DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and DCDC2C

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_006711957.1	Gene:	DCDC2C / 728597	HGNCID:	32696	Length:	373	Species:	Homo sapiens

Alignment Length:	342	Identity:	92/342 - (26%)
Similarity:	135/342 - (39%)	Gaps:	72/342 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIY 210
            |.||:...|..|..|..|||||.||.|....:|..|..:||.|.|.||    |.|.:|..||.::
Human     4 RGPSAPVDTTPAKTIVVYRNGDPFYVGKKFVLSRRRAATFEALLEQLT----EQVDVPFGVRRLF 64

  Fly   211 N-LCGKKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLSNLPLSNSRSNSHRLAKCRPSSPL 274
            . ..|.::..||.|:.|..|| :...|.||:::|                  .|.:    |..|.
Human    65 TPTRGHRVLGLDALQAGGKYV-AAGRERFKELDY------------------IHIV----PRKPA 106

  Fly   275 KNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSGTKPRRIM---RLLLNKRN 336
            |...|....|...|.           ..:..:....| ||...|...|..|..:   ::::.|.:
Human   107 KIRKLKEIKPVVHCD-----------INVPSKWQTYH-RISRHINVFTNGRLFIPPAKIIIPKFS 159

  Fly   337 SPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFF-AYGTERINTAEDFK--- 397
            ...:|.||..|.:.| ...|.|||:||::|..:....|.  .|:.|: |.|.|.......:|
Human   160 LSDWDIVLATIGEKV-FPLGGVRKLFTMNGHLLGDSKDL--QDNHFYVAVGLETFKYFPYWKSPR 221

  Fly   398 LEAE-EQRAINVIRKTMRTTGTTCKG----------PKPKMPI------KSKKVYPPLV----DS 441
            :.:| :||..||.:.:.|......||          ||.:..:      |.|.:..|||    :.
Human   222 VPSEVQQRYANVEKNSQRKKKVDSKGKEPCKYDGIPPKTQDSVYYAKEEKKKTLAEPLVQRGAEG 286

  Fly   442 EPFKAETTPEDDRHAAL 458
            :.:|| .||..:...||
Human   287 DVYKA-PTPSKETQGAL 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	34/91 (37%)
		DCX	308..396	CDD:214711	25/91 (27%)
		PKc_like	477..734	CDD:304357
		S_TKc	477..734	CDD:214567
DCDC2C	XP_006711957.1	DCX	16..93	CDD:176357	30/81 (37%)
DCDC2C	XP_006711957.1	DCX	154..207	CDD:281590	17/55 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3757
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810