DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and Ctnnd1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_006498688.1	Gene:	Ctnnd1 / 12388	MGIID:	105100	Length:	967	Species:	Mus musculus

Alignment Length:	789	Identity:	278/789 - (35%)
Similarity:	383/789 - (48%)	Gaps:	125/789 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PTGVGAITKVAPHCSQNKIET-------NSTDNSIPDIENHPLATTVR---YVQAG---QYED-- 110
            |.|...:...|...|.|.|:|       |......|.:.....||..|   |...|   .|||
Mouse   157 PMGPDGLPVDASAVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYGRHYEDGY 221

  Fly   111 ---TSEYGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQ------NTTSSIKPFSGRPFNDNIN 166
               :..||.......|:..| ..::..|...|..:..|.|      .::..:..|...|:
Mouse   222 PGGSDNYGSLSRVTRIEERY-RPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPY----- 280

  Fly   167 GAEAVADSQCRTFKSSAEFKLPQFAMSSINTV---------PQRLEEKDDYI------------- 209
            |.|   |.|    :|.....|....||...|.         .:||...:|.|
Mouse   281 GLE---DDQ----RSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPPDQYYWAP 338

  Fly   210 -----EGSENDICSTMR-------WRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQR 262
                 .||...:.|..:       ||.|.|.|||:.|.....|:|:|||||||||||.:|..|..
Mouse   339 LAQHERGSLASLDSLRKGMPPPSNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTD 403

  Fly   263 TRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETE 327
            .|.|.|||.||.||.:...|:|..|||||:|:|:||..| ||..|||..|:.|||.||.::::.:
Mouse   404 VRKLKGIPILVGLLDHPKKEVHLGACGALKNISFGRDQD-NKIAIKNCDGVPALVRLLRKARDMD 467

  Fly   328 VKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETC------FSTVFRNAS 386
            :.|::||.|||:||.:.:|..|:|.||.|:...||.|||||:.. ..|.|      :.:|..|.:
Mouse   468 LTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWERE-PNEDCKPRHIEWESVLTNTA 531

  Fly   387 GVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDP 451
            |.||||||....||..||.|:.||:.|:::|:..|.:.:..:|.||||||:||||||:... :.|
Mouse   532 GCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHR-EIP 595

  Fly   452 NYDKHPFITPERVIPSSSKGENLGCFGTNKKKKE------ANNSDALNEYNISADYSKSSVTYNK 510
            ..:::....|  .:.:|:......|||..|.|.|      ....|..|:   :.|:.|.:    .
Mouse   596 QAERYQEALP--TVANSTGPHAASCFGAKKGKDEWFSRGKKPTEDPAND---TVDFPKRT----S 651

  Fly   511 LNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILV 575
            ..:|||.|:|||||:.|:|||:....|..|||:|||||||.|..|.....||:.:|:||.|..:.
Mouse   652 PARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIA 716

  Fly   576 ELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLAT 640
            |||..|.:|||.|.:.||||||:|.||||||||:|:.:||:.||.|......|.|:||:.::|.|
Mouse   717 ELLTSEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVVSILNT 781

  Fly   641 INEVIKKNPEFSRSLLDSGGIDRLMNITK---RKEKYTSCVLKFASQVLYTMWQHNELRDVYKKN 702
            |||||.:|.|.::.|.::.||::|:.|.|   |.||    .::.|:.||.|:|.:.|||...:|.
Mouse   782 INEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEK----EVRAAALVLQTIWGYKELRKPLEKE 842

  Fly   703 GWKEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMASQGRTRYEDRTIQRGTSTLYSANDSSGAVMS 767
            |||:.||                .||  ||....||....|:|.|:     .|...|..|.....
Mouse   843 GWKKSDF----------------QVN--LNNASRSQSSHSYDDSTL-----PLIDRNQKSDKKPD 884

  Fly   768 NESAMLSEM 776
            .|...:|.|
Mouse   885 REEIPMSNM 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	58/113 (51%)
		armadillo repeat	227..252	CDD:293788	14/24 (58%)
		armadillo repeat	260..296	CDD:293788	18/35 (51%)
		armadillo repeat	304..339	CDD:293788	15/34 (44%)
		ARM	307..442	CDD:237987	61/140 (44%)
		armadillo repeat	347..392	CDD:293788	19/50 (38%)
		armadillo repeat	515..556	CDD:293788	24/40 (60%)
		ARM	516..643	CDD:237987	66/126 (52%)
		armadillo repeat	562..596	CDD:293788	16/33 (48%)
		armadillo repeat	601..641	CDD:293788	19/39 (49%)
Ctnnd1	XP_006498688.1	armadillo repeat	368..393	CDD:293788	14/24 (58%)
		ARM	397..437	CDD:214547	19/39 (49%)
		armadillo repeat	401..437	CDD:293788	18/35 (51%)
		Arm	440..481	CDD:395413	18/41 (44%)
		armadillo repeat	444..479	CDD:293788	15/34 (44%)
		armadillo repeat	486..537	CDD:293788	20/51 (39%)
		Syo1_like	632..>740	CDD:240521	50/114 (44%)
		armadillo repeat	656..693	CDD:293788	23/36 (64%)
		ARM	703..738	CDD:214547	17/34 (50%)
		armadillo repeat	703..737	CDD:293788	16/33 (48%)
		armadillo repeat	793..829	CDD:293788	12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839538
Domainoid	1	1.000	109	1.000	Domainoid score	I6347
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1889
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900