DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and pkp3b

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_002662884.1	Gene:	pkp3b / 100330353	ZFINID:	ZDB-GENE-130530-870	Length:	791	Species:	Danio rerio

Alignment Length:	729	Identity:	198/729 - (27%)
Similarity:	330/729 - (45%)	Gaps:	98/729 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SQF-GSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSIPDIENHPLAT 98
            ||: |.|.:.............|.:..|..||     .|:...:....:|:.|.:...|:..|:.
Zfish   102 SQYAGDFSSRSAVETGTRHRISLGVPMPAVVG-----RPYTYHDDAHLSSSYNQMQTSESRTLSR 161

  Fly    99 TVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFN- 162
            |.:.|.|          :||||...........:..|..:...|....|.|.|......|  ||
Zfish   162 TEQEVAA----------MAGLTLQRQPSPVGNWMPNYGQSPSPNTAHRQRTLSGTLAREG--FNT 214

  Fly   163 ---------------------DNINGAEAVADSQCRTFKSSAEFKLPQF---------------- 190
                                 ..||..:.......|...||.:::....
Zfish   215 GWREAELANQYAFKGPSHRTISRINNRQVQQQQHQRLSGSSMQWQQMSTGGNSLMGAGHYQGTIK 279

  Fly   191 ---AMSSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHL 252
               ::.|:.:|.:.::..|...:|:.:.:...   .:.:::..:|:||:...:::...|||:||.
Zfish   280 RAGSVHSMKSVGRGVDVYDGLADGTADGLGGI---HNLDMTTAVSYLSSTDVSMQMLGAAYVQHQ 341

  Fly   253 CYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALV 317
            ||..:..|...|||.||..||:|.|.::.|:.:.|.||.|||.|  :|.:||..:..||||:.|:
Zfish   342 CYHSNEAKTMVRSLKGISALVQLFSSENQEVQRYATGATRNLIY--ENMDNKTALIEAGGISKLI 404

  Fly   318 HLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHS-GWDA-VCCGETCFST 380
            ..| |..:.|:::.:||:|||:||.:.||..:..|:|..:...|:.|.| |.|| |.......:.
Zfish   405 GAL-REPDDELRKNITGILWNLSSKDSLKERLARESLAELTERVLVPLSGGGDAGVIQQSASEAD 468

  Fly   381 VFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRC 445
            :|.|.:|.|||:||..|..|..:|....||:.|:..::.|:::....||.||||||:||||||:.
Zfish   469 IFFNTTGCLRNLSSVNERTRQQMRETRGLVDSLVGYIQNSLQEGKGENKGVENCVCVLRNLSYQL 533

  Fly   446 QEVDDPNYDKHPFITPERV-----IPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSS 505
                   |.:.|.....|:     ...:...:.:|||....||.:..|.|......::
Zfish   534 -------YSEIPSSVQMRLEGPTRAQDTRHSDAIGCFTPQSKKAKDRNQDLTTFTEVA------- 584

  Fly   506 VTYNKLNKGYEQLWQPEVVQYYLSLLQSC-SNPETLEAAAGAIQNLSA--CYWQPSIDIRATVRK 567
                ::.||.|.||.|::|..|..:|||| :|..|.||||||:||::|  ..| .|:..|..:.:
Zfish   585 ----RVPKGAEWLWHPQIVSLYNQILQSCEANTATREAAAGALQNITAGDSRW-ASVLSRVALEQ 644

  Fly   568 EKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTSDD 632
            |:.||::::|||...|..:.::...||||:...:||..:....:..||.||||..  |.:..|.:
Zfish   645 ERMLPVILDLLRSPTDAELRSLTGLLRNLSRHCKNKADMATKVVNVLVNKLPSDG--HQKEPSSE 707

  Fly   633 TITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCV--LKFASQVLYTMWQHNEL 695
            .:..:...:|.::..:...:|.:....|:.:|::|....:.....:  .:.||.||..|:|:|:|
Zfish   708 VVVNICGVLNNLVTGSSLAARDITYFDGLPKLVSIKSSHDNSPGKLKAARAASTVLSNMFQYNKL 772

  Fly   696 RDVYKKNGWKEQDF 709
            ...||:.|:..:||
Zfish   773 HRDYKQKGFARRDF 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	44/113 (39%)
		armadillo repeat	227..252	CDD:293788	7/24 (29%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	13/34 (38%)
		ARM	307..442	CDD:237987	52/136 (38%)
		armadillo repeat	347..392	CDD:293788	14/46 (30%)
		armadillo repeat	515..556	CDD:293788	21/43 (49%)
		ARM	516..643	CDD:237987	45/129 (35%)
		armadillo repeat	562..596	CDD:293788	10/33 (30%)
		armadillo repeat	601..641	CDD:293788	10/39 (26%)
pkp3b	XP_002662884.1	ARM	320..427	CDD:237987	44/109 (40%)
		armadillo repeat	349..385	CDD:293788	17/35 (49%)
		armadillo repeat	391..425	CDD:293788	13/34 (38%)
		armadillo repeat	446..480	CDD:293788	12/33 (36%)
		ARM	641..768	CDD:237987	31/128 (24%)
		armadillo repeat	641..673	CDD:293788	9/31 (29%)
		armadillo repeat	680..721	CDD:293788	10/42 (24%)
		armadillo repeat	727..766	CDD:293788	8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.810