Protein Alignment Nipped-B and SCC2

DIOPT Version :9

• Sequence 1: NP_001036451.1
• Gene: Nipped-B / 3355136
• FlyBaseID: FBgn0026401
• Length: 2077
• Species: Drosophila melanogaster
• Sequence 2: NP_010466.3
• Gene: SCC2 / 851761
• SGDID: S000002588
• Length: 1493
• Species: Saccharomyces cerevisiae
• Alignment Length: 1714
• Identity: 346/1714 - (20%)
• Similarity: 617/1714 - (35%)
• Gaps: 453/1714 - (26%)

  Fly   351 TSTSTSSSGKSQVRVCINRLSIEDSRLMQQSIKKFVQKSPELARSMGLLQETCQQQHENLNIIPT 415
            |:.||:||.|::.         |..||:.:....|...:                  .:::.:||
Yeast    67 TANSTTSSIKNEA---------EKERLVFKRPSNFTSSA------------------NSVDYVPT 104

  Fly   416 SAEECVLESRASSTNNTVKIPIDTFSTIKADE---KRSAKRKL---AISIGDIPPEQIFSKPKMR 474
            :..| .|...|.|..:|.|...|:.:..|..|   :..||.||   ..:.|::......|..|.:
Yeast   105 NFLE-GLSPLAQSVLSTHKGLNDSINIEKKSEIVSRPEAKHKLESVTSNAGNLSFNDNSSNKKTK 168

  Fly   475 RVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNFDSEDVDETIECISSKLLNS 539
            ....:|           :|::...:|::.::.:|::|:      .||..
Yeast   169 TSTGVT-----------MTQANLAEQYLNDLKNILDIV------GFDQN---------------- 200

  Fly   540 MSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVYLARNYFAGTEDEDEFVDDEVIEKLLNAMDAC 604
             |.::..::....|   |..|..|..|...:.....:|    ..|..:..:...|..||..:|
Yeast   201 -SAEIGNIEYWLQL---PNKKFVLTTNCLTKLQMTIKN----ITDNPQLSNSIEITWLLRLLD-- 255

  Fly   605 LLICNIYSTVSDLQFLQEDN-------VSHIIKFTQFQLRETIFPLHDPVYTAKSIKRTTHRKKI 662
            :::|||..:.|.|:...:|:       :|.|:.|..|.|.:....||...|..:.:.
Yeast   256 VMVCNIKFSKSSLKMGLDDSMLRYIALLSTIVLFNIFLLGKNDSNLHRESYIMEPVN-------- 312

  Fly   663 KSHQAQNRSMQLFYLKTVELLKVFVTL--------FDKCVFVDTIVLPLSTLAIEPFFVDNI--- 716
                        |....:|.||: :|:        ||  .|.:.:.|....:...||..||:
Yeast   313 ------------FLSDLIESLKI-LTIEYGSLKIEFD--TFQEALELLPKYIRNGPFLDDNVTAK 362

  Fly   717 -----------------ETLQF---------VCLELVTTIFRKERYDKIRNSILGDILTSIDRLP 755
                             ..:||         :..:::.::|..  :|:.|..|:.::|:.|::||
Yeast   363 LVYIFSDLLMNNDIEATTNIQFQSFWDNVKRISSDILVSLFGS--FDQQRGFIIEELLSHIEKLP 425

  Fly   756 SSK--KNLRPYKLTNNGGNIQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLL 818
            :.:  |.||  |:.|....|...|..::.:::  .|...|.|:..| ...|:..:....|.||
Yeast   426 TKRIQKKLR--KVGNQNIYITDFTFTLMSMLE--NINCYSFCNQMK-DIAPENIDLLKNEYKK-- 483

  Fly   819 QPSQDLLVLQKYDVAVSIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASE-L 882
              .::.|    :::...|....|..|.      .|.:..|.:.:||:.|||..::.|:||.:| :
Yeast   484 --QEEFL----FNIVEHINDTILERFF------KNPSALRYVIDNFVQDLLLLISSPQWPVTEKI 536

  Fly   883 LLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKE 947
            |.|||..:|..|.....:..:|..:.|..:|                  .|.|.|..||......
Yeast   537 LSSLLKRLLSVYSPSMQVSANIETICLQLIG------------------NIGSTIFDIKCSTRDH 583

  Fly   948 GDVTSNNDQFDLEPEEQRTDFLQKILLDFLAVNAQEENLIWDYARHFYLAQWYRDVIYQRRRIND 1012
            .|   ||              |.|:      :|..|.      ..||:.:  :.:.|.....|..
Yeast   584 ED---NN--------------LIKM------INYPET------LPHFFKS--FEECIAYNETIKC 617

  Fly  1013 GKKGLAFRKSKIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARK 1077
            .:....|    :.|.|.  |..|..       |..|...|::|..||:             |.:|
Yeast   618 RRSATRF----LWNLRL--GTILIL-------EEYTKDAKEQIITVDN-------------ELKK 656

  Fly  1078 QYFINKIKPFSVFGE-QNHSSNQHIKTYIDYNNAQLIAQYLATKRPFS--QSFDGCLKKIILVVN 1139
              .:.:||...:..| :|..:        |::..:|  .|.:....|.  ..:|..||.|:.::.
Yeast   657 --ILEQIKDGGLGPELENREA--------DFSTIKL--DYFSILHAFELLNLYDPYLKLILSLLA 709

  Fly  1140 EPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLID 1204
            :..|.:|:.|:|||:.:...|.::|....::..::::..|::.||::|.:|||     |......
Yeast   710 KDKIKLRSTAIKCLSMLASKDKVILSNPMVKETIHRRLNDSSASVKDAILDLV-----SINSSYF 769

  Fly  1205 QYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEE-GIQKLVTEVFM 1268
            ::|..::....|..:.|||.|::|...:..|..|......:..:::.::.||| .|..:...:.:
Yeast   770 EFYQQINNNYNDDSIMVRKHVLRINEKMYDETNDIVTKVYVIARILMKIEDEEDNIIDMARLILL 834

  Fly  1269 KMWFTPCTKNDKIGIQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEF---- 1329
            ..|..            |::.::|......:..::.|  |:||..     .:.:|.|.|.|
Yeast   835 NRWIL------------KVHEVLDQPEKLKEISSSVL--LVMSRV-----AIMNEKCSQLFDLFL 880

  Fly  1330 ----IKK--NSEPPMD-IVIACQQLADGLVDRLIELEDTDNSRMLGCI---TTLHLLAKVRPQ-- 1382
                :.|  :|:...| |......|.|.||.:::||...|.:.....:   ..|:||||....
Yeast   881 NFYLLNKEAHSKEAYDKITHVLTILTDFLVQKIVELNSDDTNEKNSIVDKQNFLNLLAKFADSTV 945

  Fly  1383 --LLVKHAITIEPYL----NIKCHSATAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLV 1441
              |...|...:.||:    ....|......|.|.    .||:.    |..:.||..||..|:..:
Yeast   946 SFLTKDHITALYPYMVSDEKSDFHYYILQVFRCT----FEKLA----NFKQKFLYDLETTLLSRL 1002

  Fly  1442 VSRNQAEVTSCVSCLGALVNKITHNF------KLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYT 1500
            ...|..|:...:..:.::.   ||..      |....|....:..::       :.||....|..
Yeast  1003 PKMNVREIDEAMPLIWSVA---THRHDTARVAKACSSCLSHLHPYIN-------KANNEEAAIVV 1057

  Fly  1501 PSFRRSLFTIGILMRYFDFKSP----IAL---GETNDGLPVSICEDVFHCLMFFCR-CTNQEIRK 1557
            ....:.|..:......|.|..|    ||.   |||       :.|.:..||:...: .....||:
Yeast  1058 DGKLQRLIYLSTGFARFCFPKPSNDKIAFLQEGET-------LYEHITKCLLVLSKDKITHVIRR 1115

  Fly  1558 QALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGFKIICMRNIW-IYLTESEMFMHNKEKE 1621
            .|:.:|...|..:........:.:|..:...|  :....|::.:.::: ::|.|....:.|....
Yeast  1116 VAVKNLTKLCGNHPKLFNSRHVLHLLDKEFQS--DQLDIKLVILESLYDLFLLEERKSVRNTGVN 1178

  Fly  1622 WEKQSK---HEDLKEMNDV---SSGMASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGL 1680
            ....|.   .:.|.:.|.|   :.|:.|.:...:|:.||:..|.||....|.|:::::::|:.|.
Yeast  1179 STLSSNSILKKKLLKTNRVEFANDGVCSALATRFLDNILQLCLLRDLKNSLVAIRLLKLILKFGY 1243

  Fly  1681 VHPVRMVPYLICL--STDHRIESAHRADALLKDIDKTYSGFVNMKVQFGL--------------- 1728
            .:|...:|.:|.|  ||...|.  |.|..||:|:.:.|...|...:..|:
Yeast  1244 TNPSHSIPTVIALFASTSQYIR--HVAYELLEDLFEKYETLVFSSLSRGVTKAIHYSIHTDEKYY 1306

  Fly  1729 -----------QLC----------FK-LQKILQINNRGKLEIIRGYASRGP-------------D 1758
                       :||          || |::|:|    ..|:.|....|...             .
Yeast  1307 YKHDHFLSLLEKLCGTGKKNGPKFFKVLKRIMQ----SYLDDITDLTSTNSSVQKSIFVLCTNIS 1367

  Fly  1759 NTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQKTSLQQMLYIADNLAYFPYVVQDEPLYLIH 1823
            |.|......|.:||:|.......|.:.:..:..|..:||.               |.:|.|..|.
Yeast  1368 NITFVSQYDLVSLLKTIDLTTDRLKEVIMDEIGDNVSSLS---------------VSEEKLSGII 1417

  Fly  1824 QIDLLISMAGTHLLATFKEHIKPSDKEGDVLEDD----DDVEDPEVLFNRLPEDLTEIIKCITSA 1884
            .|.|.:...||:||..:.            |.||    |.||:.|:...:||....:|.|  .||
Yeast  1418 LIQLSLQDLGTYLLHLYG------------LRDDVLLLDIVEESELKNKQLPAKKPDISK--FSA 1468

  Fly  1885 QA---------CMLLLILKDHLKE 1899
            |.         ..||...:.|:|:
Yeast  1469 QLENIEQYSSNGKLLTYFRKHVKD 1492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-B	NP_001036451.1	Cohesin_HEAT	1151..1192	CDD:289531	10/40 (25%)
		Nipped-B_C	1643..1826	CDD:289591	50/234 (21%)
SCC2	NP_010466.3	Cohesin_HEAT	721..762	CDD:403845	10/40 (25%)
		Nipped-B_C	1207..1384	CDD:403897	40/182 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1020
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I1163
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003400
OrthoInspector	1	1.000	-	-		oto100273
orthoMCL	1	0.900	-	-		OOG6_103308
Panther	1	1.100	-	-	LDO	PTHR21704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R719
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.820