DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and pkp3

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_004913456.1	Gene:	pkp3 / 100498319	XenbaseID:	XB-GENE-489317	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	850	Identity:	214/850 - (25%)
Similarity:	356/850 - (41%)	Gaps:	226/850 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DLSLTHEPANMQSQFGS------------FQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCS 75
            |.||....|.:|.|..:            ..|.:.:|.:.|....|..|: .|.|:    |.:.|
Frog    34 DESLVQRNARVQEQVRAKLMQKTHTAPRVSSNSNSYSVSSYGDVFLPRTQ-YGTGS----ASYSS 93

  Fly    76 QNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVV------- 133
            ::::           :.:.|..:.||         ||.|...|   |:.|.|::.:.|
Frog    94 RSQV-----------LSSEPRMSAVR---------TSGYSTGG---GMRSGYSSRSAVDVGGTQR 135

  Fly   134 --------PYCYT--------------------------------------SDANYTGIQNTTSS 152
                    .|..|                                      |.|:..|.|.:|||
Frog   136 ISVASQQRSYATTRPTSFHEKVYPARRDYDTMSLRSLRIGDGEERYNPGTASQASVYGRQISTSS 200

  Fly   153 IKPFSGRPFNDNI-------NGAEAVADSQCRTFKSSAEFKLPQFAMSS---INTVP-------- 199
            ..|...|..:.||       :..|....:|.||.::.|...|.:|..::   :.:||
Frog   201 AGPMLQRSLSGNIGQDVGGTSWVERAEVAQTRTIRAPAMRTLQRFQSTNRTRVGSVPYGTINTGS 265

  Fly   200 -------------QRLEEKD-------------------------------------DYIEGSEN 214
                         |::::..                                     |..:|:::
Frog   266 QQQMQQMQQIQQMQQMQQSSGGIGSSYVTNMIEHNSRAPSVRSLAESGNQVQEIRGIDMFDGNKS 330

  Fly   215 DICS---TMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLL 276
            .:..   |..:.|.::...:..|..|...::...|||:||.||.|:..|::.|||..||.||:|.
Frog   331 LMSQHSFTSGFDDMDMPMAVKNLMAPDPNLQVLGAAYIQHRCYSDNEAKKQARSLQAIPKLVKLF 395

  Fly   277 SYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSS 341
            :.|:.|:.::|.||:|||.|  .|.|||..:....||..|:..| ...:.|:::.|||:|||:||
Frog   396 NCDNQEVQRHATGAMRNLIY--DNPENKIALVEENGIYELLTAL-EEHDDELRKNVTGILWNLSS 457

  Fly   342 CEDLKRSIIDEALVAVVCSVIKPHSG--WDAVCCGETCFSTVFRNASGVLRNVSSAGEHARGCLR 404
            .::||..:..:.|..:...|:.|.||  ..||.......:.:|.||:|.|||:|||....|..:|
Frog   458 SDNLKARLARDTLSPLTQKVLSPLSGTAGSAVIQQNVSEAEIFYNATGFLRNLSSASPETRQKMR 522

  Fly   405 NCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSS- 468
            .|..|::.|:.....:::.....:|:|||.||:|||||||.       ||:.|        ||:
Frog   523 ECSGLLDALVSYTNNALQSGKSEDKSVENAVCVLRNLSYRL-------YDEMP--------PSNL 572

  Fly   469 -----------SKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLN---KGYEQLW 519
                       :.|:.:|||....:|        |.|....||.:    |:.:::   ||.|.||
Frog   573 QRLEGGQRGRITAGDTVGCFTPQSRK--------LKEQQQGADIA----TFTEISRDPKGMELLW 625

  Fly   520 QPEVVQYYLSLLQSCS-NPETLEAAAGAIQNLSA--CYWQPSIDIRATVRKEKGLPILVELLRME 581
            .|::|..|..|||.|. |..|.||||||:||::|  ..| .|:..:..:.:|:.|..:::.||..
Frog   626 HPQIVNLYNRLLQHCELNKYTTEAAAGALQNITAGDRRW-ASVLSQVALEQERILNPVLDRLRTA 689

  Fly   582 VDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIK 646
            ....:.::...:|||:...:||:.:....:..|::||||.:  .::....|.:..::|.:|.:..
Frog   690 DHNQLRSLTGLIRNLSRHAKNKDEMSTKLVSHLLEKLPSDS--SEKCPPADVLVNIIAILNNLTV 752

  Fly   647 KNPEFSRSLLDSGGIDRLMNITKRK-----EKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKE 706
            ..|..:|.::...|:.:||.|.|.|     ||    ..:.|..:|..|||:::|...||..|:::
Frog   753 AGPLAARDIVYFNGLIKLMYIKKMKDSADGEK----AARAACSLLTNMWQYSKLHREYKSKGYRK 813

  Fly   707 QDFVS 711
            .||:|
Frog   814 DDFLS 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	43/113 (38%)
		armadillo repeat	227..252	CDD:293788	6/24 (25%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	11/34 (32%)
		ARM	307..442	CDD:237987	46/136 (34%)
		armadillo repeat	347..392	CDD:293788	13/46 (28%)
		armadillo repeat	515..556	CDD:293788	21/43 (49%)
		ARM	516..643	CDD:237987	39/129 (30%)
		armadillo repeat	562..596	CDD:293788	5/33 (15%)
		armadillo repeat	601..641	CDD:293788	9/39 (23%)
pkp3	XP_004913456.1	Keratin_2_head	83..>138	CDD:374433	15/82 (18%)
		armadillo repeat	346..371	CDD:293788	6/24 (25%)
		Syo1_like	350..>559	CDD:240521	77/211 (36%)
		ARM	375..415	CDD:214547	18/39 (46%)
		armadillo repeat	379..415	CDD:293788	17/35 (49%)
		ARM	417..457	CDD:214547	15/40 (38%)
		armadillo repeat	421..455	CDD:293788	11/34 (32%)
		armadillo repeat	670..704	CDD:293788	5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110