293788	8/50 (16%)
		armadillo repeat	438..471	CDD:293788	7/33 (21%)
		ARM	518..633	CDD:237987	25/124 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030