DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17486 and asnsd1

DIOPT Version :9

Sequence 1:	NP_001036446.2	Gene:	CG17486 / 3355138	FlyBaseID:	FBgn0032997	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_956389.2	Gene:	asnsd1 / 368827	ZFINID:	ZDB-GENE-030616-362	Length:	611	Species:	Danio rerio

Alignment Length:	624	Identity:	212/624 - (33%)
Similarity:	312/624 - (50%)	Gaps:	83/624 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCGIFCSVVNNVPLNSFNISSALKVILKNRGPDVQDEVVIDYCFGKILFAGFVLWQQGESVQKQP 65
            ||||.|.|....|.:.  :...:...||:|||:...::..:.....:||:..||..:| .:..||
Zfish     1 MCGICCVVSLTTPHDP--LEENVLQNLKHRGPNCSKDITKEISNCSVLFSAHVLHMRG-CLTPQP 62

  Fly    66 VVED-DFIFLFNGDIYNTSKPEYMSDTTWIAERLAECRCKEQNILKILKRLEGPHCLIIYDKREQ 129
            :.:| ..:.|:||:::...|.|...:.|.:............:|:.:|.:||||...|.|.|.|:
Zfish    63 LQDDTGNMLLWNGEVFGGLKLEQEENDTKVLLHQLSMATSASDIVCLLSQLEGPWAFIYYQKSER 127

  Fly   130 ILYFSRDALGRNSLL----IERICNGFQLLSTSH--FEDKKIS-LELPPLGLFRVKLNDLN---- 183
            .::|.||..||.|||    .||..  |.|:|.:.  .:|.:.. .|:||.|::|..|.|.:
Zfish   128 CIWFGRDFFGRRSLLWKFNPERAF--FTLVSVASQPADDSQSQWQEVPPGGVYRFDLTDTSLDGT 190

  Fly   184 -SCVLYPW------QPLNNYSTQL-LRNLDLAIGWKT-----AVESPMSPDWMLNCNPAFSYNFY 235
             ...||||      :|:.  |.:| ...|...:...|     .:.||:.|   :|.:.:......
Zfish   191 FIFELYPWIFHSDDKPIE--SPELKCEGLPKCVSLNTNSSGLYLTSPVCP---MNTSISSLTTEQ 250

  Fly   236 EFQYIKNNVNLYKNLIDQSEIKYTLSILHTLLSDSIKNRVRNMAPFCRLCMQKLNISPPCRHAKL 300
            .....:.:|...|..:..::.|..:|.|..:||::::.||:.:.     ....|.:|.....|.:
Zfish   251 NHNASQTSVENLKAFLTNTDKKAVVSALIDVLSEAVRKRVQYLH-----ARDALEVSLNQTKADI 310

  Fly   301 CILFSGGLDCTILALLANQFVPVNEPIELINVAFE----------SVKGQN-------------I 342
            .||||||:|..|||.|.::.||.::||:|:||||:          ..||:|             .
Zfish   311 AILFSGGIDSMILAALTDRHVPADKPIDLLNVAFKMQEAKMPPKSMKKGKNKKTDCDDADKTQLD 375

  Fly   343 SEKL--FDVPDRKTSLVSVNELKQLCPERCWNLLKVNVTRLELQQHLTSRIKHLIYPLDTVLDES 405
            .:|.  |:||||.|....:.|||.|.|:|.||.:::|||:.||.:....||.||::|||||||:|
Zfish   376 QQKFNPFNVPDRITGRAGLQELKNLSPKRQWNFIEINVTQEELVEMRQKRICHLVHPLDTVLDDS 440

  Fly   406 LGCAFWFAS------------HCTHSTARVALIGSGADELFGGYTRYRNSYSRCLGNDLERQLAV 458
            ||||.|||:            ....|.|:|.|.|.||||...||:|:|..|.......|.|:||:
Zfish   441 LGCAIWFAARGIGVINEAVDEELYISEAKVVLTGIGADEQLAGYSRHRVRYKHSGLEGLIRELAM 505

  Fly   459 QNELERDWQRISARNLARDDRIIADTGKTARSPFIEENFVKFIRSLEVYQKCCFGFPEGVGDKLL 523
                  :..|||:|||.||||||.|.||.||.|:::|:.|.|:..|.|.:|.....|.|||:|||
Zfish   506 ------ELGRISSRNLGRDDRIIGDHGKEARFPYLDEDVVSFLNGLPVSEKADLSLPRGVGEKLL 564

  Fly   524 LRLYGYQIGLRDVVFLKKRAIQFGSRIANKKQNGSHQSD 562
            |||...::||.....|.|||:|||||||..:.|....||
Zfish   565 LRLAAVELGLGLSALLPKRAMQFGSRIAKLEDNHEKASD 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17486	NP_001036446.2	Gn_AT_II_novel	1..175	CDD:239735	54/181 (30%)
CG17486	NP_001036446.2	Asn_Synthase_B_C	266..547	CDD:238949	128/317 (40%)
asnsd1	NP_956389.2	Gn_AT_II_novel	1..178	CDD:239735	54/181 (30%)
asnsd1	NP_956389.2	Asn_Synthase_B_C	280..588	CDD:238949	128/318 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581852
Domainoid	1	1.000	126	1.000	Domainoid score	I5378
eggNOG	1	0.900	-	-		E1_COG0367
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6564
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2913
OMA	1	1.010	-	-		QHG55715
OrthoDB	1	1.010	-	-		D379771at33208
OrthoFinder	1	1.000	-	-		FOG0004855
OrthoInspector	1	1.000	-	-		oto41671
orthoMCL	1	0.900	-	-		OOG6_102544
Panther	1	1.100	-	-	LDO	PTHR45937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R96
SonicParanoid	1	1.000	-	-		X3425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800