DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17528 and Mapkapk5

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001157515.1	Gene:	Mapkapk5 / 498183	RGDID:	1564113	Length:	473	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	93/303 - (30%)
Similarity:	153/303 - (50%)	Gaps:	52/303 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 SNIRNTYSLG--RIIGDGNFAIVFKIKHRQTGHSYALKI-IDKNKCKGKEHYIDAEVRV-MKKLN 531
            ::|...||:.  :.:|.|....|.....:.|...:|||| :|:.|.:.       |||: |....
  Rat    14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARN-------EVRLHMMCAT 71

  Fly   532 HPHIISLILSVDQNT-----------NMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAA 585
            |.:|:. |:.|..|:           .:.:|:|.:.||:||..|:|...|:|.|:..:.:.:..|
  Rat    72 HSNIVE-IIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALA 135

  Fly   586 MTYLHSMGIVHRDIKPENLLVKLDEHGNVLE--LKLADFGLA-CEVNDLLYAVCGTPTYVAPEIL 647
            :.:.|.:.|.|||:||||||.|    .|.|:  :||.|||.| .:..||:.... ||.||||::|
  Rat   136 LQHCHLLNIAHRDLKPENLLFK----DNSLDAPVKLCDFGFAKVDQGDLMTPQF-TPYYVAPQVL 195

  Fly   648 ------------------LEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQ---EPLFDAIIS 691
                              ....|....|:|:.|:|:|::|||:|||.:..:.:   :.:...|::
  Rat   196 EAQRRHQKEKSGLIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMT 260

  Fly   692 GIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            |.:|||:..||.|.:..:|::..:|:..|:.|.|.|.:|||.|
  Rat   261 GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	91/295 (31%)
		S_TKc	477..734	CDD:214567	91/295 (31%)
Mapkapk5	NP_001157515.1	STKc_MAPKAPK5	15..304	CDD:271073	93/302 (31%)
Mapkapk5	NP_001157515.1	S_TKc	26..304	CDD:214567	90/291 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930