DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and CAMK2B

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_011513849.1	Gene:	CAMK2B / 816	HGNCID:	1461	Length:	709	Species:	Homo sapiens

Alignment Length:	262	Identity:	104/262 - (39%)
Similarity:	150/262 - (57%)	Gaps:	8/262 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 YSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHY-IDAEVRVMKKLNHPHIISLIL 540
            |.|...||.|.|::|.:.....|||.||.|||:..|...::|. ::.|.|:.:.|.|.:|:.|..
Human    14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHD 78

  Fly   541 SVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLL 605
            |:.:....|||.:.|:||:||:.|.....:||..:...|:.:..|:.:.|.||:||||:||||||
Human    79 SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLL 143

  Fly   606 VKLDEHGNVLELKLADFGLACEV---NDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYI 667
            :.....|  ..:||||||||.||   ....:...|||.|::||:|.:..||..:|:||.|:||||
Human   144 LASKCKG--AAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYI 206

  Fly   668 LLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDH 732
            ||.|:|||.  |..|..|:..|.:|.|:||.|.|..:....::||..||..:|..|.|:.:.|.|
Human   207 LLVGYPPFW--DEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKH 269

  Fly   733 SW 734
            .|
Human   270 PW 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	103/260 (40%)
		S_TKc	477..734	CDD:214567	103/260 (40%)
CAMK2B	XP_011513849.1	STKc_CaMKII	12..303	CDD:270988	104/262 (40%)
		S_TKc	14..272	CDD:214567	104/262 (40%)
		CaMKII_AD	577..704	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920