DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and arvcf

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_031748274.1	Gene:	arvcf / 100038219	XenbaseID:	XB-GENE-489677	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	727	Identity:	278/727 - (38%)
Similarity:	384/727 - (52%)	Gaps:	145/727 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 YTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQR 201
            |..|.:|:.:........|.:|||             .:.|.:....|..|
Frog   302 YELDPDYSTMNRRVLPGMPLTGRP-------------HKARAYDDPLEADL-------------- 339

  Fly   202 LEEKDDYIEG-------------------------SENDICSTMRWRDPNLSEVISFLSNPSSAI 241
            :||:..|:.|                         |.:.|....|||||:|.|||:.|::|...:
Frog   340 IEERIPYLHGGYAAPLAQPERGSLASIDRLGKRSPSIDSIRKDPRWRDPDLPEVIAMLNHPIDPV 404

  Fly   242 KANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRG 306
            |:|||||||||||.:|..|:..|.|.|||.||.||.:..||:|:.|||||||:|||:.| |||..
Frog   405 KSNAAAYLQHLCYENDKIKKDVRYLKGIPTLVGLLDHPKPEVHRKACGALRNISYGKDN-ENKVA 468

  Fly   307 IKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGW--- 368
            |||..||.||:.||.::.:.||:||:||.|||:||.|.||..||:..|..:...||.|||||
Frog   469 IKNCDGIPALIRLLRKTNDMEVRELITGTLWNLSSYEPLKMVIINHGLQTLTNEVIIPHSGWENE 533

  Fly   369 --------DAVCCGETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNN 425
                    ||.      :||||:|.||.||||||.|..||..||.|:.||:.||:.:::::.|.:
Frog   534 PNEDSKPRDAE------WSTVFKNTSGCLRNVSSDGAEARRRLRECDGLVDALLHALQSAVSKKD 592

  Fly   426 IGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVI--------PSSSKGENLGCFGTNKK 482
            ..||:|||||||:|||||...: :.|..|:.    .|..:        ....|.::.||||..|.
Frog   593 TDNKSVENCVCIMRNLSYHVHK-EVPGADRF----QENELNQQGGIGGQQKKKKDDAGCFGGKKA 652

  Fly   483 KKE-----ANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEA 542
            |:|     ..|.|....:: :.|..|.|    :..||:|.|:|||||:.|||:|....|..||||
Frog   653 KEEWFNQGKKNGDTDKNFD-TLDLPKRS----ESAKGFELLYQPEVVRLYLSILTESQNYNTLEA 712

  Fly   543 AAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIG 607
            ||||:|||||..|..|..||||||||:|||:|||||:.:.|:||.|||.|||||::|:|||:|||
Frog   713 AAGALQNLSAGNWTWSTYIRATVRKERGLPVLVELLQSDSDKVVRAVAIALRNLSMDRRNKDLIG 777

  Fly   608 KYAMRDLVQKLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKE 672
            .|||..||:.||.|..:..:|..:||:.|||.||:|:|..:.|.:|||:.:.||::|:.|.|..:
Frog   778 NYAMGQLVRNLPGGQQRPAKNLEEDTVVAVLNTIHEIITDSSENARSLIQTQGIEKLITINKSSQ 842

  Fly   673 KYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTAHNT-PPSSPNNVNNTLNRPMA 736
            ....  :|.||.||..:|.:.|||...:|.||.:.:|.    ||.:| |..|..|
Frog   843 SPRE--VKAASHVLQMVWSYKELRGALQKEGWNKANFQ----TAVSTLPKGSKGN---------- 891

  Fly   737 SQGRTRYEDRTI------------------------QRGTSTL--------YSANDSSGAVMSNE 769
              |::.::|.|:                        ..|.||:        |.:|:|.|. ||.:
Frog   892 --GKSGFDDSTLPLVDKSQVNKKSGSRDMIPMGELGPDGYSTIDHRDKERKYRSNESMGD-MSEK 953

  Fly   770 SAMLSEMVRKQL 781
            ..:.::..:|.:
Frog   954 EPLKNDSNKKHI 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	64/113 (57%)
		armadillo repeat	227..252	CDD:293788	14/24 (58%)
		armadillo repeat	260..296	CDD:293788	20/35 (57%)
		armadillo repeat	304..339	CDD:293788	18/34 (53%)
		ARM	307..442	CDD:237987	70/145 (48%)
		armadillo repeat	347..392	CDD:293788	21/55 (38%)
		armadillo repeat	515..556	CDD:293788	25/40 (63%)
		ARM	516..643	CDD:237987	77/126 (61%)
		armadillo repeat	562..596	CDD:293788	24/33 (73%)
		armadillo repeat	601..641	CDD:293788	20/39 (51%)
arvcf	XP_031748274.1	armadillo repeat	390..415	CDD:293788	14/24 (58%)
		ARM	419..459	CDD:214547	21/39 (54%)
		armadillo repeat	423..459	CDD:293788	20/35 (57%)
		Arm	462..503	CDD:395413	22/41 (54%)
		armadillo repeat	466..501	CDD:293788	18/34 (53%)
		armadillo repeat	508..559	CDD:293788	22/56 (39%)
		HEAT_2	678..764	CDD:404525	53/89 (60%)
		armadillo repeat	686..722	CDD:293788	23/35 (66%)
		ARM	728..767	CDD:214547	27/38 (71%)
		armadillo repeat	732..766	CDD:293788	24/33 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1705
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48613
Panther	1	1.100	-	-	O	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160