DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17528 and Trio

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001074771.1	Gene:	Trio / 223435	MGIID:	1927230	Length:	3103	Species:	Mus musculus

Alignment Length:	814	Identity:	185/814 - (22%)
Similarity:	293/814 - (35%)	Gaps:	238/814 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GKSTGSLNGVYSITSVTSETKTLES-----------VVTTNSASGSACLSNTPTADHIK-KRIPS 149
            |.|:...:|..|.:|..|.:::..|           ::.:::||..|      .||.:. ...||
Mouse  2316 GGSSSHGSGPSSCSSGPSSSRSRPSRIPQPVRHHPPMLVSSAASSQA------EADKMSGMSAPS 2374

  Fly   150 SRTPTRK---ALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDLTRL--LEENVKIPGAVRTI 209
            ...||..   ||.....:..       .:|:|.:. ...||..|.:.::  :|...|.||:...
Mouse  2375 PSLPTPSSSLALEASLGQPS-------RLPLSGDS-EGHERETEPIPKMKVMESPRKAPGSTSG- 2430

  Fly   210 YNLCGKKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLS----------NLPLSNSRSNSHR 264
                    ||    :||          |.|....|.||.||.          |.|||.:..:...
Mouse  2431 --------TS----QDG----------NTKDARGNLGSLPLGKTRPGAVSPLNSPLSTTFPSPFG 2473

  Fly   265 LAKCRPSSPLKNGLLAGS-------SP--------FP------------------------AC-- 288
            .....|||||:.|   ||       ||        ||                        .|
Mouse  2474 KEAFPPSSPLQKG---GSFWSSIPASPASRPSSFTFPGDSDSLQRQTHRHAAPSKDTDRMSTCSS 2535

  Fly   289 -----------GGGTGNGSPLIASRL---------SDRVTVVHPRIVTLIRSGTKPRRIMRLLLN 333
                       .|..|:.|..|::.|         .|.:.|....:|.::.|.   ::.|.|:..
Mouse  2536 ASEQSVQSTQSNGSEGSSSSNISTMLVTHEYTAVKEDEINVYQGEVVQILASN---QQNMFLVFR 2597

  Fly   334 KRNS---------PSFDHVLTAITQVVRLD-TGYVRKVFTLSGIPVVRL------SDFFGSDDVF 382
            ....         |.|  ||...:.|:..: .|.::|  :.|....:||      .|..|..|..
Mouse  2598 AATDQCPAAEGWIPGF--VLGHTSAVIMENPDGTLKK--STSWHTALRLRKKSEKKDKDGKRDGK 2658

  Fly   383 FAYG----TERINTAEDFKL-------EAEEQRAINVIRKTMRTTGT------TCKGPKPKMPIK 430
            ...|    .|.::.....||       :...:..|.:...|..|..|      .|..||..:..|
Mouse  2659 LENGYRKPREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVFRCRVCGRPKASITWK 2723

  Fly   431 SKKVYPPLVDSEPFKAETTPEDDRHAALLTS--------------------TGMEINELPS---- 471
            ..:             ..|..:|.|.::..|                    |.:.:|::.|
Mouse  2724 GPE-------------HNTLNNDDHYSISYSDIGEATLKIIGVSTEDDGIYTCIAVNDMGSASSS 2775

  Fly   472 -------------------NIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKE 517
                               |....||....:|.|.||:|.|...:.|..:.|.|.::|...|..:
Mouse  2776 ASLRVLGPGSDGIVVTWKDNFDAFYSEVAELGRGRFAVVKKCDQKGTKRAVATKFVNKKLMKRDQ 2840

  Fly   518 HYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHL 582
              :..|:.:::.|.||.::||:.:.:..|:..||||....|.|.|.:.:....:|.:.|   .||
Mouse  2841 --VTHELGILQNLQHPLLVSLLDTFETPTSYVLVLEMADQGRLLDCVVRWGSLTEGKVR---AHL 2900

  Fly   583 G---AAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLY--AVCGTPTYV 642
            |   .|:.|||:..|.|.|:||||:||  |:......:||||||.|.::|...|  .:.|.|.:.
Mouse  2901 GEVLEAVRYLHNCRIAHLDLKPENILV--DQSLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFA 2963

  Fly   643 APEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDG 707
            ||||:|.....|..|.|:.|::.|:||.|..||: .|:.:|...: |....:.||:.|:..:...
Mouse  2964 APEIILGNPVSLTADTWSVGVLTYVLLSGVSPFL-DDSVEETCLN-ICRLDFSFPEDYFQGVSQK 3026

  Fly   708 VRDLIANMLQADPDVRFTSEDILDHSWTIGNKGN 741
            .::.:..:||.||..|.::...|...|.....|:
Mouse  3027 AKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGS 3060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	19/95 (20%)
		DCX	308..396	CDD:214711	20/107 (19%)
		PKc_like	477..734	CDD:304357	84/261 (32%)
		S_TKc	477..734	CDD:214567	84/261 (32%)
Trio	NP_001074771.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SEC14	69..204	CDD:214706
		Spectrin 1	218..338
		SPEC	220..445	CDD:238103
		Spectrin 2	340..446
		SPEC	341..566	CDD:238103
		Spectrin 3	566..672
		SPEC	567..783	CDD:238103
		Spectrin 4	673..784
		SPEC	787..1014	CDD:238103
		Spectrin 5	907..1012
		SPEC	908..1137	CDD:238103
		Spectrin 6	1138..1244
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1651
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1957
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		SH3_Kalirin_2	2559..2617	CDD:212787	11/62 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2643..2666		4/22 (18%)
		I-set	2689..2780	CDD:254352	15/103 (15%)
		Ig	2703..2780	CDD:299845	12/89 (13%)
		STKc_Trio_C	2792..3054	CDD:271015	85/270 (31%)
		S_TKc	2800..3054	CDD:214567	84/262 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900