DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and MYLK

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens

Alignment Length:	850	Identity:	198/850 - (23%)
Similarity:	338/850 - (39%)	Gaps:	208/850 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SPQSVPSKANVVTEASIIEKTNQPHNVQEDNNYNRDCDS--------PESSSSEQDKELDDLRNL 85
            |||.|..::.:..:.:  .||..|..|........|..|        |..:.|...:.|:.....
Human   957 SPQQVDFRSVLAKKGT--SKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVE 1019

  Fly    86 HSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSACLSNTPTADHIKKRIPSS 150
            .|..|:|:    :.:|.|..|.:    ....:||:.:.....|.....:.|....:::|.   :|
Human  1020 SSKPLSNA----QPSGPLKPVGN----AKPAETLKPMGNAKPAETLKPMGNAKPDENLKS---AS 1073

  Fly   151 RTPTRKALRIKFYRNGDRFYPGITIPVSNERYRS--------FERLFEDL------TRLLEENVK 201
            :...:|  .:|...|..|.:.|.|   .||: ||        |::..:|:      ..||:..|.
Human  1074 KEELKK--DVKNDVNCKRGHAGTT---DNEK-RSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVS 1132

  Fly   202 IPGAVRTIYNLCGKKI----------------TSLDEL--ED------------GQSYVCSCN-- 234
            .......|:.|.||.:                .|:::.  ||            ||: .|||.
Human  1133 SDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQA-ECSCQVT 1196

  Fly   235 ------NENFKKVEYNTGSQPLSNL-PLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFP------ 286
                  :||.|..|..: .:|.|:| |:..:.|::....|..|.:|.|..:......||
Human  1197 VDDAPASENTKAPEMKS-RRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVR 1260

  Fly   287 ------ACGGGTG---------------------------NGSPL--IASRLSDRVTVVHPRIVT 316
                  ..|..||                           |||.|  :|:|..      |....|
Human  1261 AGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQE------HCGCYT 1319

  Fly   317 LI---RSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGS 378
            |:   :.|::..::...:::|.:.|:.    |.....:|..:      .|||         ::||
Human  1320 LLVENKLGSRQAQVNLTVVDKPDPPAG----TPCASDIRSSS------LTLS---------WYGS 1365

  Fly   379 D----DVFFAYGTERINTA-----------------------EDFKLEAEEQRAINV--IRKTMR 414
            .    ....:|..|..::|                       .::|...   |||||  ..:..:
Human  1366 SYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRV---RAINVYGTSEPSQ 1427

  Fly   415 TTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSL 479
            .:..|..|.||:.|....:|    .|.:    |..||.| :..:..:|..::::.       |.:
Human  1428 ESELTTVGEKPEEPKDEVEV----SDDD----EKEPEVD-YRTVTINTEQKVSDF-------YDI 1476

  Fly   480 GRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQ 544
            ...:|.|.|..||::..::|...:|.|.......|.||: |..|:.:|..|:||.::..:.:.::
Human  1477 EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN-IRQEISIMNCLHHPKLVQCVDAFEE 1540

  Fly   545 NTNMYLVLEYVSGGDLFD-AITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKL 608
            ..|:.:|||.||||:||: .|.:....:|.:....:|.:...:.|:|..||||.|:||||::. :
Human  1541 KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMC-V 1604

  Fly   609 DEHGNVLELKLADFGLACEVNDL--LYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCG 671
            ::.|.  .:||.|||||..:.:.  |..:.|||.:||||::.....|...|:|:.|:|.|||:.|
Human  1605 NKTGT--RIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSG 1667

  Fly   672 FPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTI 736
            ..||:. ||..|.|.: :.|..::|.|..:.:|.|..:|.|:|:|:.|...|......|.|.|.:
Human  1668 LSPFMG-DNDNETLAN-VTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM 1730

  Fly   737 GNKGN 741
            .:..|
Human  1731 KDTKN 1735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	31/142 (22%)
		DCX	308..396	CDD:214711	16/117 (14%)
		PKc_like	477..734	CDD:304357	86/259 (33%)
		S_TKc	477..734	CDD:214567	86/259 (33%)
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352	17/89 (19%)
		Ig8_hMLCK_like	1248..1345	CDD:143239	16/102 (16%)
		FN3	1341..1433	CDD:238020	17/113 (15%)
		STKc_MLCK1	1471..1729	CDD:271093	86/270 (32%)
		I-set	1819..1909	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010