DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and CAMK1G

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_065172.1	Gene:	CAMK1G / 57172	HGNCID:	14585	Length:	476	Species:	Homo sapiens

Alignment Length:	269	Identity:	110/269 - (40%)
Similarity:	168/269 - (62%)	Gaps:	6/269 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 SNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHI 535
            :|||.|:....::|.|.|:.||.:|.|.||..:|||.|.|:.. .::..::.|:.|:||:.|.:|
Human    17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPA-FRDSSLENEIAVLKKIKHENI 80

  Fly   536 ISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIK 600
            ::|....:..|:.|||::.||||:|||.|.:...::|..:.::|:.:.:|:.|||..||||||:|
Human    81 VTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 145

  Fly   601 PENLLVKLDEHGNVLELKLADFGLA-CEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGII 664
            |||||....|..:  ::.:.||||: .|.|.::...||||.|||||:|.:..|...:|.|:.|:|
Human   146 PENLLYLTPEENS--KIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVI 208

  Fly   665 LYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDI 729
            .||||||:|||.  :..:..||:.|..|.|||..|:|.||.:..:|.|.::|:.||:.|:|.|..
Human   209 TYILLCGYPPFY--EETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKA 271

  Fly   730 LDHSWTIGN 738
            |.|.|..||
Human   272 LSHPWIDGN 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	103/257 (40%)
		S_TKc	477..734	CDD:214567	103/257 (40%)
CAMK1G	NP_065172.1	STKc_CaMKI_gamma	19..303	CDD:271068	109/267 (41%)
		Autoinhibitory domain. /evidence=ECO:0000250	277..317		2/4 (50%)
		Calmodulin-binding. /evidence=ECO:0000250	297..318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820