Protein Alignment CG17528 and DCLK3

DIOPT Version :9

• Sequence 1: NP_001036462.1
• Gene: CG17528 / 3355134
• FlyBaseID: FBgn0261387
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: NP_001381601.1
• Gene: DCLK3 / 85443
• HGNCID: 19005
• Length: 817
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 216/797 - (27%)
• Similarity: 307/797 - (38%)
• Gaps: 305/797 - (38%)

  Fly   226 GQSYVCSCNNENFKKVEYNTGSQPLSNLPLSNSRSNSHR--LAKCRPSSPL---KNGLLAGSSPF 285
            ||..:|   :.:.|.:......:.|....|..||.|..:  |....|..||   :|||   .|..
Human    28 GQQGLC---DHSLKYLSSRITERKLQGSWLPASRGNLEKPFLGPRGPVVPLFCPRNGL---HSAH 86

  Fly   286 PACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIR-SGTKPRRIMRLLLNKRNSPSFDHVLTAITQ 349
            |       ..|||            .||:||::: .|.:||:| .||||:|:..:|:.:|..|::
Human    87 P-------ENSPL------------KPRVVTVVKLGGQRPRKI-TLLLNRRSVQTFEQLLADISE 131

  Fly   350 VV---RLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTE----------------------- 388
            .:   |.....|||:|.|.|..:..:||||...|.|.|.|.|
Human   132 ALGSPRWKNDRVRKLFNLKGREIRSVSDFFREGDAFIAMGKEPLTLKSIQVAVEELYPNKARALT 196

  Fly   389 ----------------------------------------------------------------- 388
                                                                             
Human   197 LAQHSRAPSPRLRSRLFSKALKGDHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQ 261

  Fly   389 ------------------------------------------RINTAEDFKLEAEEQRAI----- 406
                                                      .|...|..|.|.|.|:::
Human   262 KKWGRGKWEPEPSSKPPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERL 326

  Fly   407 ------------------NVIR------------------------------------------- 410
                              .::|
Human   327 SLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMD 391

  Fly   411 ---------------------------------------------------------------KT 412
                                                                           |.
Human   392 KKEDRGPEDQESHAQGAAKAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKL 456

  Fly   413 MRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAE----TTPEDDRHAALLTSTGMEINELPSNI 473
            .||.|...:..|.|.|..|......|.|.:|.|.|    |.||:::...........:..:.:|:
Human   457 RRTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANV 521

  Fly   474 RNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISL 538
            ...|..||:|||||||:|.:.:||:|..:||:|||||::.||||..:|:|:.:::.|:||:|:.|
Human   522 EKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKL 586

  Fly   539 ILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPEN 603
            ....:.:..:||:||||.||||||||.:..:|.|..:.:||..|..|:.::|...|||||:||||
Human   587 HEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPEN 651

  Fly   604 LLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYIL 668
            |||:.:|..:. .|||||||||..|...::.|||||||||||||.|.||||::|:||||:|||||
Human   652 LLVQRNEDKST-TLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYIL 715

  Fly   669 LCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHS 733
            |||||||.:|:..|:.||:.|..|.:||..|||.:|.|..:||::.:|..||..|:|:..:|.|.
Human   716 LCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHP 780

  Fly   734 W--TIGNKGNECTTYKR 748
            |  |.|    :..|.||
Human   781 WIETAG----KTNTVKR 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	4/17 (24%)
		DCX	308..396	CDD:214711	34/221 (15%)
		PKc_like	477..734	CDD:304357	133/256 (52%)
		S_TKc	477..734	CDD:214567	133/256 (52%)
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528	32/84 (38%)
		STKc_DCKL3	524..781	CDD:271087	133/257 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1465
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291886at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820