DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and jupb

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_002665522.2	Gene:	jupb / 100330886	ZFINID:	ZDB-GENE-110407-10	Length:	722	Species:	Danio rerio

Alignment Length:	753	Identity:	157/753 - (20%)
Similarity:	257/753 - (34%)	Gaps:	222/753 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 STDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLT-------------CGIDSEYTAEAVVP 134
            |...|..|:|.....|..:.|:|..:.:|...|...||             ....|:....|:|.
Zfish    47 SAGESSADMEAQFSLTRAQRVRAAMFPETLVEGETVLTPQSNPDQPTNVQRLAEPSQLLKTAIVH 111

  Fly   135 YC-YTSDANYTGIQNTTSSIKPFSGRPFNDN---INGAEAVADSQCRTFKSSAEFKLPQFAMSSI 195
            .. |..||     :..|.::...:....:|:   :|.|..:.:...|  |.::...|.| :...:
Zfish   112 LINYQDDA-----ELATRAVPELTKLLADDDQVVVNKAALIVNQLTR--KEASRRVLMQ-SPQMV 168

  Fly   196 NTVPQRLEEKDDYIEGSENDIC--------STMR------WRDPNLSEVISFLSNPSSAIKANAA 246
            :.|.:.::...|.    |...|        |..|      ::...:..::..||:|..::...|.
Zfish   169 SAVVRAMQNTGDL----ETARCAASVLHSLSHQREGLLAIFKSGGIPALVRMLSSPMESVLFYAI 229

  Fly   247 AYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDE--------- 302
            ..|.:|....:..|...|...|:..:|.||...:|:........|:.||||.|..:
Zfish   230 TTLHNLLLHQEGAKMAVRLADGLQRMVPLLKKTNPKFLAITTDCLQLLSYGNQESKLIILANGGP 294

  Fly   303 -------------------------------NKRGIKNAGGIAAL-VHLLCRSQETEVKELVTGV 335
                                           ||..|.::||:.|| .||...||     .|....
Zfish   295 ECLVFIMRNYNYEKLLWTTSRVLKVLSVCPSNKPAIVDSGGMQALGQHLTGSSQ-----RLTQNC 354

  Fly   336 LWNMSSCED--LKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCFSTVFRNASGVLRNVSSAGEH 398
            ||.:.:..|  .|:..:|..|..:|..:     |.|.|.. .||       |:|:|.|::.  .:
Zfish   355 LWTLRNLSDAATKQEGLDGLLQILVSQL-----GSDDVNM-LTC-------ATGILSNLTC--NN 404

  Fly   399 ARG-CLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPE 462
            ||. .|......||.|::.|..:.||.::    .|..||.||:|:.|           ||
Zfish   405 ARNKALVTQSGGVEALIHAVLRAGEKEDV----AEPAVCALRHLTSR-----------HP----- 449

  Fly   463 RVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYY 527
                               ..:.|.|:..|: |.|.|        ..||      |.||   .|:
Zfish   450 -------------------DAELAQNAVRLH-YGIPA--------ITKL------LGQP---HYW 477

  Fly   528 LSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELL-------------- 578
                      ..::|..|.|:||:.|   |:  .:|.:|:...:|.||.||
Zfish   478 ----------PVVKATVGLIRNLALC---PA--NQAPLRESGAIPRLVNLLLKAHQETQRHGSGA 527

  Fly   579 --------RMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDDTIT 635
                    |||  .:|.....||..||.|..|:..|.......|..:|....|::.:..|    .
Zfish   528 QQTYQDGVRME--EIVEGCTGALHILARDPMNRGEIASMQTIPLFVQLLYSYVENIKRVS----A 586

  Fly   636 AVLATINEVIKKNPEFSRSLLDSGGIDR-LMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVY 699
            .||..:  .:.|.   |..::|:.|... ||.:.....:   .:..:|:.||:.: ..::..|..
Zfish   587 GVLCEL--ALDKQ---SAEMIDAEGASAPLMELLHSPNE---GIATYAAAVLFRI-SEDKSSDYR 642

  Fly   700 KKNGWKEQDFVSKH-----FTAHNTPPSSPNNVNNTLN 732
            |:...:....:.||     ..||...|..|..:.:.|:
Zfish   643 KRVSVELTHSLFKHDPAAWDMAHAAMPLDPGYIPDDLD 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	33/154 (21%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	9/35 (26%)
		armadillo repeat	304..339	CDD:293788	13/35 (37%)
		ARM	307..442	CDD:237987	40/138 (29%)
		armadillo repeat	347..392	CDD:293788	11/44 (25%)
		armadillo repeat	515..556	CDD:293788	10/40 (25%)
		ARM	516..643	CDD:237987	35/148 (24%)
		armadillo repeat	562..596	CDD:293788	13/55 (24%)
		armadillo repeat	601..641	CDD:293788	8/39 (21%)
jupb	XP_002665522.2	armadillo repeat	126..151	CDD:293788	3/24 (13%)
		armadillo repeat	168..194	CDD:293788	4/29 (14%)
		PLN03200	<186..>457	CDD:331927	69/329 (21%)
		armadillo repeat	203..235	CDD:293788	5/31 (16%)
		ARM	203..235	CDD:214547	5/31 (16%)
		armadillo repeat	243..279	CDD:293788	9/35 (26%)
		armadillo repeat	285..320	CDD:293788	0/34 (0%)
		ARM	323..363	CDD:214547	14/44 (32%)
		armadillo repeat	327..362	CDD:293788	13/39 (33%)
		PLN03200	<374..>639	CDD:331927	81/366 (22%)
		armadillo repeat	375..400	CDD:293788	10/37 (27%)
		armadillo repeat	408..446	CDD:293788	13/41 (32%)
		armadillo repeat	455..490	CDD:293788	14/62 (23%)
		armadillo repeat	497..553	CDD:293788	14/57 (25%)
		armadillo repeat	558..592	CDD:293788	7/37 (19%)
		armadillo repeat	600..633	CDD:293788	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940