DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and Dclk3

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001178729.1	Gene:	Dclk3 / 316023	RGDID:	1309232	Length:	807	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	217/774 - (28%)
Similarity:	306/774 - (39%)	Gaps:	302/774 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 PSSPLKNGLLAGSSPFPACGGGTG---NGSPLIASRLSDR------------------------- 306
            |..|......|.|.|.||..|..|   :....::|::|:|
  Rat    10 PPPPATPAPPAPSRPAPAISGHRGPCDHSLKCLSSKISERKLPGSWLPSGRGPLEKPVLGPRGAV 74

  Fly   307 ------------VTVVH----PRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVV---R 352
                        |...|    ||:||:::.|.:|.|...||||:|:..:|:.:|:.|::.:   |
  Rat    75 MPMFSPQSSLHSVRAEHSPLKPRVVTVVKLGVQPLRKATLLLNRRSVQTFEQLLSDISEALGFPR 139

  Fly   353 LDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTAEDFKLEAEE----QRAINVI---- 409
            .....|||:|||.|..|..:||||...|.|.|.|.|.: |.:..:|..||    .||:.:.
  Rat   140 WKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPL-TLKSIQLAMEELYPKNRALALAPHSR 203

  Fly   410 ----RKTMRTTGTTCKG------------------------------------------------ 422
                |...|......||
  Rat   204 VPSPRLRSRLPSKLLKGSHRCGEAGSYGEVMGNKAVIRHQGKTSTELAPEDKARAQKKWVGGKQE 268

  Fly   423 ------PKPK--------------MPIKSKKVYPPLVDSEPFKAET------------------- 448
                  |.|:              :.::.:|....:|..|..|.||
  Rat   269 SENGGLPSPREATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRETELQLGLQRGQCPPGTSELD 333

  Fly   449 ----------------------------------------TPEDD-------------------- 453
                                                    :|.|.
  Rat   334 LGRGQKRDSEKLVRTKSCRRASEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNNNSDKKESRGSE 398

  Fly   454 ----------------------------------------RHAALL------------------- 459
                                                    :|||.|
  Rat   399 AQESHPQGVAKAQKDLMEGLPAVEEGAVDARRDSRHTCRIKHAAWLRREQQAEPPQLPRTRGEEK 463

  Fly   460 --------------------TSTGMEIN--ELPS------------NIRNTYSLGRIIGDGNFAI 490
                                :.|..|.|  |.||            ::...|.:||:||||||||
  Rat   464 EAEHEKKSGGLGGRRMLEKESKTKPEENRPERPSGRKLRPTGIISADVEKHYDIGRVIGDGNFAI 528

  Fly   491 VFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYV 555
            |.:.|||:|..:||:|||||::.||||..:|:|:.:::.|:||:|:.|....:....:||::|||
  Rat   529 VKECKHRETRQAYAMKIIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYV 593

  Fly   556 SGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLA 620
            .||||||||.:..:|.|..:.:||..|..|:.::|...|||||:|||||||:.:|..:. .||||
  Rat   594 QGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKKIVHRDLKPENLLVQRNEDKST-TLKLA 657

  Fly   621 DFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPL 685
            |||||..|...::.|||||||||||||.|.||||::|:||||:||||||||||||.:|:..|:.|
  Rat   658 DFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDEL 722

  Fly   686 FDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIGNKGNECT 744
            |:.|..|.:||..|||.:|.|..:||:.|:|..||..|:|:..:|.|.| ||..|:..|
  Rat   723 FNIIQLGQFEFLSPYWDNISDAAKDLVRNLLVVDPKKRYTAHQVLHHPW-IGMVGHPST 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711	35/94 (37%)
		PKc_like	477..734	CDD:304357	135/256 (53%)
		S_TKc	477..734	CDD:214567	135/256 (53%)
Dclk3	NP_001178729.1	UBQ	92..177	CDD:294102	33/84 (39%)
		PKc_like	514..771	CDD:304357	135/257 (53%)
		S_TKc	515..772	CDD:214567	136/258 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291886at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820