DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and Mylk3

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001104280.1	Gene:	Mylk3 / 291926	RGDID:	1305801	Length:	786	Species:	Rattus norvegicus

Alignment Length:	848	Identity:	173/848 - (20%)
Similarity:	282/848 - (33%)	Gaps:	252/848 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QASPSATSPQSVPS-----------KANVVTEASIIEKTNQPHNVQEDNNYNRDC---------- 65
            :..|....||.:|:           |.||:|     ||.::..:.|||......|
  Rat     6 EEDPEGLGPQGLPALGGACLVTVDKKLNVLT-----EKVDRLLHFQEDVTEKLQCVCQGMDHLEQ 65

  Fly    66 ------------------DSPESSSSEQDKELDDLR---------------------------NL 85
                              .||.::.:...:.|:.:|                           .|
  Rat    66 GLHRLEASQELGLAGPGSTSPAAAQAAWPEVLELVRAVRQEGAQHGARLEALFKMVVAVDRAITL 130

  Fly    86 HSSSLTNSVV--------VGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSACLSNTPTADH 142
            ..|::.||.|        |....|||..........:|...::.....|:.|..|..|.....:.
  Rat   131 VGSTIQNSKVDDFILQGTVPWRKGSLADGPEENKEQAEVAGVKPKHVLNTGSVQAATSRALWEES 195

  Fly   143 IKKRIP-----------------SSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLFE 190
            .|:..|                 :..|....:||    :..:...||...|.:....|......|
  Rat   196 QKQDTPVGTVEGLPLIIDTSLKGADLTQAGASLR----QGVEALDPGQEPPPAEAESRLPALASE 256

  Fly   191 DLTRLLEENVKIPGAVRTIYNLCGKKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLSNLPL 255
            |....||.:|.|......:.:|  :...|..|........||           ..|.|||..|..
  Rat   257 DTGTTLELSVAIDRISEVLTSL--RMSQSAGEGTSSSKPDCS-----------EPGPQPLGPLTT 308

  Fly   256 SNSRSNSHRLAKCR----------------------------PSSPLKNGLLAGSSPFP-----A 287
            .:...:...|.:..                            |.:.|::.:..|:.|||     :
  Rat   309 DSDIHSDEGLPRISVRMREMTTPEELFETQGGSPIGSAEAPGPGTVLEDQIPKGARPFPPLPKRS 373

  Fly   288 CGGG-------TGNGS-PLIASRLSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVL 344
            |..|       ||.|: |:....|..|.....|...|.::.|..|..:       ...|..||
  Rat   374 CNNGGASAEEATGPGAEPIRGPSLVTRDWRDEPVGTTDLQQGRDPGAV-------SPEPGKDH-- 429

  Fly   345 TAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTAEDFKLEAEEQRAINVI 409
             |.....|.:.|  |:|.:.:...:|.|.|
  Rat   430 -AAQGPGRTEAG--RRVSSAAEAAIVVLDD----------------------------------- 456

  Fly   410 RKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIR 474
                                   ...||    .||:.......|    .|.||..
  Rat   457 -----------------------SAAPP----APFEHRVVSIKD----TLISTSY---------- 480

  Fly   475 NTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLI 539
             |.|...::|.|.|..|.:...|.||.:.|.|||.....|.:|. :..|:.:|.:|:|.::|.|.
  Rat   481 -TVSQHEVLGGGRFGQVHRCTERSTGLALAAKIIKVKNIKDRED-VKNEINIMNQLSHVNLIQLY 543

  Fly   540 LSVDQNTNMYLVLEYVSGGDLFDAIT-QVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPEN 603
            .:.:...:..|::|||.||:|||.|| :....:|....:..|.:...:.|||...|:|.|:||||
  Rat   544 DAFESKNSFTLIMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPEN 608

  Fly   604 LLVKLDEHGNVLELKLADFGLA--CEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILY 666
            :|. :.:.|:  ::|:.|||||  .:..:.|....|||.::|||::.........|:|:.|:|.|
  Rat   609 ILC-VSQTGH--QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITY 670

  Fly   667 ILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILD 731
            :||.|..||:...:.:...|  |::..::|....:..:.:..:|.::.:|..:...|.::...|.
  Rat   671 MLLSGLSPFLGETDAETMNF--IVNCSWDFDADTFKGLSEEAKDFVSRLLVKEKSCRMSATQCLK 733

  Fly   732 HSW 734
            |.|
  Rat   734 HEW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	17/90 (19%)
		DCX	308..396	CDD:214711	15/87 (17%)
		PKc_like	477..734	CDD:304357	76/259 (29%)
		S_TKc	477..734	CDD:214567	76/259 (29%)
Mylk3	NP_001104280.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..258		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..315		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..443		25/121 (21%)
		STKc_MLCK3	477..737	CDD:271094	80/277 (29%)
		S_TKc	485..737	CDD:214567	76/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900