DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17528 and Obscn

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001164983.2	Gene:	Obscn / 380698	MGIID:	2681862	Length:	8032	Species:	Mus musculus

Alignment Length:	681	Identity:	143/681 - (20%)
Similarity:	258/681 - (37%)	Gaps:	159/681 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 DHIKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYR--SFERLFEDLTRLLEENVKI- 202
            |.::|.:..:||...|...:|       ...||...::...:|  .||....|.|..|.|.||:
Mouse  6206 DSVRKYLLQARTVIIKNSWVK-------EICGIQQRLAQPVWRPPEFEEELADCTAELGETVKLA 6263

  Fly   203 ------PGAVRTIY-------------------NLCGKKITSLDELEDGQSYVCSCNNENFKKVE 242
                  |..:.:.|                   ..|...:.:|..::.|| |:|..
Mouse  6264 CRVTGTPKPIVSWYKDGKPVEVDPHHILIEDPDGSCTLILDNLTGIDSGQ-YMCFA--------- 6318

  Fly   243 YNTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFP-------ACGGGTGNGSPLIA 300
                         :::..|:..|.|.....|.:......::||.       .|   |..|:|
Mouse  6319 -------------ASAAGNASTLGKILVQVPPRFVNKVRATPFVEGEDAQITC---TVEGAP--- 6364

  Fly   301 SRLSDRVTVVHPRI-----VTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGY--- 357
                      :|:|     .||:..|.:.|.:        |.|....::..|....:.|.|:
Mouse  6365 ----------YPQIRWYKDGTLLAPGNRYRML--------NEPRSGVLVLVIQAASKEDLGHYEC 6411

  Fly   358 --VRKVFTLSG-------IPVVRLSDFFGSDDVFFAY-GTERIN-TAEDFKLEAEEQRAINVI-- 409
              |.::.:..|       .|.:|..|....:.:..|. |...:. |.||.:::..:....:.:
Mouse  6412 ELVNRLGSTRGGGELYMQSPALRARDQHHREQIVAAVEGAPSMQVTIEDVQVQVGDMAQFDAVIE 6476

  Fly   410 --------------------RKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEP----FKAETTP 450
                                |.:.|..|||.......:......||..:.::..    .|||
Mouse  6477 GHPPPIVTWYKGSTQLTSSARLSQRQDGTTYSLVLTDVAPHDAGVYTCVANNAGGQVLCKAE--- 6538

  Fly   451 EDDRHAALLTSTGMEI---NEL-PSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIID-K 510
                   ||...|.::   |:: ...:.:.|.:...||.|.|..|.:::|:......|.|.|. :
Mouse  6539 -------LLVHGGDKLDAENQVYRRKLHSFYDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLR 6596

  Fly   511 NKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQS 575
            :|.:.:.:   .|..::..|.||.:..|:...:....:.|:||..|..:|.|.:.:....:|.:.
Mouse  6597 SKTRAQAY---QERDILATLGHPLVTGLLDQFETRKTLILILELCSSEELLDRLFKKGVVTEAEV 6658

  Fly   576 RIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEV--NDLLYAVCGT 638
            ::.|:.|...:.||||.||:|.||||.|:|:   .|....::|:.|||.|.::  ::..|:..|:
Mouse  6659 KVYIQQLVEGLHYLHSHGILHLDIKPPNILM---VHPAREDIKICDFGFAQKITPSEPQYSKYGS 6720

  Fly   639 PTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSD 703
            |.:|:|||:.:.......|:||.|:|.|:.|....|| |.::.:..|.: ::.|...:..|..:.
Mouse  6721 PEFVSPEIIEQNPVSEGSDIWAMGVISYLSLTCSSPF-AGESDRATLLN-VLEGRVSWSSPTAAH 6783

  Fly   704 IGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            :.:..:|.|...||..|..|.::...|.|.|
Mouse  6784 LSEDAKDFIKATLQRTPRARPSTSQCLAHPW 6814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	21/118 (18%)
		DCX	308..396	CDD:214711	20/106 (19%)
		PKc_like	477..734	CDD:304357	72/259 (28%)
		S_TKc	477..734	CDD:214567	72/259 (28%)
Obscn	NP_001164983.2	I-set	3855..3938	CDD:254352
		IGc2	3868..3926	CDD:197706
		I-set	3943..4026	CDD:254352
		Ig_2	3951..4021	CDD:290606
		I-set	4031..4114	CDD:254352
		IGc2	4044..4102	CDD:197706
		I-set	4119..4202	CDD:254352
		I-set	4208..4291	CDD:254352
		ig	4211..4279	CDD:278476
		I-set	4297..4380	CDD:254352
		Ig	4313..4381	CDD:143165
		I-set	4385..4471	CDD:254352
		Ig	4399..4464	CDD:299845
		I-set	4478..4563	CDD:254352
		Ig	4490..4547	CDD:299845
		I-set	4566..4654	CDD:254352
		I-set	4660..4745	CDD:254352
		FN3	4749..4834	CDD:238020
		I-set	4862..4923	CDD:254352
		I-set	5127..5217	CDD:254352
		Ig	5144..5213	CDD:143165
		I-set	5357..5447	CDD:254352
		Ig	5375..5444	CDD:143165
		I-set	5489..5579	CDD:254352
		Ig	5513..5579	CDD:299845
		Ig	5599..5695	CDD:299845
		I-set	5600..5695	CDD:254352
		SH3_Obscurin_like	5831..5893	CDD:212958
		RhoGEF	5926..6102	CDD:295373
		PH_Obscurin	6111..6235	CDD:270059	8/35 (23%)
		I-set	6243..6335	CDD:254352	19/114 (17%)
		Ig	8..90	CDD:299845
		I-set	9..98	CDD:254352
		I-set	109..200	CDD:254352
		Ig	126..190	CDD:143165
		IG	246..326	CDD:214652
		Ig	250..319	CDD:299845
		I-set	333..416	CDD:254352
		I-set	423..499	CDD:254352
		FN3	513..600	CDD:238020
		I-set	615..>671	CDD:254352
		IGc2	<732..781	CDD:197706
		IGc2	878..941	CDD:197706
		IGc2	970..1033	CDD:197706
		IGc2	1062..1125	CDD:197706
		IGc2	1154..1217	CDD:197706
		IGc2	1246..1309	CDD:197706
		IGc2	1338..1401	CDD:197706
		IGc2	1430..1493	CDD:197706
		IGc2	1522..1585	CDD:197706
		IGc2	1614..1677	CDD:197706
		IGc2	1706..1769	CDD:197706
		IGc2	1798..1861	CDD:197706
		IGc2	1891..1950	CDD:197706
		I-set	1967..2050	CDD:254352
		Ig	1983..2051	CDD:143165
		I-set	2057..2140	CDD:254352
		IGc2	2069..2132	CDD:197706
		I-set	2147..2229	CDD:254352
		I-set	2324..2406	CDD:254352
		Ig	2331..2395	CDD:299845
		I-set	2449..2530	CDD:254352
		Ig	2464..2531	CDD:143165
		I-set	2626..2709	CDD:254352
Ig	2642..2710	CDD:143165
I-set	2716..2798	CDD:254352
I-set	2804..2887	CDD:254352
Ig	2820..2888	CDD:143165
I-set	2894..>2962	CDD:254352
I-set	2985..3065	CDD:254352
Ig_2	2989..3060	CDD:290606
I-set	3073..3156	CDD:254352
IG	3168..3247	CDD:214652
I-set	3254..3336	CDD:254352
Ig_2	3258..3337	CDD:290606
I-set	3342..3425	CDD:254352
ig	3346..3412	CDD:278476
I-set	3431..3513	CDD:254352
IGc2	3443..3501	CDD:197706
I-set	3519..3601	CDD:254352
IGc2	3531..3589	CDD:197706
I-set	3612..3689	CDD:254352
IGc2	3619..3677	CDD:197706
I-set	3695..>3763	CDD:254352
I-set	3768..3850	CDD:254352
IGc2	3780..3838	CDD:197706
Ig	6260..6327	CDD:143165	11/89 (12%)
IG_like	6349..6427	CDD:214653	17/101 (17%)
IGc2	6350..6418	CDD:197706	16/91 (18%)
I-set	6452..6541	CDD:254352	14/98 (14%)
Ig	6475..6538	CDD:143165	8/62 (13%)
PKc_like	6559..6815	CDD:304357	73/264 (28%)
S_TKc	6562..6815	CDD:214567	73/261 (28%)
IGc2	7540..7606	CDD:197706
FN3	7620..7698	CDD:214495
PKc_like	7732..7988	CDD:304357
S_TKc	7741..7984	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900