DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17883 and Tbc1d20

DIOPT Version :9

Sequence 1:	NP_001036448.1	Gene:	CG17883 / 3355139	FlyBaseID:	FBgn0040005	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	XP_038961410.1	Gene:	Tbc1d20 / 362237	RGDID:	1303293	Length:	441	Species:	Rattus norvegicus

Alignment Length:	312	Identity:	133/312 - (42%)
Similarity:	192/312 - (61%)	Gaps:	17/312 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CPESDDEL-------KKRLEIEKLINKNIDKNISFDV--LVKLSLAPYGLVNDDFRRILWPQLAG 69
            ||..:..:       ||..||.:.:|.:     ..||  |.:::::..||:.|:.|..:||:|..
  Rat    54 CPVPETPVDFNAKRKKKVAEIHQALNSD-----PTDVAALRRMAISEGGLLTDEIRCQVWPKLLN 113

  Fly    70 VDINHLGQAPTLDKFQCHPEYNQVVLDVNRSLKRFPPGIPYEQRIALQDQLTVLILRVIQKYPNL 134
            |:.:........|......:|.||:|||.|||:|||||:|.|||..||::|..:||.|:.:.|.|
  Rat   114 VNTDEPPPMSRKDLRDMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLVLDRNPQL 178

  Fly   135 RYYQGYHDVAVTFLLVVGEEIAFAIMEQLSTTHFSECMQETMEATQRRLMFIWPIIKFENPELYQ 199
            .|||||||:.|||||||||.:|.:::|:|||.|..:.|..||:.|:..|.::.|||...||||:.
  Rat   179 HYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHD 243

  Fly   200 FLQNSTVGTLFSLPWYLTWFGHSLTSYRTVVRLYDYFLASPIYTSIFVTAAILLYRSDEILKEDC 264
            |:|::.|||:|:|.|.:|||||.|..:|.||||||:|||......|:..|.|:|||..|:|..||
  Rat   244 FMQSAEVGTIFALSWLITWFGHVLLDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDC 308

  Fly   265 DMASVHCLLSVIPEDLPFEDLLKTSSSLLNKYSLTLIEKDVEELICQERRKR 316
            ||||||.|||.||:|||:|.|:..:..|..::..:.:.:   |...|:..:|
  Rat   309 DMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELAR---EAAAQQEAER 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17883	NP_001036448.1	RabGAP-TBC	91..260	CDD:278964	90/168 (54%)
Tbc1d20	XP_038961410.1	RabGAP-TBC	101..304	CDD:366170	98/202 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353931
Domainoid	1	1.000	197	1.000	Domainoid score	I3022
eggNOG	1	0.900	-	-		E1_KOG2595
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32574
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3185
OMA	1	1.010	-	-		QHG54480
OrthoDB	1	1.010	-	-		D1107565at2759
OrthoFinder	1	1.000	-	-		FOG0003660
OrthoInspector	1	1.000	-	-		oto98462
orthoMCL	1	0.900	-	-		OOG6_103152
Panther	1	1.100	-	-	O	PTHR20913
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2532
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770