Protein Alignment CG17528 and Dclk2

DIOPT Version :10

• Sequence 1: NP_001036462.1
• Gene: CG17528 / 3355134
• FlyBaseID: FBgn0261387
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: NP_001344389.1
• Gene: Dclk2 / 70762
• MGIID: 1918012
• Length: 772
• Species: Mus musculus
• Alignment Length: 680
• Identity: 268/680 - (39%)
• Similarity: 379/680 - (55%)
• Gaps: 99/680 - (14%)

  Fly   127 SASGSACLSN------TPTADH------IKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSN 179
            |:||.:.:|.      .|:..|      .:.|...:.:..:||.:.:|||||||::.|:...:||
Mouse    29 SSSGGSSISGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISN 93

  Fly   180 ERYRSFERLFEDLTRLLEENVKIPGAVRTIYNLCG-KKITSLDELEDGQSYVCSCNNENFKKVEY 243
            :|:|||:.|..:|||.|.:||.:|..|||||.:.| :|:||||||.:|:||||: :||.|:||:|
Mouse    94 DRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCA-SNEPFRKVDY 157

  Fly   244 NTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVT 308
            .....|  |..::.....:..||.....|.:|.     |..|
Mouse   158 TKNVNP--NWSVNIKGGTTRTLAVASAKSEVKE-----SKDF----------------------- 192

  Fly   309 VVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLS 373
             :.|::||:||||.|||:.:|:||||:.:.||:.|||.||:.::||:|.|:::.||.|..|..|.
Mouse   193 -IKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQ 256

  Fly   374 DFFGSDDVFFAYGTERINTA-EDFKLEAEEQRAI----------------------------NVI 409
            ||||.||||.|.|.|:...| :||.|:..|.|.:                            :|.
Mouse   257 DFFGDDDVFIACGPEKYRYAQDDFVLDHSECRVLKSSYSRASAAKYSGSRSPGFSRRSKSPASVK 321

  Fly   410 RKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINEL----- 469
            |....:..:|.|.|....|  |.::..|........:.|:|...|....:::.|...:.:
Mouse   322 RAGHSSAYSTAKSPVNGTP--SSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNVNGGPE 384

  Fly   470 ------PSNIRNT-----------YSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKE 517
                  |..:...           |.:|::|||||||:|.:...|.||..:|||||||.||.|||
Mouse   385 LDRCLSPEGVNGNRCSESFPLLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKE 449

  Fly   518 HYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHL 582
            |.|:.||.:::::.||:||.|:..::..|:::||:|.|.|||||||||..|:::|.....|:.:|
Mouse   450 HLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNL 514

  Fly   583 GAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEIL 647
            ..|:.||||:.||||||||||||| .:.......|||.|||||..|...||.||||||||||||:
Mouse   515 ANALRYLHSLSIVHRDIKPENLLV-CEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEII 578

  Fly   648 LEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLI 712
            .|.|||||:||||||:|.||||||||||.:.:|.||.|||.|::|..|||.|||.:|.|..::||
Mouse   579 AETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELI 643

  Fly   713 ANMLQADPDVRFTSEDILDHSWTIGNKGNE 742
            :.|||.:.:.|.|:.:||.|.|...:...|
Mouse   644 SQMLQVNVEARCTAGEILSHPWVSDDASQE 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX1	156..239	CDD:340526	44/83 (53%)
		Ubl1_cv_Nsp3_N-like	309..392	CDD:475130	42/82 (51%)
		Protein Kinases, catalytic domain	477..734	CDD:473864	142/256 (55%)
Dclk2	NP_001344389.1	DCX1_DCLK2	70..154	CDD:340661	45/84 (54%)
		DCX2	192..275	CDD:340589	43/106 (41%)
		Protein Kinases, catalytic domain	407..665	CDD:473864	142/258 (55%)