DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and DCDC2B

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_001092904.1	Gene:	DCDC2B / 149069	HGNCID:	32576	Length:	349	Species:	Homo sapiens

Alignment Length:	381	Identity:	89/381 - (23%)
Similarity:	147/381 - (38%)	Gaps:	94/381 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 ALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIYNLC-GKKITSL 220
            |.|:..|||||.|:||..:.|:..|:.:.|....::|    ..|:.|.|||.:|..| |..:|:|
Human     8 AKRVVVYRNGDPFFPGSQLVVTQRRFPTMEAFLCEVT----SAVQAPLAVRALYTPCHGHPVTNL 68

  Fly   221 DELEDGQSYVCSCNNENFKKVEY--NTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSS 283
            .:|::...|| :...|.|.|:.|  :.|..|       ..:|       ||...|.....|
Human    69 ADLKNRGQYV-AAGFERFHKLHYLPHRGKDP-------GGKS-------CRLQGPPVTRHL---- 114

  Fly   284 PFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAIT 348
                |.|..|...|..|           |..:.:.|:|........|.|::..|..::.||..:|
Human   115 ----CDGAIGRQLPAGA-----------PSYIHVFRNGDLVSPPFSLKLSQAASQDWETVLKLLT 164

  Fly   349 QVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTAEDFKLEAEEQRAINVIRKTM 413
            :.|:|.:|.|.|:.||.|:|:              :.|.|.:.......:..:|.:.:..:...:
Human   165 EKVKLQSGAVCKLCTLEGLPL--------------SAGKELVTGHYYVAVGEDEFKDLPYLELLV 215

  Fly   414 RTTGTTCKGPKPKMPIKSKKVYPPLVDSEP-------FKAETT------PEDDRHAALLTSTGME 465
                     |.|.:|....:  ||...|.|       .:|:.|      |:..:.:|........
Human   216 ---------PSPSLPRGCWQ--PPGSKSRPHRQGAQGHRAQVTQPSPKEPDRIKPSAFYARPQQT 269

  Fly   466 I---NELPSNIRNTYSL-GRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKE 517
            |   ::||     |.|. ..:||      |:...||:...:.||::.|....:.:|
Human   270 IQPRSKLP-----TLSFPSGVIG------VYGAPHRRKETAGALEVADDEDTQTEE 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	31/89 (35%)
		DCX	308..396	CDD:214711	20/87 (23%)
		PKc_like	477..734	CDD:304357	10/42 (24%)
		S_TKc	477..734	CDD:214567	10/42 (24%)
DCDC2B	NP_001092904.1	DCX	9..87	CDD:176357	28/82 (34%)
		TGS	131..211	CDD:330245	20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..258		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3757
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810