DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and unc-43

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001255480.1	Gene:	unc-43 / 177921	WormBaseID:	WBGene00006779	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	315	Identity:	110/315 - (34%)
Similarity:	169/315 - (53%)	Gaps:	31/315 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 PKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGN 487
            |.|.:|       ||.||....         :..|::.::        :...:.|.:...:|.|.
Worm    92 PLPLLP-------PPTVDQHYL---------QQLAMMNAS--------TKFSDNYDVKEELGKGA 132

  Fly   488 FAIVFKIKHRQTGHSYALKIIDKNKCKGKE-HYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLV 551
            |::|.:..|:.||..:|.|||:..|...:: ..::.|.|:.:||.||:|:.|..|:.:.:..|||
Worm   133 FSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLV 197

  Fly   552 LEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLE 616
            .:.|:||:||:.|.....:||..:...|:.:..::.|.||.||||||:||||||:.....|  ..
Worm   198 FDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKG--AA 260

  Fly   617 LKLADFGLACEVND--LLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPD 679
            :||||||||.||||  ..:...|||.|::||:|.:..|...:|:||.|:||||||.|:|||.  |
Worm   261 VKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFW--D 323

  Fly   680 NQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            ..|..|:..|.:|.|::|.|.|..:....:.||.:||..:|..|.|::..|...|
Worm   324 EDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPW 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	101/259 (39%)
		S_TKc	477..734	CDD:214567	101/259 (39%)
unc-43	NP_001255480.1	STKc_CaMKII	120..410	CDD:270988	102/263 (39%)
unc-43	NP_001255480.1	CaMKII_AD	548..672	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920