DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and mylkb

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_009300538.1	Gene:	mylkb / 492576	ZFINID:	ZDB-GENE-041111-150	Length:	966	Species:	Danio rerio

Alignment Length:	821	Identity:	196/821 - (23%)
Similarity:	324/821 - (39%)	Gaps:	192/821 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SPSATSPQS-VPSKANVVTEASIIEKTNQPHNVQ-EDNNYNRDCDSPESSSSEQDKELDDLRNLH 86
            :|.||:|.| .||...     |::.|.....:|: |:...|....:|::...|
Zfish    43 APVATTPPSRGPSDFR-----SVLSKKQAAESVKTEEKEQNSTKPAPKTPQKE------------ 90

  Fly    87 SSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSACLSNTPTADHIKKRIPSSR 151
                       |.:| :|||.. .:|..::...|:..||.....|.  ::..|....:|..|..:
Zfish    91 -----------KQSG-VNGVNG-GAVDKKSTLKENTTTTTEKKDSK--TDAGTIGKKEKSSPEKK 140

  Fly   152 TPTRKALRI--KFYRNGDRFYPG-----------ITIPVSNERYRSFERLFEDL----TRLLEEN 199
            |...:....  |...||.....|           ||: |..||.|...::..||    |.:|:..
Zfish   141 TSDGQITESNDKKVVNGGEKDAGKPPVFKQPLSDITV-VDGERLRLECQVTSDLQAAITWILDGK 204

  Fly   200 VKIPGAVRTIYNLCGKKITSLDEL--EDGQSYVCSCNNENFKK-----VEYNTGSQPLSNLPLSN 257
            ...|.....:.:...|...::|:.  ||...|.|...|.:.|.     |..:..|.|.::.....
Zfish   205 TVKPSKFIVLSHEGEKCSLTIDKALPEDEGRYTCRAENAHGKAECSCVVTVDDPSDPSADKKNRK 269

  Fly   258 SRS------NSHRLAKCRPSSPLKNG---------------------LLA--GSSPFPAC----- 288
            |.|      |..|:.| :| :|.|.|                     ||.  |.||...|
Zfish   270 SSSATPTTENEARIKK-KP-APTKQGSPPQFLHFPGDQKIRAGEKVELLGNFGGSPPITCTWLKF 332

  Fly   289 -------GGG-----TGNGSPL-IASRLSDRVTVVHPRIVTL---IRSGTKPRRIMRLLLNKRNS 337
                   .||     |.|.|.| ||:...|     |....||   .:.|.|...:...:::|.:.
Zfish   333 KKPIQPGNGGISIETTENSSQLTIAASDQD-----HCGCYTLELQNKFGLKQASLNLTIVDKPDP 392

  Fly   338 PSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGT--ERINTAEDFKLEA 400
            |                          :|||..  ||...|......||.  :..:..:.:.||
Zfish   393 P--------------------------AGIPAA--SDIRRSSLTLSWYGPTYDGGSIVQSYNLE- 428

  Fly   401 EEQRAINVIRKTMRTTGTTCKGP-----------KPKMPIKSKKVY---PPLVDSEPFKA---ET 448
                ..|.:..|.... |:|...           :.|..:::..||   .|..:|.|.:.   |.
Zfish   429 ----IWNSVDNTWNDL-TSCNSTSFHVQNLLSDRQYKFRVRAVNVYGVGEPSAESGPIEVGAEEV 488

  Fly   449 T--PEDDRHAALLTSTGME--------INELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSY 503
            |  .|::...|.::....|        :.:...::::.|.:...:|.|.|..|||:..:.:...:
Zfish   489 TEKKEEEEVGAAVSDDDEEKEPEYRDVVIKKDCSVKDFYDIEDRLGTGKFGQVFKLVEKSSKKVW 553

  Fly   504 ALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVT 568
            |.|.|.....|.||: :..|:.:|..|:||.::..:.:.:..::|.:|:|.:|||:||:.|  |.
Zfish   554 AGKFIKAFSQKEKEN-VRQEIGIMNSLHHPKLVQCMDAFEGKSDMVMVMEMISGGELFERI--VD 615

  Fly   569 RFSENQSRIMIRHLGA---AMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVND 630
            ...|...|.:|:::..   .:.::|..||||.|:||||::. :::.|:  ::||.|||||..:.|
Zfish   616 EDFELTEREVIKYMLQIIDGVQFIHKQGIVHLDLKPENIMC-INKTGS--KIKLIDFGLARRLED 677

  Fly   631 --LLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGI 693
              .|..:.|||.:||||::.........|:|:.|:|.|||:.|..||:. ||..|.|.: :.|..
Zfish   678 SGSLKVLFGTPEFVAPEVINYEAISYPTDMWSIGVICYILVSGLSPFMG-DNDNETLAN-VTSAT 740

  Fly   694 YEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            ::|.|..:.:|.|..:|.|:.:|:.|...|.|.....:|||
Zfish   741 WDFEDEAFDEISDQAKDFISRLLKKDMRARLTCAQCFEHSW 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	24/114 (21%)
		DCX	308..396	CDD:214711	15/92 (16%)
		PKc_like	477..734	CDD:304357	84/261 (32%)
		S_TKc	477..734	CDD:214567	84/261 (32%)
mylkb	XP_009300538.1	I-set	166..255	CDD:254352	20/89 (22%)
		IGc2	180..245	CDD:197706	15/64 (23%)
		Ig	296..394	CDD:299845	22/128 (17%)
		I-set	296..386	CDD:254352	20/94 (21%)
		FN3	390..475	CDD:238020	18/118 (15%)
		PKc_like	524..782	CDD:304357	86/266 (32%)
		Pkinase	527..782	CDD:278497	86/263 (33%)
		I-set	860..950	CDD:254352
		IGc2	873..940	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010