DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and STK33

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	369	Identity:	116/369 - (31%)
Similarity:	193/369 - (52%)	Gaps:	44/369 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 TERINTAED-FKLEAEEQRAINVIRKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTP 450
            |..|.:||. ..||.::::.||                   ..|.|:|..|....:...||....
Human    45 TSSIGSAESLISLERKKEKNIN-------------------RDITSRKDLPSRTSNVERKASQQQ 90

  Fly   451 ------EDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIID 509
                  .:.:...:....|..|.|:       |:.|||:|.|:|.||.:...::|...:|:|.::
Human    91 WGRGNFTEGKVPHIRIENGAAIEEI-------YTFGRILGKGSFGIVIEATDKETETKWAIKKVN 148

  Fly   510 KNKC-KGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSEN 573
            |.|. ......::.||.::|.:.|.|||.|....:....||||:|....|:|.:.:.:...||||
Human   149 KEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSEN 213

  Fly   574 QSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVK---LDEHGNV-LELKLADFGLACEVND---- 630
            ::|.:|:.|.:|:.|||:..|||||:|.||::||   :|::..: |.:|:.|||||.:...
Human   214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEA 278

  Fly   631 LLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYE 695
            :|.|.||||.|:|||::....|..:.|:|:.|:::|:||.|.|||:|  :.:|.||:.|..|...
Human   279 MLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLA--SSEEKLFELIRKGELH 341

  Fly   696 FPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIGNK 739
            |.:..|:.|.|..:.::..:::.||..|.|::::||:.|..|||
Human   342 FENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNK 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711	4/9 (44%)
		PKc_like	477..734	CDD:304357	95/265 (36%)
		S_TKc	477..734	CDD:214567	95/265 (36%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91		8/44 (18%)
		STKc_STK33	114..381	CDD:270999	96/275 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820