Protein Alignment CG17528 and DCLK2

DIOPT Version :10

• Sequence 1: NP_001036462.1
• Gene: CG17528 / 3355134
• FlyBaseID: FBgn0261387
• Length: 748
• Species: Drosophila melanogaster
• Sequence 2: NP_001035351.4
• Gene: DCLK2 / 166614
• HGNCID: 19002
• Length: 783
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 272/684 - (39%)
• Similarity: 386/684 - (56%)
• Gaps: 104/684 - (15%)

  Fly   126 NSASGSACLSNTPTADHIKKRIPSS---------RTPT-------RKALRIKFYRNGDRFYPGIT 174
            :|:.||:  |:.|..:.:   |||.         ||.|       :||.:.:|||||||::.|:.
Human    29 SSSGGSS--SSGPKGNGL---IPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLV 88

  Fly   175 IPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIYNLCG-KKITSLDELEDGQSYVCSCNNENF 238
            ..:|::|:|||:.|..:|||.|.:||.:|..|||||.:.| :|:||||||.:|:||||: :||.|
Human    89 FAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCA-SNEPF 152

  Fly   239 KKVEYNTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRL 303
            :||:|.....|..::.:....|.:               |.|.||               :.|.:
Human   153 RKVDYTKNINPNWSVNIKGGTSRA---------------LAAASS---------------VKSEV 187

  Fly   304 SDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIP 368
            .:....:.|::||:||||.|||:.:|:||||:.:.||:.|||.||:.::||:|.|:::.||.|..
Human   188 KESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQ 252

  Fly   369 VVRLSDFFGSDDVFFAYGTERINTA-EDFKLEAEEQRAINVI---RKTMRTTGTTCKGP--KPKM 427
            |..|.||||.||||.|.|.|:...| :||.|:..|.|.:...   ...::.:|:...||  :.|.
Human   253 VTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKS 317

  Fly   428 PIKSKK------VYPPL---VDSEPFKAETTPEDDRHAALL-TSTG---------------MEIN 467
            |...|:      .|...   |:..|....:||:..:.::.. ||.|               ..:|
Human   318 PASVKRGGHYSSAYSTAKSPVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVN 382

  Fly   468 ELP-------------------SNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKC 513
            ..|                   |.:...|.:|::|||||||:|.:...|.||..:|||||||.||
Human   383 GGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKC 447

  Fly   514 KGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIM 578
            .||||.|:.||.:::::.||:||.|:..::..|.::||:|.|.|||||||||..|:::|.....|
Human   448 CGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAM 512

  Fly   579 IRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVA 643
            :.:|..|:.|||.:.||||||||||||| .:.......|||.|||||..|...||.|||||||||
Human   513 VYNLANALRYLHGLSIVHRDIKPENLLV-CEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVA 576

  Fly   644 PEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGV 708
            |||:.|.|||||:|:||||:|.||||||||||.:.:|.||.|||.|::|..|||.|||.:|.|..
Human   577 PEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 641

  Fly   709 RDLIANMLQADPDVRFTSEDILDHSWTIGNKGNE 742
            ::||:.|||.:.:.|.|:..||.|.|...:...|
Human   642 KELISQMLQVNVEARCTAGQILSHPWVSDDASQE 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX1	156..239	CDD:340526	43/83 (52%)
		Ubl1_cv_Nsp3_N-like	309..392	CDD:475130	42/82 (51%)
		Protein Kinases, catalytic domain	477..734	CDD:473864	140/256 (55%)
DCLK2	NP_001035351.4	DCX1_DCLK2	70..154	CDD:340661	44/84 (52%)
		DCX2	193..276	CDD:340589	42/82 (51%)
		STKc_DCKL2	409..667	CDD:271086	140/258 (54%)