DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17528 and trioa

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_021323750.1	Gene:	trioa / 557667	ZFINID:	ZDB-GENE-060503-334	Length:	3115	Species:	Danio rerio

Alignment Length:	367	Identity:	101/367 - (27%)
Similarity:	167/367 - (45%)	Gaps:	54/367 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 TCKGPKPKMPIKSKKVYPPLVDSEPFK---AET----------TPEDD---------------RH 455
            |.|||:.|          .|.::..|.   :||          |.|||               ..
Zfish  2734 TWKGPEQK----------TLTNNGHFSIAYSETGEATLRIVGVTSEDDGSYTCIATNDIGSVASS 2788

  Fly   456 AAL----LTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGK 516
            |:|    .||.|:.: ....|..:.|:....:|.|.|::|.:...|.:..:.|:|.::|...|..
Zfish  2789 ASLRVLGTTSDGIRV-MWKDNFESFYTEVAELGRGRFSVVKRCDQRGSKRTVAVKFVNKKLMKRD 2852

  Fly   517 EHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRH 581
            :  :..|..|:::|.|||::.|:.:.:.:::..||||....|.|.|.|......:|.:....:|.
Zfish  2853 Q--VTHEFSVLQRLQHPHLVRLLDTFETSSSYALVLEMSDQGRLLDYIVSWGNLTEEKVAFYLRD 2915

  Fly   582 LGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYA--VCGTPTYVAP 644
            :..|:.|||:..|||.|:|||||:|  ::..:...:||.|||.|.::|...|.  :.|:|.:.||
Zfish  2916 ILEALQYLHNCRIVHLDLKPENLVV--EQSPSQPLVKLTDFGDAVQLNSTPYVHPLLGSPEFAAP 2978

  Fly   645 EILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVR 709
            |::|.....|..|:|:.|::.|::|.|..||:  |...|.....|....:.|||.|:..:....|
Zfish  2979 ELVLGDPVSLSSDLWSLGVLTYVMLSGASPFL--DESVEETCLNICRLDFSFPDDYFQGVSQAAR 3041

  Fly   710 DLIANMLQADPDVRFTSEDILDHSWTI---GNKGNECTTYKR 748
            |.:..:|:.:|..|..:...|...|..   |.:..||....|
Zfish  3042 DFMCLLLRMEPSKRPPATSCLQEPWLRAGGGRRSAECIDTSR 3083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	77/258 (30%)
		S_TKc	477..734	CDD:214567	77/258 (30%)
trioa	XP_021323750.1	SEC14	61..199	CDD:214706
		SPEC	212..447	CDD:238103
		SPEC	343..589	CDD:238103
		SPEC	590..806	CDD:238103
		SPEC	810..1037	CDD:238103
		SPEC	931..1160	CDD:238103
		SPEC	1166..1266	CDD:197544
		RhoGEF	1316..1488	CDD:238091
		PH1_Kalirin_Trio_like	1495..1627	CDD:270060
		SH3_Kalirin_1	1695..1754	CDD:212786
		SH3-RhoG_link	1752..2000	CDD:318750
		RhoGEF	2007..2180	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2185..2324	CDD:270061
		Atrophin-1	<2364..2523	CDD:331285
		SH3_Kalirin_2	2570..2628	CDD:212787
		I-set	2702..2793	CDD:254352	15/68 (22%)
		PKc_like	2805..3067	CDD:328722	78/267 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900