DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17528 and Camk2d

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_036651.1	Gene:	Camk2d / 24246	RGDID:	2263	Length:	533	Species:	Rattus norvegicus

Alignment Length:	262	Identity:	103/262 - (39%)
Similarity:	149/262 - (56%)	Gaps:	8/262 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 YSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHY-IDAEVRVMKKLNHPHIISLIL 540
            |.|...:|.|.|::|.:.....||..||.|||:..|...::|. ::.|.|:.:.|.||:|:.|..
  Rat    14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 78

  Fly   541 SVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLL 605
            |:.:....|||.:.|:||:||:.|.....:||..:...|:.:..::.:.|..||||||:||||||
  Rat    79 SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLL 143

  Fly   606 VKLDEHGNVLELKLADFGLACEV---NDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYI 667
            :.....|  ..:||||||||.||   ....:...|||.|::||:|.:..||..:|:||.|:||||
  Rat   144 LASKSKG--AAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYI 206

  Fly   668 LLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDH 732
            ||.|:|||.  |..|..|:..|.:|.|:||.|.|..:....:|||..||..:|..|.|:.:.|.|
  Rat   207 LLVGYPPFW--DEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKH 269

  Fly   733 SW 734
            .|
  Rat   270 PW 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	102/260 (39%)
		S_TKc	477..734	CDD:214567	102/260 (39%)
Camk2d	NP_036651.1	STKc_CaMKII	12..303	CDD:270988	103/262 (39%)
		S_TKc	14..272	CDD:214567	103/262 (39%)
		Autoinhibitory domain. /evidence=ECO:0000250	283..292
		Calmodulin-binding. /evidence=ECO:0000250	291..301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..375
		CaMKII_AD	380..507	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920