DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and CAMK1

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_005265573.1	Gene:	CAMK1 / 8536	HGNCID:	1459	Length:	413	Species:	Homo sapiens

Alignment Length:	271	Identity:	108/271 - (39%)
Similarity:	165/271 - (60%)	Gaps:	10/271 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 NIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHII 536
            :||:.|....::|.|.|:.|...:.::|....|:|.|.|...:|||..::.|:.|:.|:.||:|:
Human    15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79

  Fly   537 SLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKP 601
            :|....:...::||:::.||||:|||.|.:...::|..:..:|..:..|:.|||.:||||||:||
Human    80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKP 144

  Fly   602 ENLL-VKLDEHGNVLELKLADFGLACEVND---LLYAVCGTPTYVAPEILLEVGYGLKIDVWAAG 662
            |||| ..|||...::   ::||||: ::.|   :|...||||.|||||:|.:..|...:|.|:.|
Human   145 ENLLYYSLDEDSKIM---ISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 205

  Fly   663 IILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSE 727
            :|.||||||:|||.  |.....||:.|:...|||..|||.||.|..:|.|.::::.||:.|||.|
Human   206 VIAYILLCGYPPFY--DENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCE 268

  Fly   728 DILDHSWTIGN 738
            ..|.|.|..|:
Human   269 QALQHPWIAGD 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	104/260 (40%)
		S_TKc	477..734	CDD:214567	104/260 (40%)
CAMK1	XP_005265573.1	STKc_CaMKI_alpha	16..278	CDD:271069	107/267 (40%)
CAMK1	XP_005265573.1	S_TKc	20..276	CDD:214567	104/261 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820