DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ctnnd1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001119545.1	Gene:	ctnnd1 / 100101665	XenbaseID:	XB-GENE-919827	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	811	Identity:	254/811 - (31%)
Similarity:	374/811 - (46%)	Gaps:	173/811 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IENHPLATTVRYVQAGQYEDTSEYGVAGLTCGID-----SEYTAEAVVPYCYTSDANY---TGIQ 147
            :|.|.:....|||    .:|.|.|    .:|.::     :|...:.:|.|..|.|..|   .|..
Frog    75 MEAHSVHADERYV----IDDDSSY----KSCTLNDETRCNEIPVQTIVGYSQTLDRPYREPAGGG 131

  Fly   148 NTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDY---- 208
            .|.:::      |.|.:..|..  .||.......|     |....||::...||....|.|
Frog   132 GTYTTV------PRNYHFRGPG--VDSTMPVISQS-----PHPGYSSLSRPNQRYRSIDPYRGPG 183

  Fly   209 -----------IEGSENDICS------------------------------TMR----------- 221
                       :.||::|:.|                              |.|
Frog   184 YGPQPQVRGGGLGGSQSDLLSGRVYGSEDAYGLEDDRRSLGGYIDGPDYATTGRRGANGGDPRRR 248

  Fly   222 -------------------------------------WRDPNLSEVISFLSNPSSAIKANAAAYL 249
                                                 |:.|.|.||::.||....|::.||||||
Frog   249 LRSYEDPLSDRFGSVPTSGSLSSLGPAPLTLAPTSGPWKQPELPEVLAMLSYTLDAVRLNAAAYL 313

  Fly   250 QHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIA 314
            |||.|.::..|:....|.|||||:.||......:...|||||:|||||... |||..:||..|:.
Frog   314 QHLSYRNEDVKKEVCRLRGIPPLISLLEDPRAPVRLAACGALKNLSYGPAR-ENKMAVKNCDGVP 377

  Fly   315 ALVHLLCRSQE----TEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGW------D 369
            ||..||.|..|    .|:.|.|||.|||:||.:.:|..::|:||..:...::.|||||      .
Frog   378 ALARLLHRRGEGKEGRELAECVTGTLWNLSSLDSIKMELVDQALYTLTQEILVPHSGWQQDGVMQ 442

  Fly   370 AVCCGE---TCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTV 431
            .|..|:   ..:.....|.:|.|||:||....||..:|.||.|||.:::::|:.:....:.:|.|
Frog   443 VVVEGKPRHVEWEPALVNTTGCLRNISSERSEARRKMRECEGLVESVVHILRSEVSHGQVDSKLV 507

  Fly   432 ENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNK-KKKEANNSDALNEY 495
            ||.||:||||||.... :.|:.:|:....|.    :|::.:|..|||..: |.|:|:....::
Frog   508 ENVVCLLRNLSYHIHR-EIPHAEKYMENPPN----ASAETQNPSCFGVRRGKGKKASEESVVD-- 565

  Fly   496 NISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSID 560
              :.|:.|.::.    .:||:.|:|||:|:.|:||::....|..|||:|||||||.|..|.....
Frog   566 --TIDFPKRTMP----AQGYDLLFQPEIVRLYISLVKLSHTPAVLEASAGAIQNLCAGNWVYGRC 624

  Fly   561 IRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQH 625
            |||.||:||||..|.:.|..|.:|||.|:..|||||..|.||:|||||:|:..||.:|.|.:.|
Frog   625 IRAAVRQEKGLSSLADHLTHESERVVRAICGALRNLCGDSRNRELIGKHALNSLVARLSSSSAQ- 688

  Fly   626 DQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITK---RKEKYTSCVLKFASQVLY 687
            ....|:||...|::||:|||..|.|.::.|.:|.||:||:.|.|   |.:|    .::.|...|.
Frog   689 SSALSEDTNVGVISTIHEVISGNLEAAKRLRESQGIERLVLINKGGGRSDK----EIRAAGFCLQ 749

  Fly   688 TMWQHNELRDVYKKNGWKEQDF-VSKHFTAH------NTPPSSPNNVNNTLNRPMASQGRTRYED 745
            |:|.:.|||...:|:|||..|| ||...|:.      :|.|....|:.|        :.::...|
Frog   750 TIWGYKELRRPLEKDGWKRNDFQVSTAVTSRVQVYDDSTLPLIDRNLKN--------EKKSENTD 806

  Fly   746 RTIQRGTSTLYSANDSSGAVMSNESAMLSEM 776
            ..:....:..::.|..|...:.|.|..|||:
Frog   807 IPLNDFRTDPFAHNGDSSNRLPNRSEELSEL 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	55/117 (47%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	16/35 (46%)
		armadillo repeat	304..339	CDD:293788	17/38 (45%)
		ARM	307..442	CDD:237987	55/147 (37%)
		armadillo repeat	347..392	CDD:293788	14/53 (26%)
		armadillo repeat	515..556	CDD:293788	21/40 (53%)
		ARM	516..643	CDD:237987	62/126 (49%)
		armadillo repeat	562..596	CDD:293788	18/33 (55%)
		armadillo repeat	601..641	CDD:293788	17/39 (44%)
ctnnd1	NP_001119545.1	ARM	286..408	CDD:237987	57/122 (47%)
		armadillo repeat	291..316	CDD:293788	13/24 (54%)
		armadillo repeat	324..360	CDD:293788	16/35 (46%)
		armadillo repeat	367..406	CDD:293788	17/38 (45%)
		armadillo repeat	413..468	CDD:293788	15/54 (28%)
		ARM	455..>520	CDD:237987	27/64 (42%)
		ARM	580..>674	CDD:237987	50/93 (54%)
		armadillo repeat	582..616	CDD:293788	19/33 (58%)
		armadillo repeat	626..660	CDD:293788	18/33 (55%)
		armadillo repeat	715..751	CDD:293788	12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1705
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060