DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and spegb

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_021334681.1	Gene:	spegb / 563174	ZFINID:	ZDB-GENE-081104-517	Length:	3608	Species:	Danio rerio

Alignment Length:	829	Identity:	166/829 - (20%)
Similarity:	291/829 - (35%)	Gaps:	228/829 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LSSLQASPSATSPQSVPSKANVVTEASIIEKTNQPHNVQEDNNYNRD----------C------- 65
            ::.|:..||......||...        ||:...|..|:.  .|:.|          |
Zfish  1223 IAKLEKMPSIPEEPEVPENE--------IERFTMPDFVKP--LYDMDVVEGREAVLRCKVAGLPY 1277

  Fly    66 ------DSPESSSSEQDKELDDLRNLHSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVT 124
                  .:.:...|.:|:::...|::|      |:||.....:..|||             ..|.
Zfish  1278 PTITWFHNGKRIDSTEDRKMTQFRDVH------SLVVRCVCHAHGGVY-------------KCVI 1323

  Fly   125 TNSASGSACLSNTPTADHIKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLF 189
            :|....:.|.|:....|.:..  |....|..:::            .|.||.:|.::.:..:...
Zfish  1324 SNKVGKATCYSHLYVTDILPD--PPDGAPVVESI------------TGKTITLSWKKPKRLDPSI 1374

  Fly   190 EDLTRLLEENVKIPGAVR-TIYNLCGKKIT-SLDELEDGQSY---VCSCNNENFKK--------- 240
            :..:.:.....:..|::: ||...|.|:.| ::..|..|..|   |.|..::.|.|
Zfish  1375 DPSSLMYAIQQQALGSIQWTIIASCLKQTTYTISNLSKGVRYAFRVLSITSKAFSKPSPATEPMQ 1439

  Fly   241 -----------------------------------------VEYNTGSQPLSNLP----LSNSRS 260
                                                     |.:..|...|||.|    ||....
Zfish  1440 LLDRGPYVQEAPVIIDKPDIVYMVEKQPLSITVTLNHVNASVTWKRGGVTLSNRPGLFELSMPDD 1504

  Fly   261 NSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSGTKPR 325
            :.|.|..|:..|.....|        .|......||......|.   ..|.|...|::..
Zfish  1505 DQHTLKLCKVKSSDVGQL--------TCIANNKYGSDSCVLTLE---MAVAPTFETIMED----- 1553

  Fly   326 RIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERI 390
                |.:|...:|.|                    ...:.|.||         .|:.:..|...:
Zfish  1554 ----LDVNVGETPRF--------------------AVVVEGKPV---------PDILWYKGDTLL 1585

  Fly   391 NTAEDFKLEAEEQRAINVIRKTMR-TTGT-TCKGPKPKMPIKSKKVYPPLVDSEPFKAETT---- 449
            :.:..|....::.....|:..|.. .:|. ||....             |..|...|||.|
Zfish  1586 SESSHFTFVYDDNECSLVVLNTQADDSGVYTCTAKN-------------LAGSVSCKAELTVHTT 1637

  Fly   450 ------PEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKII 508
                  |.:| .|::|...        ..:.:.|.:.:.||.|.|:.|.::..:.....||.|.|
Zfish  1638 KQYKDDPMED-EASILRKM--------RRLTDYYDVHKEIGRGAFSYVKRVIQKAGKLEYAAKFI 1693

  Fly   509 DKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSEN 573
            .. :.|.|...: .|:.::..|:|..|: ......:..|..:::..:...:|.|.:|:.:...|:
Zfish  1694 SA-RAKRKASAL-RELNILSHLDHERIL-YFHDAFEKKNAVIIITELCHEELLDRLTKKSTILES 1755

  Fly   574 QSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEV--NDLLYAVC 636
            :.|..:|.|...:.|||.:.|:|.||||:|:|  :.:|.:. ::::.|||.|.:.  ::..|...
Zfish  1756 EIRSSVRQLLEGINYLHQLDILHLDIKPDNIL--MADHSSD-QIRICDFGNAVKFMPDEAQYCKY 1817

  Fly   637 GTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYW 701
            |||.:|||||:.:.......|:|..|::.|:.|.|..|| |.:|.:..:.: |.:....|.:..:
Zfish  1818 GTPEFVAPEIVNQTPVSKATDIWPIGVLTYLCLTGVSPF-AGENDRSSVLN-IRNYNVAFEESMF 1880

  Fly   702 SDIGDGVRDLIANMLQAD---PDVRFTSEDILDHSW--TIGNKGNECTT 745
            :|:....:..:..:|.||   ||    :.:.|.|.|  |: |||...:|
Zfish  1881 TDLCHEAKGFVIKLLVADRLRPD----ANECLRHPWFKTL-NKGKSIST 1924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	19/145 (13%)
		DCX	308..396	CDD:214711	12/87 (14%)
		PKc_like	477..734	CDD:304357	69/261 (26%)
		S_TKc	477..734	CDD:214567	69/261 (26%)
spegb	XP_021334681.1	I-set	55..137	CDD:254352
		DUF4045	<228..687	CDD:330572
		I-set	781..870	CDD:254352
		I-set	928..1018	CDD:254352
		I-set	1029..1117	CDD:254352
		I-set	1123..1212	CDD:254352
		I-set	1249..1338	CDD:254352	19/109 (17%)
		FN3	1343..1436	CDD:238020	19/106 (18%)
		Ig	<1479..1541	CDD:325142	17/72 (24%)
		I-set	1545..1634	CDD:254352	22/139 (16%)
		PKc_like	1659..1913	CDD:328722	69/265 (26%)
		I-set	2861..2949	CDD:254352
		FN3	2955..3044	CDD:238020
		PKc_like	3296..3552	CDD:328722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900