DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and DCLK1

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001317000.1	Gene:	DCLK1 / 9201	HGNCID:	2700	Length:	740	Species:	Homo sapiens

Alignment Length:	651	Identity:	272/651 - (41%)
Similarity:	375/651 - (57%)	Gaps:	81/651 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 LSNTPTADH------IKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDL 192
            ::..|:..|      .:.|...:.:..:||.:::|||||||::.||...:|.:|:||||.|..||
Human    27 VNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADL 91

  Fly   193 TRLLEENVKIPGAVRTIYNLCG-KKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLSNLPLS 256
            ||.|.:||.:|..|||||.:.| |||:|||:|.:|:||||. :.|.|||:||.....|
Human    92 TRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCG-SIEPFKKLEYTKNVNP------- 148

  Fly   257 NSRSNSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSG 321
            |...|....:..|..|.|                .|..|||   |.:.:....:.|::||:||||
Human   149 NWSVNVKTTSASRAVSSL----------------ATAKGSP---SEVRENKDFIRPKLVTIIRSG 194

  Fly   322 TKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYG 386
            .|||:.:|:||||:.:.||:.|||.||..::||:|.|::::||.|..|:.|.||||.||:|.|.|
Human   195 VKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACG 259

  Fly   387 TERINTAEDFKLEAEEQRAINVIRKTMRT------TGTTCKGPKPKMPIKS------------KK 433
            .|:....:||.|:..|.|   |::.|..|      ..:|.|.|.|....||            .:
Human   260 PEKFRYQDDFLLDESECR---VVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQ 321

  Fly   434 VYPPLVDSEPFKAETTP------EDDRHAALLTS---------------TGMEINE----LPSNI 473
            :..|.....|..:.|:|      ...:|....||               .|.|::|    :|:.|
Human   322 LSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATI 386

  Fly   474 RNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISL 538
            ...|.:||.|||||||:|.:...|.|...||||||.|:||:||||.|..||.:::::.||:|:.|
Human   387 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLL 451

  Fly   539 ILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPEN 603
            |..:|..|.:|||:|.|.|||||||||...:::|..:..|:.:|.:|:.||||:.||||||||||
Human   452 IEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPEN 516

  Fly   604 LLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYIL 668
            |||...:.|: ..|||.|||||..|:..||.||||||||||||:.|.|||||:|:||||:|.|||
Human   517 LLVYEHQDGS-KSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYIL 580

  Fly   669 LCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHS 733
            |||||||....:.||.|||.|:.|..:||.|||.::.|..::||..||..|.|.||::..:|:|.
Human   581 LCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHP 645

  Fly   734 W 734
            |
Human   646 W 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	49/91 (54%)
		DCX	308..396	CDD:214711	41/87 (47%)
		PKc_like	477..734	CDD:304357	140/256 (55%)
		S_TKc	477..734	CDD:214567	140/256 (55%)
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660	49/88 (56%)
		DCX2	182..265	CDD:340589	41/82 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..378		15/90 (17%)
		STKc_DCKL1	383..650	CDD:271085	143/265 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..740
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1465
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1482
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45305
OrthoDB	1	1.010	-	-		D291886at33208
OrthoFinder	1	1.000	-	-		FOG0002635
OrthoInspector	1	1.000	-	-		otm41714
orthoMCL	1	0.900	-	-		OOG6_103814
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4535
SonicParanoid	1	1.000	-	-		X2002
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770