DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nipped-B and NIPBL

DIOPT Version :9

Sequence 1:	NP_001036451.1	Gene:	Nipped-B / 3355136	FlyBaseID:	FBgn0026401	Length:	2077	Species:	Drosophila melanogaster
Sequence 2:	NP_597677.2	Gene:	NIPBL / 25836	HGNCID:	28862	Length:	2804	Species:	Homo sapiens

Alignment Length:	2837	Identity:	769/2837 - (27%)
Similarity:	1196/2837 - (42%)	Gaps:	939/2837 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DNPTVPVTTLAGLTSTSDLLSELPVADSLQSAASLNKSLLFHALVANESSNLLSMRNENLVRQLV 69
            |.|.||:|||||:.|.:|||::||:...|  .|:..|||||:|.:|.|.:.||:.|::|||.|||
Human     4 DMPHVPITTLAGIASLTDLLNQLPLPSPL--PATTTKSLLFNARIAEEVNCLLACRDDNLVSQLV 66

  Fly    70 TAIERTNSDNIEL---------------------------------------------------- 82
            .::.:.::|:|||
Human    67 HSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQN 131

  Fly    83 -IH---------------------CPVQDTATN------------------------------CS 95
             :|                     .|.|.::.|                              .:
Human   132 SMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYT 196

  Fly    96 TYPELLQ----------GIYHFRPAVFNTSIKIHSPDQHTANARLEAKK---------------- 134
            |:|::.|          |:.:......:..:..:|.:.|..|.|..:.:
Human   197 THPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDS 261

  Fly   135 ---------------------------------MQIDSYSIPECYASPTN--------------- 151
                                             :.:.|.|:| | :||.:
Human   262 STMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLP-C-SSPRDVPPDILLDSPERKQK 324

  Fly   152 ----LSISNEHQLQDAQACFNQLTSMTSKE---ILEEFSQINFKENATEKDKIDVIENSDL---- 205
                :.:..:.:.|..:|....:.|..||:   :....|::...:...::|.|..:|||::
Human   325 KQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSEND 389

  Fly   206 ------------------------------------------NVTKILSQNTLKKKSNTPERSTV 228
                                                      |...:|.||| ...:..|:.|.|
Human   390 IPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNT-SVAAKQPQTSVV 453

  Fly   229 QSIQ-------------------------------EQFFIQQQEANYNLK--------------- 247
            |:.|                               |:|..:.|:.:..||
Human   454 QNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGAT 518

  Fly   248 ---------------------------HDLNQVSTN----------------------------- 256
                                       |...:|.:.
Human   519 GGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE 583

  Fly   257 --VGQIQNISDTFPQEP------------------------------------------------ 271
              ||.:::..:..|:.|
Human   584 DIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648

  Fly   272 ------------------------SNFNLNSVNIPNML--------------------------- 285
                                    .|.|..|...||..
Human   649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPET 713

  Fly   286 -------YVQSP---------------------------------------------PFTESEPT 298
                   :.::|                                             |.||.:|.
Human   714 PKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPE 778

  Fly   299 QAHH-----SSIEYLKKKKSQIL----------------------------------DVSILNRQ 324
            .:.|     |....||.::::.|                                  |.|.:.|.
Human   779 VSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRP 843

  Fly   325 QVLENTSL--HII--------------------------------------------NKSSTYQT 343
            :.|.::|.  |.|                                            |||.:.:.
Human   844 ETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKL 908

  Fly   344 NQNVSTTTSTSTSSSGKSQVR-------------------------------------------- 364
            .....|:.....:...||:|.
Human   909 GFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973

  Fly   365 -----------------------------VCINRLSIED-----------SRLMQQSIKKFVQKS 389
                                         |.:.:||::|           ||...:.||....||
Human   974 KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKS 1038

  Fly   390 --------------PELARSMGLLQETCQQQHENLNIIPTSAEECVLESRASSTNNTVKIPIDTF 440
                          |||...:......|::...|.....|..|:......:|..:|      |:.
Human  1039 NKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN------DSD 1097

  Fly   441 STIKADEKRSAK-------------------------------------RKLAISIGDI-----P 463
            ...::..||..|                                     |..:.|..|:     |
Human  1098 EAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPP 1162

  Fly   464 P--EQIFSKPKMRRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNF-DSEDV 525
            |  .::..|.|.:..::.......|...||:..|.|:::|..::::|::.|:|.:...| |.:::
Human  1163 PSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEI 1227

  Fly   526 DETIECISSKLLNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVY------LARNYFAGTED 584
            .:.: .:....||.:.::.||:||...:|.:..:|...::|...:|:.      ...|:...||:
Human  1228 PQEL-LLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEE 1291

  Fly   585 EDEFVDDEVIEKLLNAMDACLLICNIYSTVSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY 648
            |:....|.::|::..:.||||...||.::.:..:.:. ||.:..:|::|:|.|:.|::|.:||||
Human  1292 EERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVY 1356

  Fly   649 ------------TAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVL 701
                        .||..|.:||::::         :.:.|.|..:::.....|.:..:..||.:|
Human  1357 RLDPHGGGLLSSKAKRAKCSTHKQRV---------IVMLYNKVCDIVSSLSELLEIQLLTDTTIL 1412

  Fly   702 PLSTLAIEPFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKL 766
            .:|::.|.||||:|:..||...::|||.:|  .||:|.|..||.:|.||:.|||:||::||.::|
Human  1413 QVSSMGITPFFVENVSELQLCAIKLVTAVF--SRYEKHRQLILEEIFTSLARLPTSKRSLRNFRL 1475

  Fly   767 TNNGGN-----IQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLV 826
            .::..:     ||||||||||||||...||.|          .::.|..::..||:   .||:::
Human  1476 NSSDMDGEPMYIQMVTALVLQLIQCVVHLPSS----------EKDSNAEEDSNKKI---DQDVVI 1527

  Fly   827 LQKYDVAVSIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTML 891
            ...|:.|:....|||:.||.||.|:..|.|:|||||||:.|||:|||||||||:||||||||.:|
Human  1528 TNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLL 1592

  Fly   892 VRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQ 956
            |...|:|..|.::|:.||||||.||||||||.|.|:.....|:.:     |:|...|
Human  1593 VHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERI-----LKQVSGG-------- 1644

  Fly   957 FDLEPEEQRTDFLQKILLDFLAVNAQ-EENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFR 1020
               |.|.|:   |||.|||:|..|.: :.:|:  ::|.||:|||:||...:..:....:|.
Human  1645 ---EDEIQQ---LQKALLDYLDENTETDPSLV--FSRKFYIAQWFRDTTLETEKAMKSQKD---- 1697

  Fly  1021 KSKIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIK 1085
                           :.|..|:....:.:|..:.:|               ..|.||::..:.||
Human  1698 ---------------EESSEGTHHAKEIETTGQIMH---------------RAENRKKFLRSIIK 1732

  Fly  1086 PF-SVFGEQNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRA 1149
            .. |.|.....:|:.     :||::|.||.:|||:.|||:||||..|.:|:.|:.|.:|||||:|
Human  1733 TTPSQFSTLKMNSDT-----VDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKA 1792

  Fly  1150 MKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRI 1214
            ||||:.:|.|||.:|.|.|||.||:.:.:|.:.|||||||:|:|:|||....|.:||||||..||
Human  1793 MKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERI 1857

  Fly  1215 LDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKND 1279
            ||||:||||||||||||||:|.|.|.||.|:||||||||:|||||:|||.|.|.|:||||...||
Human  1858 LDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHND 1922

  Fly  1280 KIGIQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIAC 1344
            |..:.|||.:|.|||....|||..|.|.||       .|:|:||       :.:|..|  :..||
Human  1923 KEAMTRKILNITDVVAACRDTGYDWFEQLL-------QNLLKSE-------EDSSYKP--VKKAC 1971

  Fly  1345 QQLADGLVDRLIELE----DTDN-----SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCH 1400
            .||.|.||:.:::.|    |:||     .|::.|||||.|.:|:||||:||||:|::|||..||.
Human  1972 TQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCS 2036

  Fly  1401 SATAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITH 1465
            :......||.||.|||.||||:.:.||:|||::||.||.|::......|..|||||||:|||:|.
Human  2037 TQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQ 2101

  Fly  1466 NFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYT-PSFRRSLFTIGILMRYFDFKSPIALGETN 1529
            |||.:..||.::|..:...:||..:..|:...:.. |:..|||||:|.|.|:|||.    |.:..
Human  2102 NFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFD----LEDFK 2162

  Fly  1530 DGLPVSICEDVFHCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDA 1594
            ....|:|.:.|...||:|.:.:::|::.:|:|.||...:.:...:...|:||||..|||...:..
Human  2163 GNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSV 2227

  Fly  1595 GFKIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLN 1659
            ..||..::|:..||.|.:..|...:::|:|.:|.||||||.||||||:|.|:||||:::||.|.:
Human  2228 NLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFH 2292

  Fly  1660 RDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKV 1724
            ...:||.:|:.||.:.|.|||:|||:.|||||.:.||......::||..|.:|||.|:||::||.
Human  2293 TQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKA 2357

  Fly  1725 QFGLQLCFKLQKILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQ 1789
            ..|:::.:::|:.:   |....:.:||:..   |.:::||...||:::|..:..|||.:.::...
Human  2358 VAGMKMSYQVQQAI---NTCLKDPVRGFRQ---DESSSALCSHLYSMIRGNRQHRRAFLISLLNL 2416

  Fly  1790 FDD-QKTSLQQMLYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHI--------- 1844
            ||| .||.:..:||||||||.|||..|:|||:::|.||:.:|::|::||.:|||.:
Human  2417 FDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERK 2481

  Fly  1845 -------KPSDKEGDVL------------EDDDDVEDPEVLFNRLPEDLTEIIKCITSAQACMLL 1890
                   :.||.|.:|.            .|.|..:|...:...|||:...:|:....:|..:||
Human  2482 SSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLL 2546

  Fly  1891 LILKDHLKEMYAITDSKISRYSPSEQ-KLYEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDIN 1954
            |:||.|||.:...:||||.:|||||. |:|:||:.||:...|:||.|:|.::..|:..|
Human  2547 LMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSK------ 2605

  Fly  1955 FTLTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADES-----RDKTML----------NISASSD 2004
              :|:|.|..:|.:|||||.||..||||:.:.:.:.|     |:|.:.          |.:|.::
Human  2606 --ITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETE 2668

  Fly  2005 ---------GVAFSSSAKNSHSACDGYSLTV-----TDVVDV 2032
                     |...|.|.:.|....|...|..     .||:||
Human  2669 DDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDV 2710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipped-B	NP_001036451.1	Cohesin_HEAT	1151..1192	CDD:289531	22/40 (55%)
Nipped-B	NP_001036451.1	Nipped-B_C	1643..1826	CDD:289591	74/183 (40%)
NIPBL	NP_597677.2	DUF1421	<113..307	CDD:284607	16/195 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..340		19/213 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..946		40/463 (9%)
		PxVxL motif. /evidence=ECO:0000269\|PubMed:20562864, ECO:0000269\|PubMed:28167679	996..1009		1/12 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1047		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1191		18/136 (13%)
		DUF1777	1103..>1160	CDD:285811	6/56 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1691..1710		3/37 (8%)
		HEAT 1	1767..1805		21/37 (57%)
		Cohesin_HEAT	1794..1835	CDD:289531	22/40 (55%)
		HEAT repeat	1811..1839	CDD:293787	15/27 (56%)
		HEAT 2	1843..1881		28/37 (76%)
		HEAT repeat	1848..1874	CDD:293787	22/25 (88%)
		HEAT 3	1945..1984		17/54 (31%)
		HEAT 4	2227..2267		14/39 (36%)
		Nipped-B_C	2276..2454	CDD:289591	74/183 (40%)
		HEAT 5	2313..2351		18/37 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2520		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2651..2696		7/44 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157345
Domainoid	1	1.000	420	1.000	Domainoid score	I638
eggNOG	1	0.900	-	-		E1_KOG1020
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15850
Inparanoid	1	1.050	1082	1.000	Inparanoid score	I243
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003400
OrthoInspector	1	1.000	-	-		oto91535
orthoMCL	1	0.900	-	-		OOG6_103308
Panther	1	1.100	-	-	LDO	PTHR21704
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R719
SonicParanoid	1	1.000	-	-		X3855
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.780