DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17883 and TBC1D20

DIOPT Version :9

Sequence 1:	NP_001036448.1	Gene:	CG17883 / 3355139	FlyBaseID:	FBgn0040005	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_653229.1	Gene:	TBC1D20 / 128637	HGNCID:	16133	Length:	403	Species:	Homo sapiens

Alignment Length:	307	Identity:	134/307 - (43%)
Similarity:	196/307 - (63%)	Gaps:	10/307 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EKCPESDDELKKRLEIEKLINKNIDKNISFDV--LVKLSLAPYGLVNDDFRRILWPQLAGVDINH 74
            ||...:....||..||.:.:|.:     ..||  |.:::::..||:.|:.||.:||:|..|:.|.
Human    21 EKADFNAKRKKKVAEIHQALNSD-----PTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNAND 80

  Fly    75 LGQAPTLDKFQCHPEYNQVVLDVNRSLKRFPPGIPYEQRIALQDQLTVLILRVIQKYPNLRYYQG 139
            .......:..|...:|.||:|||.|||:|||||:|.|||..||::|..:||.::::.|.|.||||
Human    81 PPPISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHYYQG 145

  Fly   140 YHDVAVTFLLVVGEEIAFAIMEQLSTTHFSECMQETMEATQRRLMFIWPIIKFENPELYQFLQNS 204
            |||:.|||||||||.:|.:::|:|||.|..:.|..||:.|:..|.::.|||...||||:.|:|::
Human   146 YHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPELHDFMQSA 210

  Fly   205 TVGTLFSLPWYLTWFGHSLTSYRTVVRLYDYFLASPIYTSIFVTAAILLYRSDEILKEDCDMASV 269
            .|||:|:|.|.:|||||.|:.:|.||||||:|||......|:..|.|:|||..|:|..|||||||
Human   211 EVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLYREQEVLDCDCDMASV 275

  Fly   270 HCLLSVIPEDLPFEDLLKTSSSLLNKYSLTLIEKDVEELICQERRKR 316
            |.|||.||:|||:|.|:..:..|..::..:.:.:   |...|::.:|
Human   276 HHLLSQIPQDLPYETLISRAGDLFVQFPPSELAR---EAAAQQQAER 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17883	NP_001036448.1	RabGAP-TBC	91..260	CDD:278964	89/168 (53%)
TBC1D20	NP_653229.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		2/3 (67%)
TBC1D20	NP_653229.1	RabGAP-TBC	63..266	CDD:306939	99/202 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159867
Domainoid	1	1.000	203	1.000	Domainoid score	I2984
eggNOG	1	0.900	-	-		E1_KOG2595
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32574
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3219
Isobase	1	0.950	-	0	Normalized mean entropy	S3290
OMA	1	1.010	-	-		QHG54480
OrthoDB	1	1.010	-	-		D1107565at2759
OrthoFinder	1	1.000	-	-		FOG0003660
OrthoInspector	1	1.000	-	-		oto91382
orthoMCL	1	0.900	-	-		OOG6_103152
Panther	1	1.100	-	-	O	PTHR20913
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R538
SonicParanoid	1	1.000	-	-		X2532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750