DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and STK17A

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens

Alignment Length:	294	Identity:	88/294 - (29%)
Similarity:	154/294 - (52%)	Gaps:	16/294 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 PEDDRHAALLTSTGMEINELPSNIRNTYSL--GRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNK 512
            |...:...|||.....:...|  .::.|||  ||.:|.|.||:|.|...:.:|..:|.|.:.|.:
Human    34 PPPPQARGLLTEIRAVVRTEP--FQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRR 96

  Fly   513 CKGKEHYIDA--EVRVMK-KLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFD--AITQVTRFSE 572
             ||::..::.  |:.|:: ..::|.:|:|....:..:.|.|||||.:||::||  ...:...|.|
Human    97 -KGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKE 160

  Fly   573 NQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLA--CEVNDLLYAV 635
            ...:.::|.:...:.:||:..:||.|:||:|:|  |.....:.::|:.||||:  .:.::.|..:
Human   161 KDVQRLMRQILEGVHFLHTRDVVHLDLKPQNIL--LTSESPLGDIKIVDFGLSRILKNSEELREI 223

  Fly   636 CGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPY 700
            .|||.|||||||......:..|:|:.|::.|::|.|..||:..|.|:  .|..|......:.:..
Human   224 MGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQE--TFLNISQMNLSYSEEE 286

  Fly   701 WSDIGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            :..:.:...|.|..:|...|:.|.|:|:.|.|.|
Human   287 FDVLSESAVDFIRTLLVKKPEDRATAEECLKHPW 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	82/265 (31%)
		S_TKc	477..734	CDD:214567	82/265 (31%)
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		1/5 (20%)
		STKc_DRAK1	51..321	CDD:271099	84/277 (30%)
		S_TKc	64..321	CDD:214567	80/262 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900