|
Fly 5 DNPTVPVTTLAGLTSTSDLLSELPVADSLQSAASLNKSLLFHALVANESSNLLSMRNENLVRQLV 69
|.|.||:|||||:.|.:|||::||:...| .|:..|||||::.:|.|.:.||:.|::|||.|||
Rat 4 DMPHVPITTLAGIASLTDLLNQLPLPSPL--PATTTKSLLFNSRIAEEVNCLLACRDDNLVSQLV 66
Fly 70 TAIERTNSDNIELIHCPVQDTATNCSTYPELLQGIYHFRPAVF---------------------- 112
.::.:.::|:|||......|... ...|.|||.:....|.||
Rat 67 HSLNQVSTDHIELKDNLGSDDPE--GDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLS 129
Fly 113 --------------NTSIKIHSPDQH-------TANARLEAKKMQIDS------------YSIPE 144
.|:|. |||... :.|..:..:...:.| ||.|.
Rat 130 QNSMHSSPASSNYQQTTIS-HSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPS 193
Fly 145 CYAS------------------------------------------------------------- 148
.|.:
Rat 194 SYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSDDYLHMVHRLSSDD 258
Fly 149 ----------------------------------------------------PTNLSISNEHQLQ 161
|.::.:.:..:.|
Rat 259 GDSSAMRNAASFPLRSPQPVCSPAGSDGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQ 323
Fly 162 DAQ----------------ACFNQLTSMT--SKEILEEFSQINFKENATEKDKIDVIENSDL--- 205
..| |.::.::|.| |.::....|::...:...::|.:..:|||::
Rat 324 KKQKKMKLGKDEKDQNEKAAMYDIISSPTKDSTKLTLRLSRVRSSDMDQQEDMLSGMENSNVSEN 388
Fly 206 -------------------------------------------NVTKILSQNTLKKKSNTPERST 227
|...:|.||| ...:..|:.|.
Rat 389 DIPFNVQYPGQTSKTPITPQDVNRSLNAAQCLSQQEQTAFLPANQVPVLQQNT-SVATKQPQTSV 452
Fly 228 VQSIQ-------------------------------EQFFIQQQEANYNLKH------------- 248
||:.| |:|..:.|:.:..||.
Rat 453 VQNQQQVSQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGA 517
Fly 249 --------------------------DLNQV---------------------------------- 253
||:|.
Rat 518 TGGNRPASQETGSTGNGSRPALMVSIDLHQAGRADSQASLTQDSDNIKKPEETKQCNDAPISVLQ 582
Fly 254 STNVGQIQNISDTFPQEPSN--------------------------------------------- 273
..:||.:::|.:..|:.|.|
Rat 583 EDSVGSLKSIPENHPETPKNKSDPELSKSEMKQNESRLSESKPNENQLGESKSNESKLETKTETQ 647
Fly 274 -----------------------------------------FNLNSVN------IPNMLYVQSP- 290
.|..|.| .|.......|
Rat 648 TEELKQSENKTTESKQSESAVVEPKQNENRLCDTKPNDNKQNNTRSENTKARPETPKQKAESRPE 712
Fly 291 ----------------------------------------------------------PFTESEP 297
|.||.:|
Rat 713 TPKQKSEGRPETPKQKGDGRPETPKQKSEGRPETPKQKGEGRPETPKHRHENRKDSGKPSTEKKP 777
Fly 298 TQAHH-----SSIEYLKKKKSQIL--------------------------------DVSILNRQQ 325
..:.| |....||.::::.| |.|.:.|.:
Rat 778 DVSKHKQDIKSDSSRLKSERAEALKQRPDGRSESLRRDHDSKQKSDDRGESERHRGDQSRVRRPE 842
Fly 326 VLENTSLHIINKSST-------------------------------------------------- 340
.|.::|. |:.||
Rat 843 TLRSSSR---NEHSTKSDGSKTEKLERKHRHESGDSRDRPSGEQKSRPDSPRVKQGDTNKSRPGF 904
Fly 341 --------YQTNQNVSTTTSTSTSSSGKSQVR--------------------------------- 364
.:|..|.|...|....:..|::..
Rat 905 KSPNSKDDKRTEGNRSKVDSNKAHTDNKAEFPSYLLGGRSSALKNFVIPKIKRDKDGNITQETKK 969
Fly 365 ---------------------------VCINRLSIED-----------SRLMQQSIKKFVQKS-- 389
|.:.:||::| ||...:|:|....||
Rat 970 MDMKGEQKDKVEKMGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREEKSRSSLKSLKNKPSKSNK 1034
Fly 390 ------------PELARSMGLLQETCQQQHENLNIIPTSAEECVLESRASSTNNTVKIPIDTFST 442
|||...:......|::...|.....|..|:......:|..:| |:...
Rat 1035 GSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN------DSDEA 1093
Fly 443 IKADEKRSAK-------------------------------------RKLAISIGDI-----PP- 464
.::..||..| |..:.|..|: ||
Rat 1094 FESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHDGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1158
Fly 465 -EQIFSKPKMRRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNF-DSEDVDE 527
.::..|.|.:..::.......|...||:..|.|:::|..::::|::.|:|.:...| |.:::.:
Rat 1159 LSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1223
Fly 528 TIECISSKLLNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVY------LARNYFAGTEDED 586
.: .:....||.:.::.||:||...:|.:..:|...::|...:|:. ...|:...||:|:
Rat 1224 EL-LLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEE 1287
Fly 587 EFVDDEVIEKLLNAMDACLLICNIYSTVSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY-- 648
....|.::|::..:.||||...||.::.:..:.:. ||.:..:|::|:|.|:.|::|.:||||
Rat 1288 RLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRL 1352
Fly 649 ----------TAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPL 703
.||..|.:||:::: :.:.|.|..:::.....|.:..:..||.:|.:
Rat 1353 DPHGGGLLSSKAKRAKCSTHKQRV---------IVMLYNKVCDIVSSLSELLEIQLLTDTTILQV 1408
Fly 704 STLAIEPFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTN 768
|::.|.||||:|:..||...::|||.:| .||:|.|..||.:|.||:.|||:||::||.::|.:
Rat 1409 SSMGITPFFVENVSELQLCAIKLVTAVF--SRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNS 1471
Fly 769 NGGN-----IQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQ 828
:..: ||||||||||||||...||.| .::.|:.::..||: .||:::..
Rat 1472 SDVDGEPMYIQMVTALVLQLIQCVVHLPSS----------EKDPNSEEDSNKKV---DQDVVITN 1523
Fly 829 KYDVAVSIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVR 893
.|:.|:....|||:.||.||.|:..|.|:|||||||:.|||:|||||||||:||||||||.:||.
Rat 1524 SYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVH 1588
Fly 894 YVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFD 958
..|:|..|.::|:.||||||.||||||||.|.|:.....|:.: |:|...|
Rat 1589 QFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERI-----LKQVSGG---------- 1638
Fly 959 LEPEEQRTDFLQKILLDFLAVNAQ-EENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKS 1022
|.|.|: |||.|||:|..|.: :.:|: ::|.||:|||:||...:..:....:|.
Rat 1639 -EDEIQQ---LQKALLDYLDENTETDPSLV--FSRKFYIAQWFRDTTLETEKAMKSQKD------ 1691
Fly 1023 KIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPF 1087
:.|..|:....:.:|..:.:| ..|:||::..:.||..
Rat 1692 -------------EESSDGAHHAKEIETTGQIMH---------------RAESRKRFLRSIIKTT 1728
Fly 1088 -SVFGEQNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMK 1151
|.|.....:|:. :||::|.||.:|||:.|||:||||..|.:|:.|:.|.:|||||:|||
Rat 1729 PSQFSTLKMNSDT-----VDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMK 1788
Fly 1152 CLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILD 1216
||:.:|.|||.:|.|.|||.||:.:.:|.:.|||||||:|:|:|||....|.:||||||..||||
Rat 1789 CLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILD 1853
Fly 1217 TGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKI 1281
||:||||||||||||||:|.|.|.||.|:||||||||:|||||:|||.|.|.|:||||...|||.
Rat 1854 TGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKE 1918
Fly 1282 GIQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIACQQ 1346
.:.|||.:|.|||....|||..|.|.|| .|:|:|| :.:|..| :..||.|
Rat 1919 AMTRKILNITDVVAACRDTGYDWFEQLL-------QNLLKSE-------EDSSYKP--VKKACTQ 1967
Fly 1347 LADGLVDRLIELE----DTDN-----SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSA 1402
|.|.||:.:::.| |:|| .|::.|||||.|.:|:||||:||||:|::|||..||.:.
Rat 1968 LVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQ 2032
Fly 1403 TAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNF 1467
.....||.||.|||.||||:.:.||:|||::||.||.|::......|..|||||||:|||:|.||
Rat 2033 NDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNF 2097
Fly 1468 KLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYT-PSFRRSLFTIGILMRYFDFKSPIALGETNDG 1531
|.:..||.::|..:...:||..:..|:...:.. |:..|||||:|.|.|:|||. |.:....
Rat 2098 KFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFD----LEDFKGN 2158
Fly 1532 LPVSICEDVFHCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGF 1596
..|:|.:.|...||:|.:.:::|::.:|:|.||...:.:...:...|:||||..|||...:....
Rat 2159 SKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNSILSDKNSSVNL 2223
Fly 1597 KIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRD 1661
||..::|:..||.|.:..|...:::|:|.:|.||||||.||||||:|.|:||||:::||.|.:..
Rat 2224 KIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQ 2288
Fly 1662 DTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQF 1726
.:||.:|:.||.:.|.|||:|||:.|||||.:.||......::||..|.:|||.|:||::||...
Rat 2289 SSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVA 2353
Fly 1727 GLQLCFKLQKILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFD 1791
|:::.:::|:.: |....:.:||:.. |.:::||...||:::|..:..|||.:.::...||
Rat 2354 GMKMSYQVQQAI---NTCLKDPVRGFRQ---DESSSALCSHLYSMIRGNRQHRRAFLISLLNLFD 2412
Fly 1792 D-QKTSLQQMLYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHI----------- 1844
| .||.:..:||||||||.|||..|:|||:::|.||:.:|::|::||.:|||.:
Rat 2413 DTAKTEVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKTS 2477
Fly 1845 -----------------KPSDKEGDVLEDDDDVEDPEVLFNRLPEDLTEIIKCITSAQACMLLLI 1892
:.|.|..|...|.|..:|...:...|||:...:|:....:|..:|||:
Rat 2478 PAKENESSESEEEVCRPRKSRKRVDSESDSDSEDDVNSVMKCLPENSAPLIEFANVSQGILLLLM 2542
Fly 1893 LKDHLKEMYAITDSKISRYSPSEQ-KLYEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDINFT 1956
||.|||.:...:||||.:|||||. |:|:||:.||:...|:||.|:|.::..|:..||:.|:
Rat 2543 LKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKLTEDV--- 2604
Fly 1957 LTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADESRDKTMLNISASSDGVAFSSSAKNSHSACDG 2021
|..:|.:|||||.||..||||:.:.:.: |:.|::|:|
Rat 2605 -----KRSIVRQYLDFKLLMEHLDPDEEEEEGE----------------VSASTNARN------- 2641
Fly 2022 YSLTVTDVVDVPMSHIAKASMLTSKPSG--RKTNPVRTKKKRRKIDSTDDETSDAE 2075
|| :||...| .|.||.. .|:||.||.|
Rat 2642 -----------------KA--ITSLLGGGSPKNNPAA---------DTEDEESDGE 2669
| 
