DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stlk and Stk39

DIOPT Version :9

Sequence 1:	NP_001036442.1	Gene:	Stlk / 3355135	FlyBaseID:	FBgn0046692	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_062235.1	Gene:	Stk39 / 54348	RGDID:	621643	Length:	553	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	93/367 - (25%)
Similarity:	167/367 - (45%)	Gaps:	77/367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YKLLEILKNGMIGTVYKAEDINNKC------LAVKKVSMDQPMEKLTLLFNEVLTVRRLQHRNIN 68
            |:|.|::.:|....|..|     .|      :|:|::::::....:..|..|:..:.:..|.|:.
  Rat    72 YELQEVIGSGATAVVQAA-----LCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 131

  Fly    69 TIVSCFLYKQYVYLTYKFMCFGNCEVLLKNVYTSG------FPEVAIALILKDVLSALTYIHSEH 127
            |..:.|:.|..::|..|.:..|:...::|.:...|      ..|..||.|||:||..|.|:|...
  Rat   132 TYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNG 196

  Fly   128 YVHGSVRAKHILLSPRKAV-LSNFSYCQSFISQG-------EKKTFIFGSTVGIEKELYWTAPEV 184
            .:|..::|.:|||....:| :::|. ..:|::.|       .:|||: |:..       |.||||
  Rat   197 QIHRDLKAGNILLGEDGSVQIADFG-VSAFLATGGDVTRNKVRKTFV-GTPC-------WMAPEV 252

  Fly   185 LYQNLSGYTEKIDIYSIGITCCEMANGFQPFKDTELTYMYIEKVRGSLQVLLDKNSLLENQGSLS 249
            :.| :.||..|.|::|.|||..|:|.|..|:      :.|     ..::||:           |:
  Rat   253 MEQ-VRGYDFKADMWSFGITAIELATGAAPY------HKY-----PPMKVLM-----------LT 294

  Fly   250 LEH---TNKRIARDVIVNKSFSENFHQFVELCLNKNPLSRWAASKLMTHSFLKQCRN-----TSL 306
            |::   |.:....|..:.|.:.::|.:.:.|||.|:|..|..|::|:...|.::.:|     ..|
  Rat   295 LQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 359

  Fly   307 LDQLKDLGQKMSKFKRNEHEIFSDARGS----HNPQPNDTIW 344
            |.:..|:.|:..|.:|        ..||    |..:..|..|
  Rat   360 LTRTPDIAQRAKKVRR--------VPGSSGHLHKTEDGDWEW 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stlk	NP_001036442.1	PK_STRAD	7..312	CDD:270856	84/329 (26%)
Stlk	NP_001036442.1	S_TKc	10..298	CDD:214567	80/310 (26%)
Stk39	NP_062235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		STKc_OSR1_SPAK	70..346	CDD:270787	80/310 (26%)
		S_TKc	72..346	CDD:214567	80/310 (26%)
		Interaction with RELT. /evidence=ECO:0000250\|UniProtKB:Q9Z1W9	319..544		22/83 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	369..375		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..431		7/32 (22%)
		Caspase cleavage related site	396..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810