DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nipped-B and Nipbl

DIOPT Version :9

Sequence 1:NP_001036451.1 Gene:Nipped-B / 3355136 FlyBaseID:FBgn0026401 Length:2077 Species:Drosophila melanogaster
Sequence 2:NP_081983.2 Gene:Nipbl / 71175 MGIID:1913976 Length:2798 Species:Mus musculus


Alignment Length:2830 Identity:778/2830 - (27%)
Similarity:1198/2830 - (42%) Gaps:931/2830 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DNPTVPVTTLAGLTSTSDLLSELPVADSLQSAASLNKSLLFHALVANESSNLLSMRNENLVRQLV 69
            |.|.||:|||||:.|.:|||::||:...|  .|:..|||||::.:|.|.:.||:.|::|||.|||
Mouse     4 DMPHVPITTLAGIASLTDLLNQLPLPSPL--PATTTKSLLFNSRIAEEVNCLLACRDDNLVSQLV 66

  Fly    70 TAIERTNSDNIEL---------------------------------------------------- 82
            .::.:.::|:|||                                                    
Mouse    67 HSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQN 131

  Fly    83 -IH---------------------CPVQDTATN------------------------------CS 95
             :|                     .|.|.::.|                              .:
Mouse   132 SMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYT 196

  Fly    96 TYPELLQ----------GIYHFRPAVFNTSIKIHSPDQHTANARL------------------EA 132
            |:|::.|          |:.:......:..:..:|.:.|..|.|.                  ::
Mouse   197 THPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSDDYLHMVHRLSSDDGDS 261

  Fly   133 KKMQ-------------------------------IDSYSIP----------------------- 143
            ..|:                               :.|.|:|                       
Mouse   262 STMRNAASFPLRSPQPVCSPAGSDGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQ 326

  Fly   144 -------------------ECYASPTNLSI----------SNEHQLQD----------------- 162
                               :..:|||..|.          |::...||                 
Mouse   327 KKIKLGKDEKDQNEKAAMYDIISSPTKDSTKLTLRLSRVRSSDMDQQDDMLSGMENSNVSENDIP 391

  Fly   163 ------------------------AQACFNQL-----------------TSMTSK---------- 176
                                    |..|.:|.                 ||:.:|          
Mouse   392 FNVQYPGQTSKTPITPQDVNRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVATKQPQTSVVQNQ 456

  Fly   177 ---------------EILEEFSQI---------NFKENATEKDK--------------------- 196
                           :.|.|..:|         .|.:...:|||                     
Mouse   457 QQVSQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGN 521

  Fly   197 --------------------------------------------------------IDVIENSDL 205
                                                                    |.|::...:
Mouse   522 RPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEETKQCNDAPISVLQEDIV 586

  Fly   206 NVTKILSQN---TLKKKSNTPERSTVQSIQEQFFIQQQEANYN---------------------- 245
            ...|.:.:|   |.||||: ||.|..:..|.:..:.:.:.|.|                      
Mouse   587 GSLKSIPENHPETPKKKSD-PELSKSEMKQNESRLSESKPNENQLGESKSNESKLETKTETPTEE 650

  Fly   246 LKHDLNQV-------STNVGQIQNIS---DTFPQEPSNFNLNSVN------IPNMLYVQSP---- 290
            ||.:.|:.       |..|...||.:   ||.|.:....|..|.|      .|.......|    
Mouse   651 LKQNENKTTESKQSESAVVEPKQNENRPCDTKPNDNKQNNTRSENTKARPETPKQKAESRPETPK 715

  Fly   291 -------------------------------------------------------PFTESEPTQA 300
                                                                   |.||.:|..:
Mouse   716 QKSEGRPETPKQKGDGRPETPKQKSEGRPETPKQKGEGRPETPKHRHENRRDSGKPSTEKKPDVS 780

  Fly   301 HH-----SSIEYLKKKKSQIL--------------------------------DVSILNRQQVLE 328
            .|     |....||.::::.|                                |.|.:.|.:.|.
Mouse   781 KHKQDIKSDSPRLKSERAEALKQRPDGRWESLRRDHDSKQKSDDRGESERHRGDQSRVRRPETLR 845

  Fly   329 NTSLH---------------------------------------------IINKS---------- 338
            ::|.:                                             ..|||          
Mouse   846 SSSRNDHSTKSDGSKTEKLERKHRHESGDSRDRPSGEQKSRPDSPRVKQGDTNKSRPGFKSPNSK 910

  Fly   339 STYQTNQNVSTTTSTSTSSSGKSQVR--------------------------------------- 364
            ...:|..|.|...|....:..|::..                                       
Mouse   911 DDKRTEGNRSKVDSNKAHTDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNITQETKKMDMKGE 975

  Fly   365 ---------------------VCINRLSIED-----------SRLMQQSIKKFVQKS-------- 389
                                 |.:.:||::|           ||...:|||....||        
Mouse   976 QKDKVEKMGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREEKSRSSLKSIKNKPSKSNKGSIDQS 1040

  Fly   390 ------PELARSMGLLQETCQQQHENLNIIPTSAEECVLESRASSTNNTVKIPIDTFSTIKADEK 448
                  |||...:......|::...|.....|..|:......:|..:|      |:....::..|
Mouse  1041 VLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN------DSDEAFESSRK 1099

  Fly   449 RSAK-------------------------------------RKLAISIGDI-----PP--EQIFS 469
            |..|                                     |..:.|..|:     ||  .::..
Mouse  1100 RHKKDDDKAWEYEERDRRSSGDHRRSGHSHDGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVAR 1164

  Fly   470 KPKMRRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNF-DSEDVDETIECIS 533
            |.|.:..::.......|...||:..|.|:::|..::::|::.|:|.:...| |.:::.:.: .:.
Mouse  1165 KMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQEL-LLG 1228

  Fly   534 SKLLNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVY------LARNYFAGTEDEDEFVDDE 592
            ...||.:.::.||:||...:|.:..:|...::|...:|:.      ...|:...||:|:....|.
Mouse  1229 KHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDL 1293

  Fly   593 VIEKLLNAMDACLLICNIYSTVSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY-------- 648
            ::|::..:.||||...||.::.:..:.:. ||.:..:|::|:|.|:.|::|.:||||        
Mouse  1294 IMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRVDPHGGG 1358

  Fly   649 ----TAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIE 709
                .||..|.:||::::         :.:.|.|..:::.....|.:..:..||.:|.:|::.|.
Mouse  1359 LLSSKAKRAKCSTHKQRV---------IVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGIT 1414

  Fly   710 PFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTNNGGN-- 772
            ||||:|:..||...::|||.:|  .||:|.|..||.:|.||:.|||:||::||.::|.::..:  
Mouse  1415 PFFVENVSELQLCAIKLVTAVF--SRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDVDGE 1477

  Fly   773 ---IQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQKYDVAV 834
               ||||||||||||||...||.|          .::.|:.::..||:   .||:::...|:.|:
Mouse  1478 PMYIQMVTALVLQLIQCVVHLPSS----------EKDPNSEEDSNKKV---DQDVVITNSYETAM 1529

  Fly   835 SIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVRYVSDKG 899
            ....|||:.||.||.|:..|.|:|||||||:.|||:|||||||||:||||||||.:||...|:|.
Mouse  1530 RTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKS 1594

  Fly   900 IEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFDLEPEEQ 964
            .|.::|:.||||||.||||||||.|.|:.....|:.:     |:|...|           |.|.|
Mouse  1595 TEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERI-----LKQVSGG-----------EDEIQ 1643

  Fly   965 RTDFLQKILLDFLAVNAQ-EENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKSKIRNNR 1028
            :   |||.|||:|..|.: :.:|:  ::|.||:|||:||...:..:....:|             
Mouse  1644 Q---LQKALLDYLDENTETDPSLV--FSRKFYIAQWFRDTTLETEKAMKSQK------------- 1690

  Fly  1029 RTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPF-SVFGE 1092
                           ||..:|...      .:.:.|....|....|.||::..:.||.. |.|..
Mouse  1691 ---------------DEESSDATH------HAKELETTGQIMHRAENRKKFLRSIIKTTPSQFST 1734

  Fly  1093 QNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIV 1157
            ...:|:.     :||::|.||.:|||:.|||:||||..|.:|:.|:.|.:|||||:|||||:.:|
Mouse  1735 LKMNSDT-----VDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1794

  Fly  1158 EVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVR 1222
            .|||.:|.|.|||.||:.:.:|.:.|||||||:|:|:|||....|.:||||||..||||||:|||
Mouse  1795 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVR 1859

  Fly  1223 KRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKIGIQRKI 1287
            |||||||||||:|.|.|.||.|:||||||||:|||||:|||.|.|.|:||||...|||..:.|||
Mouse  1860 KRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKI 1924

  Fly  1288 NHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIACQQLADGLV 1352
            .:|.|||....|||..|.|.||       .|:|:||       :.:|..|  :..||.||.|.||
Mouse  1925 LNITDVVAACRDTGYDWFEQLL-------QNLLKSE-------EDSSYKP--VKKACTQLVDNLV 1973

  Fly  1353 DRLIELE----DTDN-----SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSATAAKFI 1408
            :.:::.|    |:||     .|::.|||||.|.:|:||||:||||:|::|||..||.:......|
Mouse  1974 EHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVI 2038

  Fly  1409 CAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDC 1473
            |.||.|||.||||:.:.||:|||::||.||.|::......|..|||||||:|||:|.|||.:..|
Mouse  2039 CNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWAC 2103

  Fly  1474 FQKFYRVLDVSRSQVIQGNNSVDNIYT-PSFRRSLFTIGILMRYFDFKSPIALGETNDGLPVSIC 1537
            |.::|..:...:||..:..|:...:.. |:..|||||:|.|.|:|||.    |.:......|:|.
Mouse  2104 FNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFD----LEDFKGNSKVNIK 2164

  Fly  1538 EDVFHCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGFKIICMR 1602
            :.|...||:|.:.:::|::.:|:|.||...:.:...:...|:||||..|||...:....||..::
Mouse  2165 DKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNSILSDKNSSVNLKIQVLK 2229

  Fly  1603 NIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRDDTVRLW 1667
            |:..||.|.:..|...:::|:|.:|.||||||.||||||:|.|:||||:::||.|.:...:||.:
Mouse  2230 NLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHF 2294

  Fly  1668 AVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQLCF 1732
            |:.||.:.|.|||:|||:.|||||.:.||......::||..|.:|||.|:||::||...|:::.:
Mouse  2295 ALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSY 2359

  Fly  1733 KLQKILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDD-QKTS 1796
            ::|:.:   |....:.:||:..   |.:::||...||:::|..:..|||.:.::...||| .||.
Mouse  2360 QVQQAI---NTCLKDPVRGFRQ---DESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTE 2418

  Fly  1797 LQQMLYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHI----------KPSDKEG 1851
            :..:||||||||.|||..|:|||:::|.||:.:|::|::||.:|||.:          .|: ||.
Mouse  2419 VTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKTSPA-KEN 2482

  Fly  1852 DVLEDDDDVEDPEVLFNRL--------PEDLTEIIKCITS-----------AQACMLLLILKDHL 1897
            :..|.:::|..|.....|:        .:|:..::||:..           :|..:|||:||.||
Mouse  2483 ESSESEEEVSRPRKSRKRVDSESDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHL 2547

  Fly  1898 KEMYAITDSKISRYSPSEQ-KLYEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDINFTLTKEE 1961
            |.:...:||||.:|||||. |:|:||:.||:...|:||.|:|.::..|:..||:.|:        
Mouse  2548 KNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKLTEDV-------- 2604

  Fly  1962 KLDLVVKYLDFKQLMLKLDPDDGDSDADES-----RDKTML----------NISASSD------- 2004
            |..:|.:|||||.||..||||:.:.:.:.|     |:|.:.          |.:|.::       
Mouse  2605 KRSIVRQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAADTEDEESDGE 2669

  Fly  2005 --GVAFSSSAKNSHSACDGYSLTV-----TDVVDV 2032
              |...|.|.:.|....|...|..     .||:||
Mouse  2670 DRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDV 2704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nipped-BNP_001036451.1 Cohesin_HEAT 1151..1192 CDD:289531 22/40 (55%)
Nipped-B_C 1643..1826 CDD:289591 74/183 (40%)
NipblNP_081983.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..338 16/209 (8%)
DAZAP2 146..>214 CDD:371348 6/67 (9%)
PTZ00121 <476..1099 CDD:173412 79/629 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..940 56/458 (12%)
PxVxL motif. /evidence=ECO:0000250|UniProtKB:Q6KC79 990..1003 1/12 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1041 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1186 18/137 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1685..1706 4/54 (7%)
HEAT 1 1761..1799 21/37 (57%)
Cohesin_HEAT 1788..1829 CDD:372300 22/40 (55%)
HEAT repeat 1805..1833 CDD:293787 15/27 (56%)
HEAT 2 1837..1875 28/37 (76%)
HEAT repeat 1842..1868 CDD:293787 22/25 (88%)
HEAT 3 1939..1978 17/54 (31%)
HEAT 4 2221..2261 14/39 (36%)
Nipped-B_C 2270..2448 CDD:372337 74/183 (40%)
HEAT 5 2307..2345 18/37 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2467..2514 8/47 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2645..2690 7/44 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847741
Domainoid 1 1.000 420 1.000 Domainoid score I642
eggNOG 1 0.900 - - E1_KOG1020
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H15850
Inparanoid 1 1.050 1086 1.000 Inparanoid score I242
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003400
OrthoInspector 1 1.000 - - oto95116
orthoMCL 1 0.900 - - OOG6_103308
Panther 1 1.100 - - LDO PTHR21704
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R719
SonicParanoid 1 1.000 - - X3855
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.780

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