DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nipped-B and nipbl

DIOPT Version :10

Sequence 1:NP_001036451.1 Gene:Nipped-B / 3355136 FlyBaseID:FBgn0026401 Length:2077 Species:Drosophila melanogaster
Sequence 2:XP_012823388.2 Gene:nipbl / 100038237 XenbaseID:XB-GENE-853274 Length:2938 Species:Xenopus tropicalis


Alignment Length:2114 Identity:712/2114 - (33%)
Similarity:1100/2114 - (52%) Gaps:336/2114 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 TSIKIHSPDQHTANARLEAKKMQIDSYSIPEC--------YASPTNLSISNEHQLQDAQACFNQL 170
            |..|..|| :....:|.:..|.::|.....|.        ...|.:...|.:|:        .::
 Frog   913 TDSKCDSP-RVKPESRTDGAKQRVDGRPSHESSKRDRENPKQKPDDKGESEKHK--------GEM 968

  Fly   171 TSMTSKEILEEFSQINFKE----NATEKDKIDVIE-----NSDLNVTKILSQNTLKKKS------ 220
            :.:...|.|..|:: |.:|    |.::..|||.:|     :||.:..|..|....::.|      
 Frog   969 SRLRRPESLRSFNK-NEQETRPGNKSDAPKIDKVEKKHRHDSDESREKHSSGEQKQRPSSPRIKQ 1032

  Fly   221 ---NTPERSTVQSIQEQFFIQQQEANYNLKH---DLNQVSTNVGQIQNISDTFPQEPSNFNLNSV 279
               :.|.:|....::....:.:.....:.|.   :.::|..|.|...| ...||......|..:.
 Frog  1033 DSKSDPSKSDPTKLKSDKPVLKSPTGKDEKRIDGNKSKVEGNKGHSDN-KTAFPSYLLGGNQGTF 1096

  Fly   280 N---IPNMLYVQSPPFTESEPTQAHHSSIEYLKKKKSQILDVSILNRQQ----VLENTSLHIINK 337
            .   ||.:...:....|: ||.::.....:..|.:|..|  |..||:..    ||:..||..:.|
 Frog  1097 KNFVIPKLKRDKDGNVTQ-EPRRSEPKGEQKDKPEKMGI--VEDLNKGAKPVVVLQKLSLDEVQK 1158

  Fly   338 SSTYQTNQNVSTTTSTSTSSSGKSQVRVCINRLSIEDSRLMQQSIKKFVQKSPELARSMGLLQET 402
            ....:.:::..:..|..             ||.|......:.||:.|  :..|||...:......
 Frog  1159 LIKERDDKSKGSLKSNK-------------NRPSKSSKGGIDQSVLK--ELPPELVAEIESSMPL 1208

  Fly   403 CQQQHEN------------LNIIPTSAEECVLESRASSTNNTVKIPIDTFSTIKAD--------- 446
            |::...|            ...|.:..:|...|:...|.....|...||......|         
 Frog  1209 CERVKMNTRKRSTVKEKPKYTEISSGEDEESEEAFEPSRKRPKKDKADTEWQYDGDRERRSSGDH 1273

  Fly   447 -----EKRSAKRKLAISIGDIPPEQIFSKPKMRRVER----------------ITPLSNTKCVKE 490
                 :.|.:.|....|..|...|:....|::..|.|                :||        |
 Frog  1274 RRSGNDSRKSSRYRERSAEDSEMEESPPPPRLSEVARRMKKERQKKRKAYEPKLTP--------E 1330

  Fly   491 EVTRSQTYQQFIRNMDHIIEILDDSESPNF-DSEDVDETIECISSKLLNSMSTDVAKLKAKQALD 554
            |:..|.|:::|...:::|:|.|:|.:...| |.|::.:.| .:....|:.:.::.||:||...::
 Frog  1331 EMMDSSTFKRFSSAVENILENLEDMDFSAFGDDEEIPQEI-LLGKHQLSELGSESAKIKAMGIMN 1394

  Fly   555 SIPKNKLTLLINYAMRNVY------LARNYFAGTEDEDEFVDDEVIEKLLNAMDACLLICNIYST 613
            .|...|:..|:....:|:.      ...|:...||||::...|.::|::..:.||||...||.::
 Frog  1395 KISSEKMVKLLGILEKNIQDGAKLTTMLNHNNDTEDEEKLWRDLIMERVTKSADACLTAINIMTS 1459

  Fly   614 VSDLQFLQ-EDNVSHIIKFTQFQLRETIFPLHDPVY------------TAKSIKRTTHRKKIKSH 665
            .|..:.:. ||.:.|:|::|:|.|:.|::|.:||||            .||..|.:||::::   
 Frog  1460 PSMPKAVYIEDVIEHVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLMSSKAKRAKCSTHKQRV--- 1521

  Fly   666 QAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVDNIETLQFVCLELVTTI 730
                  :.:.|.|..:::.....|.:..:..||.:|.:|::.|.||||:|:..||...::|||.:
 Frog  1522 ------IVMLYNKICDIVASLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAV 1580

  Fly   731 FRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTNNGGN-----IQMVTALVLQLIQCATIL 790
            |  .||:|.|..||.::.||:.|||:||::||.::|.::..:     ||||||||||||||...|
 Frog  1581 F--SRYEKHRQLILEELFTSLARLPTSKRSLRNFRLNSSDDDGEAMYIQMVTALVLQLIQCVVHL 1643

  Fly   791 PDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQKYDVAVSIGGNFLTTFLNKCKSRSNET 855
            |.            ...:..:|..||:   .||:.:...|:.|:....|||:.||.||.|:..|.
 Frog  1644 PS------------DRDHAEEESNKKI---DQDVFITNSYETAMRTAQNFLSIFLKKCGSKQGEE 1693

  Fly   856 DFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLR 920
            |:|||||||:.|||:|||||||||:||||||||.:||...|:|..|.::|:.||||||.||||||
 Frog  1694 DYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLR 1758

  Fly   921 KDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFDLEPEEQRTDFLQKILLDFLAVNAQ-EE 984
            ||.|.|:.....|:.:     |:|..||           |.:.|:   |||.|||:|..|.: :.
 Frog  1759 KDAVTSKMDQGSINRI-----LKQAPEG-----------EDDIQQ---LQKALLDYLEENTETDP 1804

  Fly   985 NLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKSKIRNNRRTNGDYLDTSDSGSCDESDTD 1049
            :|:  ::|.||:|||:||...:..:....:|.                           |:||..
 Frog  1805 SLV--FSRKFYIAQWFRDTTMETEKAMKSQKD---------------------------DDSDGA 1840

  Fly  1050 TNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPF-SVFGEQNHSSNQHIKTYIDYNNAQLI 1113
            .:.|.:        |...:|.:..|.||::..:.||.. |.|.....:|:.     :||::|.||
 Frog  1841 QHAKEV--------ESTGDIMRRAEKRKKFLRSIIKAVPSQFSTLKSNSDT-----VDYDDACLI 1892

  Fly  1114 AQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFL 1178
            .:|||:.|||:||||..|.:|:.|:.|.:|||||:|||||:.:|.|||.:|.|.|||.||:.:.:
 Frog  1893 VRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLM 1957

  Fly  1179 DTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIP 1243
            |.:.|||||||:|:|:|||....|.:||||||..||||||:||||||||||||||||.|.|.||.
 Frog  1958 DNSTSVREAAVELLGRFVLCRPQLAEQYYDMLVERILDTGISVRKRVIKILRDICLEQPTFPKIT 2022

  Fly  1244 EICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKIGIQRKINHIIDVVNTAHDTGTTWLEGL 1308
            |:||||||||:|||||:|||.|.|.|:||||..:|||..:.|||.:|.|||....|||..|.|.|
 Frog  2023 EMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPQNDKEAMTRKIINITDVVAACRDTGYDWFEQL 2087

  Fly  1309 LMSIFKPRDNMLRS-EGCVQEFIKKNSEPPMDIVIACQQLADGLVDRLIELEDT---------DN 1363
            |       .|:|:| |....:.:||          ||.||.|.||:.:::.|::         ::
 Frog  2088 L-------QNLLKSEEDASYKPVKK----------ACTQLVDNLVEHILKYEESLADSDSKGVNS 2135

  Fly  1364 SRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSATAAKFICAVADILEKVVPLVNNASES 1428
            .|::.|||||.|.:|:||||:||||:|::|||..||.:......||.||.|||.||||:.:.||:
 Frog  2136 GRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSET 2200

  Fly  1429 FLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDVSRSQVIQG-N 1492
            |||::||.||.|::......|..|||||||:|||:|.|:|.:..||.::|..|...:||..:. |
 Frog  2201 FLATMEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNYKFVWACFNRYYGALLKLKSQHQEDPN 2265

  Fly  1493 NSVDNIYTPSFRRSLFTIGILMRYFDFKSPIALGETNDGLPVSICEDVFHCLMFFCRCTNQEIRK 1557
            ::|.....|:..|||||:|.|.|:|||......|.:...:.|:|.:.|...||:|.:..::|::.
 Frog  2266 STVLTTNKPALLRSLFTVGALCRHFDFDQEEFKGSSKVNISVNIKDKVLELLMYFTKHADEEVQT 2330

  Fly  1558 QALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGFKIICMRNIWIYLTESEMFMHNKEKEW 1622
            :|:|.||...:.:.|.:...|:||||..|||...:....||..::|:..||.|.:..|...:::|
 Frog  2331 KAIIGLGFSFIQHPGLMFEVEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDW 2395

  Fly  1623 EKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMV 1687
            :|.||.||||||.|:||||:|.|:||||:::||.|.:...:||.:|:.||.:.|.|||:|||:.|
 Frog  2396 KKMSKQEDLKEMGDISSGMSSSIMQLYLKQVLESFFSTQSSVRHFALNVIALTLNQGLIHPVQCV 2460

  Fly  1688 PYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQLCFKLQKILQIN-NRGKLEIIRG 1751
            ||||.:.||......:::|..|.:|||.|:||::||...|:::.:::|:.:..| ||    .:||
 Frog  2461 PYLIAVGTDPEPAMRNKSDQQLIEIDKKYTGFIHMKAVAGIKMSYQVQQAINSNANR----TVRG 2521

  Fly  1752 YASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDD-QKTSLQQMLYIADNLAYFPYVVQ 1815
            :..   |.:.:||...||:::|..:..|||.:.::...||| .||.:..:||||||||.|||..|
 Frog  2522 FRQ---DESNSALCSHLYSMIRGNRQHRRAFLISLLNLFDDAAKTEVNMLLYIADNLACFPYQTQ 2583

  Fly  1816 DEPLYLIHQIDLLISMAGTHLLATFKEH-IKPSDKEGDV-LED---------------------- 1856
            :|||:::|.||:.:|::|::||.:|||. :|...||..| :||                      
 Frog  2584 EEPLFIMHHIDITLSVSGSNLLQSFKESMVKGKQKEKHVPIEDSNSESEEEVCRPRKTRRRRHSG 2648

  Fly  1857 -DDDVED-PEVLFNRLPEDLTEIIKCITSAQACMLLLILKDHLKEMYAITDSKISRYSPSEQ-KL 1918
             |.|.|| .|.:...||.:.:.:|:...::|..:|||:||.|:|.:...:||||.:|||||. |:
 Frog  2649 SDSDGEDNVEYVLRCLPNNASPLIEFANASQGILLLLMLKQHIKNLCGFSDSKIQKYSPSESAKV 2713

  Fly  1919 YEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDINFTLTKEEKLDLVVKYLDFKQLMLKLDPDD 1983
            |:|.:.||....|:||.|::.:|:.|:  |::.|:..|:.|:        |||||.||..||||:
 Frog  2714 YDKTINRKQGIHFHPKQTLEYLKRNMT--KINDDLKRTIAKQ--------YLDFKLLMEHLDPDE 2768

  Fly  1984 GDSDADESRDKTMLNISASSDGVAFSSSAKNSHSACDGYSLTVTDVV--DVPMSHIAKASMLTSK 2046
            .:.:.:         :|||:|       |:|.         .:|:::  :.|.:::|:.....|.
 Frog  2769 EEEEGE---------VSASTD-------ARNK---------AITNLLGGNSPKNNVAETEEEESD 2808

  Fly  2047 PSGRKTNPVRTKKKRRKIDSTD-----DETSDAE 2075
            ...:.......:|.:|..||:|     :||.|.:
 Frog  2809 GEEKAGGTSGLRKSKRLSDSSDVAAQMNETVDVQ 2842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nipped-BNP_001036451.1 SCC2 560..1901 CDD:467937 558/1405 (40%)
nipblXP_012823388.2 PspC_subgroup_2 <577..954 CDD:468202 8/41 (20%)
PTZ00121 <588..1383 CDD:173412 96/507 (19%)
SCC2 1400..2696 CDD:467937 558/1406 (40%)
HEAT repeat 1947..1975 CDD:293787 15/27 (56%)
HEAT repeat 1984..2010 CDD:293787 22/25 (88%)

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