DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and mnk-1

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_871924.2	Gene:	mnk-1 / 174623	WormBaseID:	WBGene00011304	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	143/529 - (27%)
Similarity:	217/529 - (41%)	Gaps:	135/529 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 SPLKNGLLAGSSPFPACGGG--------TGNGSP--LIASRLSDRVTVVHPR--IVTLIRSGTKP 324
            ||.|.|:   ...:.|.|||        |...:|  :..|...|......||  |......|...
Worm    33 SPRKVGI---QHDYSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEATSPRGGIEIGAGGGKMM 94

  Fly   325 RRIMRLLLNKRNSPSFDHVLTA--------ITQVVRLDTGYVRKVFTLSGIPVV-RLSDFFGSDD 380
            ..:.|....:|.:...:.||::        |.:.|..||.:|...|.:....|| |..|.:|.|:
Worm    95 ANLRRHRQRERETYEDEDVLSSSDESSGRPIPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDE 159

  Fly   381 VFFAYGTERINTAEDFKLEAEEQRAINVIRKTMRTTGTTCKGPKPKMPIKSKKV----YPPLVDS 441
                       |.||:..|.|.      :.:.:...|.|.:.|:......|.|.    |..|.|.
Worm   160 -----------TDEDYFDEEEP------VAELLPLGGGTRRVPRTPGRKNSSKCGFFDYYKLTDE 207

  Fly   442 EPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALK 506
            .                                        :|.|.:..|...|..::|..||:|
Worm   208 H----------------------------------------LGSGAYGSVTTCKSIKSGVEYAVK 232

  Fly   507 IIDKNKCKGKEHYIDAEVRVMKKLN-------HPHIISLILSVDQNTNMYLVLEYVSGGDLFDAI 564
            |:||   :|:.|   :..|:::::|       ||:|:.|:...:..||.|||:|.:.||.|...|
Worm   233 IVDK---QGETH---SRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHI 291

  Fly   565 TQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACE-- 627
            .|...|:|.::|.:.:.:..|:.::|..||.|||:||||:|.....|  |..:||.|..||.:
Worm   292 LQRKYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNH--VSPVKLCDLDLASQRP 354

  Fly   628 -------------VNDLLYAVCGTPTYVAPEIL-LEVG----YGLKIDVWAAGIILYILLCGFPP 674
                         ..||...| |:..::|||:: ..||    |..|.|.|:.|:||||:|.|:.|
Worm   355 PQHERHPLSQVASEPDLASPV-GSAEFMAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLAGYAP 418

  Fly   675 F--VAPDNQ------------QEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFT 725
            |  :..|..            |:.||..|..|.||||:..|..|.:..:||::|:|:.||..||.
Worm   419 FQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRFN 483

  Fly   726 SEDILDHSW 734
            ::.||.|.|
Worm   484 ADQILSHRW 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711	22/98 (22%)
		PKc_like	477..734	CDD:304357	97/297 (33%)
		S_TKc	477..734	CDD:214567	97/297 (33%)
mnk-1	NP_871924.2	PKc_like	200..492	CDD:328722	100/340 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010