DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and PKP3

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001289958.1	Gene:	PKP3 / 11187	HGNCID:	9025	Length:	812	Species:	Homo sapiens

Alignment Length:	747	Identity:	200/747 - (26%)
Similarity:	336/747 - (44%)	Gaps:	176/747 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYED 110
            |.||||..     .:||                          |.:...|    |.:.:.|....
Human   158 FGAAGYGG-----AQPT--------------------------PPMPTRP----VSFHERGGVGS 187

  Fly   111 TSEYGVAGLTC------GIDSEYT--AEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDNING 167
            .::|....|..      |:|..|:  :|.:.| ..||.......:...||....:|     .::.
Human   188 RADYDTLSLRSLRLGPGGLDDRYSLVSEQLEP-AATSTYRAFAYERQASSSSSRAG-----GLDW 246

  Fly   168 AEAVADSQCRTFKSSAEFKLPQFAMS----------------------SINTVP----------- 199
            .||...|..||.::.|...|.:|..|                      |:.::.
Human   247 PEATEVSPSRTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPD 311

  Fly   200 -------------QRLEEKDDYIEGSENDICSTMRW---RDPNLSEVISFLSNPSSAIKANAAAY 248
                         |||....|.|     |:.|.:::   .||||..:              .|||
Human   312 VHGFNSYGSHRTLQRLSSGFDDI-----DLPSAVKYLMASDPNLQVL--------------GAAY 357

  Fly   249 LQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGI 313
            :||.||.|...|::.|||..:|.||:|.::.:.|:.::|.||:|||.|  .|.:||..:....||
Human   358 IQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIY--DNADNKLALVEENGI 420

  Fly   314 AALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCG---- 374
            ..|:..| |.|:.|:::.|||:|||:||.:.||..:..:.|..:...|:.|.||     .|
Human   421 FELLRTL-REQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSG-----AGGPPL 479

  Fly   375 ---ETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVC 436
               ....:.:|.||:|.|||:|||.:..|..:|.|..||:.|:..:..:::.....:|:|||.||
Human   480 IQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVENAVC 544

  Fly   437 ILRNLSYRCQEVDDPNYDKHPFITPERV-------IPSSSKGENLGCFGTNKKKKEANNSDALNE 494
            :|||||||.       ||:.|....:|:       :..:..||.:|||....::        |.|
Human   545 VLRNLSYRL-------YDEMPPSALQRLEGRGRRDLAGAPPGEVVGCFTPQSRR--------LRE 594

  Fly   495 YNISADYSKSSVTYNKLN---KGYEQLWQPEVVQYYLSLLQSCS-NPETLEAAAGAIQNLSA--C 553
            ..::||    ::|:.:::   ||.|.||.|::|..|..|||.|. |..|.||||||:||::|  .
Human   595 LPLAAD----ALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDR 655

  Fly   554 YWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKL 618
            .|...:. |..:.:|:.|..|::.:|......:.::...:|||:.:.|||:.:....:..|::||
Human   656 RWAGVLS-RLALEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKL 719

  Fly   619 PSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-----EKYTSCV 678
            | |:| .:::...:.:..::|.:|.::..:|..:|.||...|:.:|:.|.|::     ||.:
Human   720 P-GSV-GEKSPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSS--- 779

  Fly   679 LKFASQVLYTMWQHNELRDVYKKNGWKEQDFV 710
             :.||.:|..:||:|:|...::..|::::||:
Human   780 -RAASSLLANLWQYNKLHRDFRAKGYRKEDFL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	41/113 (36%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	15/35 (43%)
		armadillo repeat	304..339	CDD:293788	13/34 (38%)
		ARM	307..442	CDD:237987	48/141 (34%)
		armadillo repeat	347..392	CDD:293788	12/51 (24%)
		armadillo repeat	515..556	CDD:293788	21/43 (49%)
		ARM	516..643	CDD:237987	40/129 (31%)
		armadillo repeat	562..596	CDD:293788	6/33 (18%)
		armadillo repeat	601..641	CDD:293788	10/39 (26%)
PKP3	NP_001289958.1	ARM	336..447	CDD:237987	45/127 (35%)
		armadillo repeat	336..361	CDD:293788	9/38 (24%)
		armadillo repeat	369..405	CDD:293788	15/35 (43%)
		armadillo repeat	411..445	CDD:293788	13/34 (38%)
		ARM	412..550	CDD:237987	48/143 (34%)
		armadillo repeat	464..500	CDD:293788	11/40 (28%)
		armadillo repeat	508..549	CDD:293788	14/40 (35%)
		ARM	639..744	CDD:237987	30/107 (28%)
		armadillo repeat	663..697	CDD:293788	6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810