DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nipped-B and EMB2773

DIOPT Version :9

Sequence 1:	NP_001036451.1	Gene:	Nipped-B / 3355136	FlyBaseID:	FBgn0026401	Length:	2077	Species:	Drosophila melanogaster
Sequence 2:	NP_197058.2	Gene:	EMB2773 / 831407	AraportID:	AT5G15540	Length:	1846	Species:	Arabidopsis thaliana

Alignment Length:	1949	Identity:	442/1949 - (22%)
Similarity:	799/1949 - (40%)	Gaps:	534/1949 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 IKKFVQKSPELARSM------GLLQ----ETCQQQHENL-NIIPTSAEECVLESRASSTNNTVKI 435
            :|...|....||||:      .:|:    |....|||.| |..|  .:....:||..:.
plant   150 VKMQRQTDTHLARSIEPEPVKRVLRPNHVEDHSWQHETLTNQSP--KDVTAYDSRPETI------ 206

  Fly   436 PIDTFSTIKADEKRSAKRKLAISIGDIPPEQIFSKPKMRRVERITPLSNTKCVKEEVTRSQTYQQ 500
               |.:.:.|.:|...|:|....:..:.|:....:..:  |:....:....|.:.||..
plant   207 ---TMNELSASKKPKGKKKRKDDLSSVQPDPSVLQESI--VQNFCEMLEDFCGRAEVPG------ 260

  Fly   501 FIRNMDHIIEILDDSESPNFDSEDVDETIECISSKLLNSMSTDVAKLKAKQALDSIPKNKLTLLI 565
                        ||.:...:.|..|||.     ..|:|.:.|    :::|..|..:|.:.|:.|:
plant   261 ------------DDRDEAEWSSVPVDEV-----RVLINELMT----IRSKMLLHMVPVDILSRLL 304

  Fly   566 NYAMRNVYLARNYFAGTEDEDEFVDDEVIEKLLNAMDACLLICNIYSTV-----SDL--QFLQED 623
            ......::.|.    |.....|..|.:.:..:|.|::      :|::::     ||:  |..:|:
plant   305 RTLDHQIHRAE----GLSIYSEHSDSDSVLLVLGALE------SIHASLAVMANSDMPKQLYKEE 359

  Fly   624 NVSHIIKFTQFQLRETIFPLHDPVY--------------------------TAKSIKRTTHRKKI 662
            .:..|::|::.|:. .:...:||.|                          :|...:|.....|:
plant   360 IIERILEFSRHQMM-AVMSAYDPSYRTGSKPAENLAFEGDDDDDNPDHDMGSASKRRRIVKNSKV 423

  Fly   663 KSHQ------AQNRSMQ-----LFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVDNI 716
            |...      |.|.::|     |..||.:.|::   .|.|.|      :|.|...:|..|.|:||
plant   424 KKASVNRISGAVNTALQKLCTILGLLKDLLLVE---RLSDSC------ILQLLKTSITTFLVENI 479

  Fly   717 ETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTN-NGGNIQMVTALV 780
            :.||...:.|:..|:..  |.:.|..::.:|...:.:|||||:.||.|.|.: ....|||||||:
plant   480 QILQLKAISLIGGIYNS--YSQHRTYVIDEISQLLWKLPSSKRALRAYLLPDEEQRQIQMVTALL 542

  Fly   781 LQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQK-YDVAVSIGGNFLTTF 844
            :||:..:|.||::       |.:...||:       :|:.|.|:..|.| ::.|......|.|..
plant   543 IQLVHNSTSLPET-------SRQAASGNS-------ILETSVDVGYLTKCHEAATETCCLFWTRV 593

  Fly   845 LNKCKSRSNE--TDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLV 907
            |.:..|...:  ::.:.:.||.:.|||..:|.||:|:...:|.:|..:|:.....|..:.|.|::
plant   594 LERFTSFKGQDASEIKLIIENLVMDLLTALNLPEYPSVSPILEVLCVILLHNAGLKSKDVSARIM 658

  Fly   908 SLDYLGIVAARLRKDTVESRCRVNIIDSMIQS---IKLEQE------------------------ 945
            :::.||.:||||::|.|  .|..:...::::|   |.::|.
plant   659 AIELLGTIAARLKRDAV--LCSKDRFWTLLESDSEISVDQVCTKDCTFCLGKRAGNLLVCQICQR 721

  Fly   946 ---------KEGDVTSNN------------------------DQFDLEPEEQ--------RTDFL 969
                     ||.|::|.|                        ....||.||.        :|:.:
plant   722 RFHGDCLGLKELDISSRNWHCPLCVCKRQLLVLQSYCKTDTKGTGKLESEESIENPSMITKTEVV 786

  Fly   970 QKILLDFLA-VNAQEENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKSKIRNNRRTNGD 1033
            |::||::|. |.:.::  :..:...|||..||:||                .||:
plant   787 QQMLLNYLQDVGSADD--VHTFICWFYLCLWYKDV----------------PKSQ---------- 823

  Fly  1034 YLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPFSVFGEQNHSSN 1098
                                       |.|              :|:|.::|..|:......::
plant   824 ---------------------------NKF--------------KYYIARLKAKSIIRNSGATT- 846

  Fly  1099 QHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLV 1163
                :::..:..:.|...|.....||:.||..|..::..:.|.:..:|.:|::.::.|||.||.|
plant   847 ----SFLTRDAIKQITLALGMNSSFSRGFDKILNMLLASLRENAPNIRAKALRAVSIIVEADPEV 907

  Fly  1164 LKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKI 1228
            |..|.:|:.|..:|.|:||||||||::|||:.:.|:.|:..:|::.::.||.|||||||||.|||
plant   908 LCDKRVQLAVEGRFCDSAISVREAALELVGRHIASHPDVGIKYFEKVAERIKDTGVSVRKRAIKI 972

  Fly  1229 LRDICLEYPDFSKIPEICVKMIRRVHDEE-GIQKLVTEVFMKMW----------FTPCTKNDKIG 1282
            :||:|...|:||:....|.:::.|:.|:| .:|.||.:.|.:.|          |.....:..:.
plant   973 IRDMCTSNPNFSEFTSACAEILSRISDDESSVQDLVCKTFYEFWFEEPPGHHTQFASDASSIPLE 1037

  Fly  1283 IQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEP----PMDIVIA 1343
            :::|...::.:::...:      :.||::|.|        .....:|..:.::.    |:.:...
plant  1038 LEKKTKQMVGLLSRTPN------QQLLVTIIK--------RALALDFFPQAAKAAGINPVALASV 1088

  Fly  1344 ---CQQLADGLVDRLIELEDTDNS----RMLGCITTLHLLAKVRPQLL------VKHAITIEPYL 1395
               |:.:...|:::::::|:....    ::|..:..||....|.|.|.      .|..||::|||
plant  1089 RRRCELMCKCLLEKILQVEEMSREEGEVQVLPYVLVLHAFCLVDPGLCTPASDPTKFVITLQPYL 1153

  Fly  1396 NIKCHSATAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVT-SCVSCLGAL 1459
            ..:..|.|.|:.:.::..|::.|:||:.....|....||:.|..::|..:...|. :||.||.::
plant  1154 KSQADSRTGAQLLESIIFIIDSVLPLIRKLPLSVTEDLEQDLKHMIVRHSFLTVVHACVRCLCSV 1218

  Fly  1460 VNKITHNFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYTPSFRRSLFTIGILMRYFDFKSPIA 1524
            .........::....|.|::.|:.      ||:   ||  |....||||.:|:|:|:.:     :
plant  1219 SKLAGKGVSIVEHLLQFFFKRLEA------QGS---DN--TQIAGRSLFCLGLLIRHGN-----S 1267

  Fly  1525 LGETNDGLPVSICEDVFHCLMFFCRCTNQE---IRKQALISLGSFCVLNDGYLTRSELKNLYCEI 1586
            |..|:.|...::.    .||..|.|....|   ::.::|.:||...:....|:...::..:   |
plant  1268 LISTSGGKNFNLS----GCLNLFKRHLRTEDIALKVRSLQALGFILIARPEYMLEEDIGKI---I 1325

  Fly  1587 LSSIANDAG--FKIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSG--------- 1640
            .:::|::|.  .|:..::|::.||.::|     |:...||.|.:    .:|.|..|
plant  1326 ETTLADEANGRMKMQALQNMYEYLLDAE-----KQLGSEKASDN----TVNSVEQGGHNVPVAAG 1381

  Fly  1641 -----MASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIE 1700
                 :...|:||:.::||...|:.||.:|..::|::::|||||||||:..|||||.|.||.:..
plant  1382 AGDTNICGGIVQLFWDKILGRCLDFDDQIRQTSLKIVEVVLRQGLVHPITCVPYLIALETDPQEA 1446

  Fly  1701 SAHRADALLKDIDKTYSGFVNMKVQFGLQLCF-KLQKILQINNRGKLEIIRGYASRGP------- 1757
            :...|..||.::.:.|..|...::..|||:.| .:|.|.|:.:    |..:....:|.
plant  1447 NQKLAHHLLMNMHEKYPAFFESRLGDGLQMSFIFMQSISQVTS----EPNQSLQQKGSTNMLGKN 1507

  Fly  1758 DNTTTALNDF------LYTLLRTTKPQRRALVQTVTKQFDD---QKTSLQQMLYIADNLAYFPYV 1813
            |:.::.|...      :|.|:|..:..|...:.::.::||:   ..:.:..:.|..:.||..|:.
plant  1508 DHASSTLTQARLGVSRIYKLIRGNRVSRNKFMTSIVRKFDNPTWNGSVISFLKYCTETLALLPFT 1572

  Fly  1814 VQDEPLYLIHQIDLLISM-AGT-----------------HLLATFKE------------------ 1842
            ..||||||::.|:.::.: ||.                 |....:::
plant  1573 SPDEPLYLVYSINRVMQIRAGAVESNLKALLHKDSAKTQHGNGAYQQDPIPGHMNMMDLNTRIQE 1637

  Fly  1843 ---------HIKPSDKEGDVLEDDDD------------------VEDPEVLFNRLPEDLTEI-IK 1879
                     |....|..|.|.:|..|                  ..||..|..   :||.:| :.
plant  1638 EPRHWNSYGHATLIDLNGSVYQDSRDQFTSYQVHNGKADVHKMTSSDPPELST---DDLQKIQVD 1699

  Fly  1880 CITSAQACMLLLILKDHLKEMYAITDSKISRYSPSEQKLYEKAVTRKSVNDFNPKTTIDVIKKQM 1944
            |: :|.|..|||.||.:||..|::.|.:...|||:|.......::|:||       ..|:
plant  1700 CL-AAIAIQLLLKLKRYLKVTYSLNDDRCQAYSPTEPLKPGDPLSRQSV-------AFDL----- 1751

  Fly  1945 SQEKLSTDINFTLTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADESRDKTMLNISASSDGVAFS 2009
              .:..||:..|..     |||.:|.:||..|               |:.|:       |...:|
plant  1752 --SETRTDLPSTYQ-----DLVQRYQEFKNAM---------------REDTV-------DFTIYS 1787

  Fly  2010 SSAKNSHSACDGYSLTVTDVVDVPMSHIAKASMLTSKPSGRKTNPVRTKKKRRKIDSTDDETSD 2073
            ::.|.                              .:|:.|||:....|......|..||:..|
plant  1788 TNVKR------------------------------KRPTPRKTSRSAKKTVAYNEDDDDDDNDD 1821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-B	NP_001036451.1	Cohesin_HEAT	1151..1192	CDD:289531	20/40 (50%)
Nipped-B	NP_001036451.1	Nipped-B_C	1643..1826	CDD:289591	59/199 (30%)
EMB2773	NP_197058.2	PHD	702..748	CDD:279022	5/45 (11%)
		HEAT repeat	874..902	CDD:293787	5/27 (19%)
		Cohesin_HEAT	895..936	CDD:315442	20/40 (50%)
		HEAT repeat	912..940	CDD:293787	15/27 (56%)
		HEAT repeat	949..975	CDD:293787	15/25 (60%)
		HEAT repeat	986..1015	CDD:293787	8/28 (29%)
		Nipped-B_C	1389..1585	CDD:315497	59/199 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1823
eggNOG	1	0.900	-	-		E1_KOG1020
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I560
OMA	1	1.010	-	-		QHG55220
OrthoDB	1	1.010	-	-		D608077at2759
OrthoFinder	1	1.000	-	-		FOG0003400
OrthoInspector	1	1.000	-	-		oto3429
orthoMCL	1	0.900	-	-		OOG6_103308
Panther	1	1.100	-	-	LDO	PTHR21704
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3855
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840