DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nipped-B and Nipbl

DIOPT Version :9

Sequence 1:	NP_001036451.1	Gene:	Nipped-B / 3355136	FlyBaseID:	FBgn0026401	Length:	2077	Species:	Drosophila melanogaster
Sequence 2:	XP_038959465.1	Gene:	Nipbl / 294787	RGDID:	1306393	Length:	2798	Species:	Rattus norvegicus

Alignment Length:	2851	Identity:	773/2851 - (27%)
Similarity:	1190/2851 - (41%)	Gaps:	965/2851 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNPTVPVTTLAGLTSTSDLLSELPVADSLQSAASLNKSLLFHALVANESSNLLSMRNENLVRQLV 69
            |.|.||:|||||:.|.:|||::||:...|  .|:..|||||::.:|.|.:.||:.|::|||.|||
  Rat     4 DMPHVPITTLAGIASLTDLLNQLPLPSPL--PATTTKSLLFNSRIAEEVNCLLACRDDNLVSQLV 66

  Fly    70 TAIERTNSDNIELIHCPVQDTATNCSTYPELLQGIYHFRPAVF---------------------- 112
            .::.:.::|:|||......|...  ...|.|||.:....|.||
  Rat    67 HSLNQVSTDHIELKDNLGSDDPE--GDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLS 129

  Fly   113 --------------NTSIKIHSPDQH-------TANARLEAKKMQIDS------------YSIPE 144
                          .|:|. |||...       :.|..:..:...:.|            ||.|.
  Rat   130 QNSMHSSPASSNYQQTTIS-HSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPS 193

  Fly   145 CYAS------------------------------------------------------------- 148
            .|.:
  Rat   194 SYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSDDYLHMVHRLSSDD 258

  Fly   149 ----------------------------------------------------PTNLSISNEHQLQ 161
                                                                |.::.:.:..:.|
  Rat   259 GDSSAMRNAASFPLRSPQPVCSPAGSDGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQ 323

  Fly   162 DAQ----------------ACFNQLTSMT--SKEILEEFSQINFKENATEKDKIDVIENSDL--- 205
            ..|                |.::.::|.|  |.::....|::...:...::|.:..:|||::
  Rat   324 KKQKKMKLGKDEKDQNEKAAMYDIISSPTKDSTKLTLRLSRVRSSDMDQQEDMLSGMENSNVSEN 388

  Fly   206 -------------------------------------------NVTKILSQNTLKKKSNTPERST 227
                                                       |...:|.||| ...:..|:.|.
  Rat   389 DIPFNVQYPGQTSKTPITPQDVNRSLNAAQCLSQQEQTAFLPANQVPVLQQNT-SVATKQPQTSV 452

  Fly   228 VQSIQ-------------------------------EQFFIQQQEANYNLKH------------- 248
            ||:.|                               |:|..:.|:.:..||.
  Rat   453 VQNQQQVSQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGA 517

  Fly   249 --------------------------DLNQV---------------------------------- 253
                                      ||:|.
  Rat   518 TGGNRPASQETGSTGNGSRPALMVSIDLHQAGRADSQASLTQDSDNIKKPEETKQCNDAPISVLQ 582

  Fly   254 STNVGQIQNISDTFPQEPSN--------------------------------------------- 273
            ..:||.:::|.:..|:.|.|
  Rat   583 EDSVGSLKSIPENHPETPKNKSDPELSKSEMKQNESRLSESKPNENQLGESKSNESKLETKTETQ 647

  Fly   274 -----------------------------------------FNLNSVN------IPNMLYVQSP- 290
                                                     .|..|.|      .|.......|
  Rat   648 TEELKQSENKTTESKQSESAVVEPKQNENRLCDTKPNDNKQNNTRSENTKARPETPKQKAESRPE 712

  Fly   291 ----------------------------------------------------------PFTESEP 297
                                                                      |.||.:|
  Rat   713 TPKQKSEGRPETPKQKGDGRPETPKQKSEGRPETPKQKGEGRPETPKHRHENRKDSGKPSTEKKP 777

  Fly   298 TQAHH-----SSIEYLKKKKSQIL--------------------------------DVSILNRQQ 325
            ..:.|     |....||.::::.|                                |.|.:.|.:
  Rat   778 DVSKHKQDIKSDSSRLKSERAEALKQRPDGRSESLRRDHDSKQKSDDRGESERHRGDQSRVRRPE 842

  Fly   326 VLENTSLHIINKSST-------------------------------------------------- 340
            .|.::|.   |:.||
  Rat   843 TLRSSSR---NEHSTKSDGSKTEKLERKHRHESGDSRDRPSGEQKSRPDSPRVKQGDTNKSRPGF 904

  Fly   341 --------YQTNQNVSTTTSTSTSSSGKSQVR--------------------------------- 364
                    .:|..|.|...|....:..|::..
  Rat   905 KSPNSKDDKRTEGNRSKVDSNKAHTDNKAEFPSYLLGGRSSALKNFVIPKIKRDKDGNITQETKK 969

  Fly   365 ---------------------------VCINRLSIED-----------SRLMQQSIKKFVQKS-- 389
                                       |.:.:||::|           ||...:|:|....||
  Rat   970 MDMKGEQKDKVEKMGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREEKSRSSLKSLKNKPSKSNK 1034

  Fly   390 ------------PELARSMGLLQETCQQQHENLNIIPTSAEECVLESRASSTNNTVKIPIDTFST 442
                        |||...:......|::...|.....|..|:......:|..:|      |:...
  Rat  1035 GSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN------DSDEA 1093

  Fly   443 IKADEKRSAK-------------------------------------RKLAISIGDI-----PP- 464
            .::..||..|                                     |..:.|..|:     ||
  Rat  1094 FESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHDGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1158

  Fly   465 -EQIFSKPKMRRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNF-DSEDVDE 527
             .::..|.|.:..::.......|...||:..|.|:::|..::::|::.|:|.:...| |.:::.:
  Rat  1159 LSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1223

  Fly   528 TIECISSKLLNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVY------LARNYFAGTEDED 586
            .: .:....||.:.::.||:||...:|.:..:|...::|...:|:.      ...|:...||:|:
  Rat  1224 EL-LLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEE 1287

  Fly   587 EFVDDEVIEKLLNAMDACLLICNIYSTVSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY-- 648
            ....|.::|::..:.||||...||.::.:..:.:. ||.:..:|::|:|.|:.|::|.:||||
  Rat  1288 RLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRL 1352

  Fly   649 ----------TAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPL 703
                      .||..|.:||::::         :.:.|.|..:::.....|.:..:..||.:|.:
  Rat  1353 DPHGGGLLSSKAKRAKCSTHKQRV---------IVMLYNKVCDIVSSLSELLEIQLLTDTTILQV 1408

  Fly   704 STLAIEPFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTN 768
            |::.|.||||:|:..||...::|||.:|  .||:|.|..||.:|.||:.|||:||::||.::|.:
  Rat  1409 SSMGITPFFVENVSELQLCAIKLVTAVF--SRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNS 1471

  Fly   769 NGGN-----IQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQ 828
            :..:     ||||||||||||||...||.|          .::.|:.::..||:   .||:::..
  Rat  1472 SDVDGEPMYIQMVTALVLQLIQCVVHLPSS----------EKDPNSEEDSNKKV---DQDVVITN 1523

  Fly   829 KYDVAVSIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVR 893
            .|:.|:....|||:.||.||.|:..|.|:|||||||:.|||:|||||||||:||||||||.:||.
  Rat  1524 SYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVH 1588

  Fly   894 YVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFD 958
            ..|:|..|.::|:.||||||.||||||||.|.|:.....|:.:     |:|...|
  Rat  1589 QFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERI-----LKQVSGG---------- 1638

  Fly   959 LEPEEQRTDFLQKILLDFLAVNAQ-EENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKS 1022
             |.|.|:   |||.|||:|..|.: :.:|:  ::|.||:|||:||...:..:....:|.
  Rat  1639 -EDEIQQ---LQKALLDYLDENTETDPSLV--FSRKFYIAQWFRDTTLETEKAMKSQKD------ 1691

  Fly  1023 KIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPF 1087
                         :.|..|:....:.:|..:.:|               ..|:||::..:.||..
  Rat  1692 -------------EESSDGAHHAKEIETTGQIMH---------------RAESRKRFLRSIIKTT 1728

  Fly  1088 -SVFGEQNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMK 1151
             |.|.....:|:.     :||::|.||.:|||:.|||:||||..|.:|:.|:.|.:|||||:|||
  Rat  1729 PSQFSTLKMNSDT-----VDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMK 1788

  Fly  1152 CLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILD 1216
            ||:.:|.|||.:|.|.|||.||:.:.:|.:.|||||||:|:|:|||....|.:||||||..||||
  Rat  1789 CLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILD 1853

  Fly  1217 TGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKI 1281
            ||:||||||||||||||:|.|.|.||.|:||||||||:|||||:|||.|.|.|:||||...|||.
  Rat  1854 TGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKE 1918

  Fly  1282 GIQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIACQQ 1346
            .:.|||.:|.|||....|||..|.|.||       .|:|:||       :.:|..|  :..||.|
  Rat  1919 AMTRKILNITDVVAACRDTGYDWFEQLL-------QNLLKSE-------EDSSYKP--VKKACTQ 1967

  Fly  1347 LADGLVDRLIELE----DTDN-----SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSA 1402
            |.|.||:.:::.|    |:||     .|::.|||||.|.:|:||||:||||:|::|||..||.:.
  Rat  1968 LVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQ 2032

  Fly  1403 TAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNF 1467
            .....||.||.|||.||||:.:.||:|||::||.||.|::......|..|||||||:|||:|.||
  Rat  2033 NDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNF 2097

  Fly  1468 KLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYT-PSFRRSLFTIGILMRYFDFKSPIALGETNDG 1531
            |.:..||.::|..:...:||..:..|:...:.. |:..|||||:|.|.|:|||.    |.:....
  Rat  2098 KFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFD----LEDFKGN 2158

  Fly  1532 LPVSICEDVFHCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGF 1596
            ..|:|.:.|...||:|.:.:::|::.:|:|.||...:.:...:...|:||||..|||...:....
  Rat  2159 SKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNSILSDKNSSVNL 2223

  Fly  1597 KIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRD 1661
            ||..::|:..||.|.:..|...:::|:|.:|.||||||.||||||:|.|:||||:::||.|.:..
  Rat  2224 KIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQ 2288

  Fly  1662 DTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQF 1726
            .:||.:|:.||.:.|.|||:|||:.|||||.:.||......::||..|.:|||.|:||::||...
  Rat  2289 SSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVA 2353

  Fly  1727 GLQLCFKLQKILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFD 1791
            |:::.:::|:.:   |....:.:||:..   |.:::||...||:::|..:..|||.:.::...||
  Rat  2354 GMKMSYQVQQAI---NTCLKDPVRGFRQ---DESSSALCSHLYSMIRGNRQHRRAFLISLLNLFD 2412

  Fly  1792 D-QKTSLQQMLYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHI----------- 1844
            | .||.:..:||||||||.|||..|:|||:::|.||:.:|::|::||.:|||.:
  Rat  2413 DTAKTEVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKTS 2477

  Fly  1845 -----------------KPSDKEGDVLEDDDDVEDPEVLFNRLPEDLTEIIKCITSAQACMLLLI 1892
                             :.|.|..|...|.|..:|...:...|||:...:|:....:|..:|||:
  Rat  2478 PAKENESSESEEEVCRPRKSRKRVDSESDSDSEDDVNSVMKCLPENSAPLIEFANVSQGILLLLM 2542

  Fly  1893 LKDHLKEMYAITDSKISRYSPSEQ-KLYEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDINFT 1956
            ||.|||.:...:||||.:|||||. |:|:||:.||:...|:||.|:|.::..|:..||:.|:
  Rat  2543 LKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKLTEDV--- 2604

  Fly  1957 LTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADESRDKTMLNISASSDGVAFSSSAKNSHSACDG 2021
                 |..:|.:|||||.||..||||:.:.:.:                |:.|::|:|
  Rat  2605 -----KRSIVRQYLDFKLLMEHLDPDEEEEEGE----------------VSASTNARN------- 2641

  Fly  2022 YSLTVTDVVDVPMSHIAKASMLTSKPSG--RKTNPVRTKKKRRKIDSTDDETSDAE 2075
                             ||  :||...|  .|.||..         .|:||.||.|
  Rat  2642 -----------------KA--ITSLLGGGSPKNNPAA---------DTEDEESDGE 2669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-B	NP_001036451.1	Cohesin_HEAT	1151..1192	CDD:289531	22/40 (55%)
Nipped-B	NP_001036451.1	Nipped-B_C	1643..1826	CDD:289591	74/183 (40%)
Nipbl	XP_038959465.1	PTZ00121	<559..1110	CDD:173412	56/559 (10%)
		PspC_subgroup_2	<593..830	CDD:411408	17/236 (7%)
		Cohesin_HEAT	1788..1829	CDD:403845	22/40 (55%)
		HEAT repeat	1805..1833	CDD:293787	15/27 (56%)
		HEAT repeat	1838..1872	CDD:410996	27/33 (82%)
		HEAT repeat	1842..1868	CDD:293787	22/25 (88%)
		Nipped-B_C	2271..2447	CDD:403897	73/181 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351313
Domainoid	1	1.000	406	1.000	Domainoid score	I695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15850
Inparanoid	1	1.050	1072	1.000	Inparanoid score	I233
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003400
OrthoInspector	1	1.000	-	-		oto98608
orthoMCL	1	0.900	-	-		OOG6_103308
Panther	1	1.100	-	-	LDO	PTHR21704
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3855
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890