DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nipped-B and scc-2

DIOPT Version :9

Sequence 1:NP_001036451.1 Gene:Nipped-B / 3355136 FlyBaseID:FBgn0026401 Length:2077 Species:Drosophila melanogaster
Sequence 2:NP_001364775.1 Gene:scc-2 / 173410 WormBaseID:WBGene00004166 Length:2176 Species:Caenorhabditis elegans


Alignment Length:2152 Identity:572/2152 - (26%)
Similarity:970/2152 - (45%) Gaps:415/2152 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 EAKKMQIDSYSIPECYASPTNLSISNEHQLQDAQACFNQLTSMTSKEIL--EEFSQI--NFKENA 191
            :.::.|..:..||: :..|.:.|...:.|:|.|.:.....:.::|.:.|  |:..||  ..||..
 Worm   140 QIQRQQPIAQPIPQ-HTIPPSTSNQFQQQIQSAASSIFDSSVISSHQKLYEEQCRQIEKERKEQE 203

  Fly   192 TEKDKIDVIE----NSDLNVTKILSQNTL----KKKSNTPERSTVQSI----------------- 231
            ..|.|.::.|    |.:|...:|..:..|    ::.....||..:..|                 
 Worm   204 ERKRKQELEEQRKRNEELKRLRIAEEKRLLEEQQRLREQMERERLAEIKRLEEAARLEDERRIAA 268

  Fly   232 ----QEQFFIQQQEANYNLKH----------------DLNQVSTNVGQ--IQNISD--TFPQE-- 270
                |:|..:|:.:|..| ||                .::|..|.||.  :.|..|  .||.|  
 Worm   269 DIEAQKQAMLQKMQAEQN-KHIAEVERQRSELEERFARVSQPMTLVGTHFLPNFLDMIPFPYESM 332

  Fly   271 -----PSNFN----------------------LNSVNI----------------PNMLYVQS-PP 291
                 |..|:                      ||:.||                .|.|::.. ||
 Worm   333 VDSTLPQVFDMERDSAILESCDPQMVATISNILNATNIDDIITRMDKLRPDDKETNDLFLDKLPP 397

  Fly   292 FTESEPTQAHHSSIEYLKKKKSQILDVSILNRQQVLENTSLHII----------NKSSTYQT--- 343
            .            |:.:....:..|||...|..::|||..:.:.          ..||:|..   
 Worm   398 I------------IQAVVNYNTSALDVDSHNDMELLENEDVMMTEDITRTTAPSTSSSSYNNHHQ 450

  Fly   344 NQNVSTTTSTSTSSSGKSQVRVCINR----------LSIEDSRLMQQSIKKFVQKSPELARSMGL 398
            |..|..|:|:.:.|.......|.:|.          :|||..|.|..     |.|:|:.....|.
 Worm   451 NSIVMMTSSSVSMSEATQSSSVTMNHHDVDEEGPAPISIEKRRQMMS-----VGKAPKAGGGGGQ 510

  Fly   399 LQETCQQQHENL------NIIPTSA--------------EECVLE---SRASSTNNTVKIP--ID 438
            .|...:...|||      |.:||..              |:.:|:   .........||:|  :.
 Worm   511 NQRKKRDMVENLYDSLTDNFVPTDTGRRGRRRGRGSDDDEDELLQRDLKLIEEMEKGVKLPASVT 575

  Fly   439 TFSTIKAD--------EKRSAKRKLAISIGDIPPEQIFSKP---------KMRRVE--RITPLSN 484
            .|:|.:.|        :||..:.::.......|.:.|.|:.         ||.|.:  :....|.
 Worm   576 GFTTTEEDVQHFFGSQKKRRKEDRIRKDRSPTPEDVIESRDAEWQERLRLKMEREKSRKADEESQ 640

  Fly   485 TKCVKEEVTRSQTYQQFIRNMDHIIEILD--DSE-------------------SPNFDSEDVDET 528
            .....:.:..::|:.:|.:.:|.::|..|  |:|                   ..|.|..|.:|.
 Worm   641 NAWSLQALADNETFTRFCQTVDGVLEQGDSLDTELKMPKNKKRRSGGDHHHKGDENSDESDEEEE 705

  Fly   529 IECISSKL------LNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVYLARNYFAGTE---- 583
            ::.|...|      |..:....|:|:...||.::..:||..|:....||:   |:..:...    
 Worm   706 MDEIDPDLRIELYILEELRRGSARLRENHALQAVGADKLLKLVAMLDRNI---RDAISADNQRLL 767

  Fly   584 ---DEDEFVDDEVIEK------LLNAMDACLLICNIYST-VSDLQFLQEDNVSHIIKFTQFQLRE 638
               |:|..|.| |:||      :..|.||.::..||.|: ....|.:.||.:...:..|:..|..
 Worm   768 VPCDDDVDVGD-VLEKEICEERVKRASDAAVVALNIMSSHRMHKQVIIEDVIDRCVGLTRLLLIH 831

  Fly   639 TIFPLHDPVYTAKSIKR------TTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVD 697
            .|:|..|.:|.:.:.|:      ...|:|......:::..:..|.:..|.:.:...|.......|
 Worm   832 LIYPASDSIYKSVNSKKKDRAPEEARRRKKAGVCTRDKFSEYIYERITEAIGLLAVLVKSESMTD 896

  Fly   698 TIVLPLSTLAIEPFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPS-SKKNL 761
            |.|..::::|:.||||.|:.:||...:.|.:.||.:.. |.:|.|::.|:|:|:.|.|. ::|| 
 Worm   897 TSVHNVASVALTPFFVANVGSLQITAMLLASNIFSRAE-DSLRFSMITDLLSSLHRAPQFTQKN- 959

  Fly   762 RPYKLTNNGGN------IQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQP 820
                 :|||.:      |...|||.:||:|....:|       ||.....|    ||..|:  ..
 Worm   960 -----SNNGYSLPDGSWISTTTALFIQLVQSTIKIP-------KFKKHADE----DELAKR--SK 1006

  Fly   821 SQDLLVLQKYDVAVSIGGNFLTTFLNKCKSRSN----ETDFRPLFENFIHDLLATVNKPEWPASE 881
            .::.:|.:.:..|..:...||..||.||..:.|    |.|:|.||.||:.:||:.:..|||||:|
 Worm  1007 KEEAMVKEGFLKASKVTNAFLNGFLAKCSQKGNKMDGEEDYRILFSNFLQELLSALYSPEWPAAE 1071

  Fly   882 LLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMI-QSIKLEQE 945
            ::|:.||::||:....|..:.:||..||||||.:.|:||||..|:......:|::: :|..|..:
 Worm  1072 MILTALGSLLVKNFRSKSSDMTIRQASLDYLGNITAKLRKDQKEAIAGERRLDAVVKKSFLLLSD 1136

  Fly   946 KEGDVTSNNDQFDLEPEEQRTDFLQKILLDFLAVNAQEENLIWDYARHFYLAQWYRDVIYQRRRI 1010
            |..:...:.|..:|: :..:...|:..|:|:|.:....:.::  ||.:||:.:||::|       
 Worm  1137 KGVEDYESVDISNLK-QNDKLKVLETSLIDYLVITNSSDIIV--YACNFYVGEWYKEV------- 1191

  Fly  1011 NDGKKGLAFRKSKIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALE- 1074
               .:.|...:||::..       :||::|    |.|....:::...:.....|:.:.:.|.|: 
 Worm  1192 ---AEDLESARSKLKQT-------VDTNES----EKDVKKAERKYEKIQYRGAEMKVFLSKILDK 1242

  Fly  1075 ---ARKQYFINKIKPFSVFGEQNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIIL 1136
               .|:....||:|...                   ::|....::||..|.|:.|||..||.|:.
 Worm  1243 KEIKRRLEKSNKVKMLD-------------------SDAFWAVKFLAQSREFTHSFDTYLKHIVF 1288

  Fly  1137 -VVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQ 1200
             ..:|..:|:|::|:|||::|:|.|..||..:|:|..|:.:.:|:...|||:||:|:|:|||.::
 Worm  1289 GAGSETIVALRSKALKCLSSIIEADSSVLILEDVQQAVHTRMVDSHAQVRESAVELIGRFVLYDE 1353

  Fly  1201 DLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTE 1265
            :.:.:||..::.|||||||:||||||:|:|:||.::|.|..||::..:|||||.||||::|||.|
 Worm  1354 EYVRKYYSQIAERILDTGVAVRKRVIRIMREICEKFPTFEMIPDMLARMIRRVTDEEGVKKLVFE 1418

  Fly  1266 VFMKMWFTPC-TKNDKIGIQRKINHIIDVV-NTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQE 1328
            .|..:||.|. |:.....:..|:..:..|. :...|..:.:||.|::.|.               
 Worm  1419 TFTTLWFQPVDTRIYTNAVATKVTTMCSVAQHCIKDAMSDYLEQLILHIV--------------- 1468

  Fly  1329 FIKKNSEPPMDIVIACQQLADGLVDRLIELEDTDNS----------------RMLGCITTLHLLA 1377
               ||.:....:.:|.:|:.|.|||.::.||...:|                :.:..::||.:.:
 Worm  1469 ---KNGQEGSGMSVAVKQIIDSLVDHILNLEQHKSSENVSEVELMRRKEQEEKYMAYLSTLAVFS 1530

  Fly  1378 KVRPQLLVKHAITIEPYLNIKCHSATAAKFIC-AVADILEKVVPLVNNASESFLASLEEHLMLLV 1441
            |:||.||..|...:.|||........|...:. .:..:||:|:|||...|...|.|::|:|..::
 Worm  1531 KIRPLLLTSHVEVLLPYLTFSGAKTNAENQVTKEMIGMLERVIPLVPFPSNIVLDSIDENLCKVI 1595

  Fly  1442 VSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDV-SRSQVIQGNNSVDNIYTPSFRR 1505
            :....|.|.|.|||:.::..|.........|.|..:.:.|:| .|:........:|....|...|
 Worm  1596 MFNGMALVVSAVSCVASIYKKFKRGATKTIDVFSTYLKHLEVIKRNFDSNPRYDLDPKLFPILSR 1660

  Fly  1506 SLFTIGILMRYFDFKSPIALGETNDGLPVSICEDVFHCLMFFCRCTNQEIRKQALISLGSFCVLN 1570
            |:||:|:|.|||.|:..:....|.:.:. ::.|.||..|.||.|.....:|::||.::|.||..:
 Worm  1661 SIFTLGVLSRYFQFEEFVKEDPTEEKVE-ALKEKVFITLEFFSRYHKGGLRQKALTAMGHFCAQH 1724

  Fly  1571 DGYLTRSELKNLYCEILSSIAN---DAGFKIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLK 1632
            ..|||:.:|.|.|.|||:: ||   ....:|:.::|:.::|...|..:.....:|::..:.::||
 Worm  1725 STYLTKRQLTNTYLEILNA-ANSPQQQQQRILVLQNLEMFLQCEEQKLAASHDKWDENKEAQNLK 1788

  Fly  1633 EMNDVSSGMASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDH 1697
            ||....||:.|.:||.|.:.:||.:::.|..:|..||:|:.:.|.||||.|...:|.||.::||.
 Worm  1789 EMELSGSGLGSSVIQKYWKAVLESYVDADIQLRRAAVQVVWLTLNQGLVTPGASIPTLIAMTTDP 1853

  Fly  1698 RIESAHRADALLKDIDKTYSGFVNMKVQFGLQLCFKLQKILQINNRGKLEIIRGY---------- 1752
            .....:|.|.|||:||..|||.|..|...|::|.:||...|::..:.|  .:||:          
 Worm  1854 VDVIRNRIDILLKEIDSKYSGMVQSKAMQGVRLSYKLHLKLRMLQQEK--FVRGFRFCDFHLNTL 1916

  Fly  1753 ASRGPDNT--TTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQ----KTSLQQMLYIADNLAYFP 1811
            .:..|:.|  ..|:...||..|||.:.|||:.:|::.|.|.::    |..|.:.::||||||.||
 Worm  1917 PNALPEKTHDGMAVLSGLYQSLRTNRQQRRSFLQSMVKLFSEEFSHDKPQLMEYIFIADNLAMFP 1981

  Fly  1812 YVVQDEPLYLIHQIDLLISMAGTHLLATFKEHIKPSDKEGDVLEDDDDVEDPEVLFNRLPE--DL 1874
            |.:.|||||::.|||..|:..|..||..:|..::..:.     ||:|.|...|.:.:||.:  .:
 Worm  1982 YQMIDEPLYVMRQIDQNIAQTGQSLLVQYKLQLRMQES-----EDEDIVFLDENMMSRLSQLGQI 2041

  Fly  1875 TEIIKCITSAQACMLLLILKDHLKEMYAITDSKISRYSPSE-QKLYEKAVTRKSVNDFNPKTTID 1938
            ....:....:|...|||.::..|.::|...::|::.|.||| .|:|||||||::::.|.|.|.::
 Worm  2042 ETFHQLFLDSQVPSLLLYVRTFLMQLYGFNETKVAEYQPSEAAKVYEKAVTRRNIHMFKPITALE 2106

  Fly  1939 VIKKQMSQEKLSTDINFTL---TKEEKLDLVVKYLDFKQLMLKLDP--------------DDGDS 1986
            .             :||..   :.:....|..|...|::::|.||.              ||.|.
 Worm  2107 A-------------LNFPFEWGSFQHTAFLAEKICSFRKMLLSLDQVEEVEVSNTITAANDDYDE 2158

  Fly  1987 DADESRD 1993
            :.|...|
 Worm  2159 EEDGGED 2165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nipped-BNP_001036451.1 Cohesin_HEAT 1151..1192 CDD:289531 17/40 (43%)
Nipped-B_C 1643..1826 CDD:289591 73/198 (37%)
scc-2NP_001364775.1 DUF5401 <185..>302 CDD:375164 23/117 (20%)
Cohesin_HEAT 1304..1345 CDD:403845 17/40 (43%)
HEAT repeat 1315..1351 CDD:410996 15/35 (43%)
HEAT repeat 1321..1351 CDD:293787 13/29 (45%)
HEAT repeat 1359..1385 CDD:410996 17/25 (68%)
HEAT repeat 1362..1384 CDD:293787 14/21 (67%)
HEAT repeat 1395..1423 CDD:293787 16/27 (59%)
Nipped-B_C 1800..1995 CDD:403897 71/196 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160165434
Domainoid 1 1.000 222 1.000 Domainoid score I1485
eggNOG 1 0.900 - - E1_KOG1020
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 616 1.000 Inparanoid score I487
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55220
OrthoDB 1 1.010 - - D608077at2759
OrthoFinder 1 1.000 - - FOG0003400
OrthoInspector 1 1.000 - - oto18595
orthoMCL 1 0.900 - - OOG6_103308
Panther 1 1.100 - - LDO PTHR21704
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R719
SonicParanoid 1 1.000 - - X3855
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.800

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