DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nipped-B and nipblb

DIOPT Version :9

Sequence 1:	NP_001036451.1	Gene:	Nipped-B / 3355136	FlyBaseID:	FBgn0026401	Length:	2077	Species:	Drosophila melanogaster
Sequence 2:	XP_009303844.1	Gene:	nipblb / 794108	ZFINID:	ZDB-GENE-030131-6070	Length:	2886	Species:	Danio rerio

Alignment Length:	2040	Identity:	685/2040 - (33%)
Similarity:	1069/2040 - (52%)	Gaps:	329/2040 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KENATEKDKI-DVIENSDLNVTKILSQNTLKKKSNTPERSTVQSIQ--------EQFFIQQQEAN 243
            |:...|::|: |...:.|.:..|..::...:.|....:||...|.:        |:..|:.:.:.
Zfish   926 KDRDKEREKVRDKGRDRDRDQEKKRNKELTEDKQAPEQRSRPNSPRVKQEPRNGEESKIKPERSV 990

  Fly   244 YNLKHDLNQVSTNVGQIQNISDTFPQEPSNFNLNSVNIPNMLYVQSPPFTESEPTQAHHSSIEYL 308
            :  |:..|:.....|:.:|..|  ..:|.:.:..:.:.||.|       ...:.:...:..|..|
Zfish   991 H--KNSNNKDEKRGGENKNQLD--GHKPQSIDSKTADFPNYL-------LGGKSSALKNFVIPKL 1044

  Fly   309 KKKKS----QILDVSILNRQQV-LENTSL-----------HIINKSSTYQTNQNVSTTTSTSTSS 357
            |:.|.    |.:.:.:.:..:| ||...|           .::.|.|..:..:.:|.:.|:.:|.
Zfish  1045 KRDKEGNVMQEVRIELFSEPRVKLEKLDLVEDLNKGAKPVVVLKKLSIDEVQKMISNSRSSKSSR 1109

  Fly   358 SGKSQVRVCINRLSIEDSRLMQQSIKKFVQKSPELARSMGLLQETCQQQHENLNIIPTSAE---- 418
            |...:.|...:||.:.:...|.:..:....:.|:.|.     ..:......::.|.|..::
Zfish  1110 SSHGRFRETDSRLPLCERVKMNKRRRSSTNEKPKYAE-----VSSDDDSSSSVEIAPKRSKKDRD 1169

  Fly   419 ---ECVLESRASSTNNTVKIPIDTFSTIKADEKRSAKRKLAISIGDIPP-------EQIFSKPKM 473
               |...:.|..|.::.     .:|.:.::...|..:|....|..|.||       .::..|.|.
Zfish  1170 KTWEYEEKDRRGSGDHR-----RSFDSRRSSGGRHRERSPEDSDEDSPPPSLSDLARKLKKKEKQ 1229

  Fly   474 RRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNFDSEDVDETIECISSKLLN 538
            ::.:...|    |...:|:..|.|:::|..::|:|::.|:|.:..:.|.:::.:.: .:....|:
Zfish  1230 KKRKAYEP----KLTVDEMMDSSTFKRFTTSVDNILDNLEDVDLTSLDDDEIPQEL-LLGKHQLS 1289

  Fly   539 SMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVY------LARNYFAGTEDEDEFVDDEVIEKL 597
            .:|::.||:||...:..|..:|:..:.:...:|:.      ...|:....:||:....|.::|::
Zfish  1290 ELSSESAKIKAMGIMHKITHDKMVKVQSILEKNIQDGAKLSTLMNHDNDRDDEERLWRDLIMERV 1354

  Fly   598 LNAMDACLLICNIYSTVSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY------------T 649
            ..:.||||...||.::....:.:. ||.:..::::|:|.|:.|::|.:||||            .
Zfish  1355 TKSADACLTALNIMTSARMPKAVYIEDVIERVVQYTKFHLQNTLYPQYDPVYRVDHHGGGTLSSK 1419

  Fly   650 AKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVD 714
            ||..|.:||::::         ..:.|.|..:::.....|.:..:..||.:|.:|:|.|.||||:
Zfish  1420 AKRAKCSTHKQRV---------TVMLYNKVCDIISNLSELLEIQLLTDTTILQISSLGITPFFVE 1475

  Fly   715 NIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTNNGGN-----IQ 774
            |:..||...::|||.:|  .||:|.|..||.:|.||:.|||:||:|||.|:|.::..:     ||
Zfish  1476 NVSELQLCAIKLVTAVF--SRYEKHRQLILEEIFTSLARLPTSKRNLRNYRLNSSDVDGEPMYIQ 1538

  Fly   775 MVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQKYDVAVSIGGN 839
            ||||||||||||..             |.|.:.::.:|..:|:   ..|:|:...|:.|:....|
Zfish  1539 MVTALVLQLIQCVV-------------NLPSDKDSDEENDRKV---DHDVLITNSYETAMRTAQN 1587

  Fly   840 FLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSI 904
            ||:.||.||.|:..|.|:|||||||:.|||:|||||:|||:||||||||.:||...|:|..|.::
Zfish  1588 FLSVFLKKCGSKQGEDDYRPLFENFVQDLLSTVNKPDWPAAELLLSLLGRLLVHQFSNKQTEMAL 1652

  Fly   905 RLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFDLEPEEQRTDFL 969
            |:.||||||.||||||||.|.|              |::|.....:...|...|   |.|:   |
Zfish  1653 RVASLDYLGTVAARLRKDAVTS--------------KMDQRSINRILGENSGSD---EIQQ---L 1697

  Fly   970 QKILLDFLAVNAQEENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKSKIRNNRRTNGDY 1034
            ||.||::|..|.:.:..:. :||.|||||||||.              :....|...::|.:
Zfish  1698 QKALLNYLDENVETDPFLL-FARKFYLAQWYRDT--------------STETEKAMKSQRDD--- 1744

  Fly  1035 LDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIK-PFSVFGEQNHSSN 1098
                     |.||...:.|        |.|....|.:..||||::..:.|| ..|.|.....:|:
Zfish  1745 ---------DSSDGPHHAK--------DVETTSEILQKAEARKKFLRSVIKTTASKFSSLRVNSD 1792

  Fly  1099 QHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLV 1163
            .     :||.::.||.:|||:.|||:||||..|.:|:.|:.|.:|||||:|||||:.:|.|||.:
Zfish  1793 T-----VDYEDSCLIVRYLASMRPFAQSFDIYLTQILRVLGESAIAVRTKAMKCLSEVVAVDPSI 1852

  Fly  1164 LKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKI 1228
            |.|.|||.||:.:.:|.:.|||||||:|:|:||||...|.:||||||..||||||:|||||||||
Zfish  1853 LARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLSRPQLTEQYYDMLIERILDTGISVRKRVIKI 1917

  Fly  1229 LRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKIGIQRKINHIIDV 1293
            |||||||.|.|:|:.|:||||||||:|||||:|||.|.|.|:||||...:||..:.|||.:|.||
Zfish  1918 LRDICLEQPTFNKVTEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPNHDKEAMTRKILNITDV 1982

  Fly  1294 VNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIACQQLADGLVDRLIEL 1358
            |....|:|..|.|.||       .|:|:||   ::...|.:..      ||.||.|.||:.:::.
Zfish  1983 VAACRDSGYDWFEQLL-------QNLLKSE---EDASYKPARK------ACAQLVDSLVEHILKY 2031

  Fly  1359 E----DTDN-----SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSATAAKFICAVADI 1414
            |    |.:|     :|::.|||||:|.:|:||.|:||||:|::|||..||::.:....||.||.|
Zfish  2032 EESLADCENKGLTSNRLVACITTLYLFSKIRPHLMVKHAMTMQPYLTTKCNTQSDFMVICNVAKI 2096

  Fly  1415 LEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYR 1479
            ||.||||:::.|||||.::||.||.|::......|..|||||||:||::|||:|.:..||.::|.
Zfish  2097 LELVVPLMDHPSESFLTTIEEDLMKLIIKYGMTVVQHCVSCLGAVVNRVTHNYKFVWSCFNRYYG 2161

  Fly  1480 VLDVSRSQVIQGNNS---VDNIYTPSFRRSLFTIGILMRYFDFKSPIALGETNDGLPVSICEDVF 1541
            .|...:.|..:..||   |.|  .|:..|||||:|.|.|:|||......|...    |.|.:.|.
Zfish  2162 ALSKLKMQHQEDPNSTVLVSN--KPALLRSLFTVGALCRHFDFDQEEFKGSNK----VVIKDKVL 2220

  Fly  1542 HCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGFKIICMRNIWI 1606
            ..|::|.:..::|::.:|:|.||...:.:.|.:..:|:||||..:|:........||..::|:..
Zfish  2221 ELLLYFTKNDDEEVQTKAIIGLGFLFIQDPGLMFVTEVKNLYNTLLADRKTSVNLKIQVLKNLQT 2285

  Fly  1607 YLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRDDTVRLWAVKV 1671
            ||.|.:..|...::||.|.||.||||||.|:||||:|.|:||||:::||.|.:...:||.:|:.|
Zfish  2286 YLQEEDSRMQEADREWNKLSKKEDLKEMGDISSGMSSSIMQLYLKQVLEAFFHTQSSVRHYALNV 2350

  Fly  1672 IQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQLCFKLQK 1736
            |.:.|.|||:|||:.|||||.:.||......::||..|.:|||.|:||::||...|:::.:::|:
Zfish  2351 IALTLNQGLIHPVQCVPYLIAMGTDSEPTMRNKADQQLVEIDKKYTGFIHMKAVAGMKMSYQVQQ 2415

  Fly  1737 ILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQ-KTSLQQM 1800
            .:.   ..|..:|||:..   |.::|||...|||::|..:..|||.:.::...|||. |:.:..:
Zfish  2416 AIV---GSKDTVIRGFRL---DESSTALCSHLYTMVRGNRQHRRAFLISLLNLFDDNTKSDVNML 2474

  Fly  1801 LYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHI--------------------- 1844
            ||||||||.|||..|:||::::|.:|:.:|::|::||.:|||.:
Zfish  2475 LYIADNLASFPYQTQEEPMFIMHHVDITLSVSGSNLLQSFKESLLKEPRKVEVVKKKKKKKKKKK 2539

  Fly  1845 ---KPSDKEGDVLED--------------------------------------------DDDVED 1862
               |...|.|...||                                            |.||||
Zfish  2540 QKQKRGKKYGSEEEDESSRSSSSSSSSSSSSSDSDSSEEEVIHRRKKPRRTTANSDSDSDLDVED 2604

  Fly  1863 PEVLFNRLPEDLTEIIKCITSAQACMLLLILKDHLKEMYAITDSKISRYSPSEQ-KLYEKAVTRK 1926
            .:.:..|||::...::....::|..:|||:||.|||.:|..:||||.:|||:|. |:|:|||.||
Zfish  2605 VDKVMLRLPDNPEPLLDFANASQGILLLLMLKQHLKNLYGFSDSKIQKYSPTESAKIYDKAVNRK 2669

  Fly  1927 SVNDFNPKTTIDVIKKQMSQEKLSTDINFTLTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADES 1991
            :...|||:.|:|.:...:|...||.|:        |..:|.:|||||.||..||||:.:.:.:.|
Zfish  2670 ANVHFNPRQTLDYLTNSLSNSDLSNDV--------KRRVVRQYLDFKVLMEHLDPDEEEEEGEAS 2726

  Fly  1992 RDKTMLN--ISASSDGVAFSSSAKNSHSACDGYSLTVTDVVDVPMSHIAKASMLTSKPSGRKTNP 2054
            ......|  |:|...|    ||.||  :|.:.|.    |..:|                 .:..|
Zfish  2727 ASSHARNKAINALLGG----SSPKN--NAAESYD----DDSEV-----------------EEKTP 2764

  Fly  2055 VRTKKKRRKIDSTD-----DETSDA 2074
            ..:::.||..||.:     :||.:|
Zfish  2765 GSSRRSRRTGDSAEASGHRNETVEA 2789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-B	NP_001036451.1	Cohesin_HEAT	1151..1192	CDD:289531	22/40 (55%)
Nipped-B	NP_001036451.1	Nipped-B_C	1643..1826	CDD:289591	75/183 (41%)
nipblb	XP_009303844.1	Relaxase	686..933	CDD:304452	2/6 (33%)
		COG1340	693..957	CDD:224259	6/30 (20%)
		PRP38_assoc	837..929	CDD:289628	1/2 (50%)
		DUF4887	902..>1016	CDD:292845	18/93 (19%)
		Cohesin_HEAT	1840..1881	CDD:289531	22/40 (55%)
		HEAT repeat	1857..1885	CDD:293787	15/27 (56%)
		HEAT repeat	1894..1920	CDD:293787	22/25 (88%)
		Nipped-B_C	2326..2500	CDD:289591	73/179 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593118
Domainoid	1	1.000	380	1.000	Domainoid score	I800
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15850
Inparanoid	1	1.050	1078	1.000	Inparanoid score	I238
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003400
OrthoInspector	1	1.000	-	-		otm25156
orthoMCL	1	0.900	-	-		OOG6_103308
Panther	1	1.100	-	-	LDO	PTHR21704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R719
SonicParanoid	1	1.000	-	-		X3855
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.920