DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and CAPSL

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_006714507.1	Gene:	CAPSL / 133690	HGNCID:	28375	Length:	225	Species:	Homo sapiens

Alignment Length:	213	Identity:	40/213 - (18%)
Similarity:	73/213 - (34%)	Gaps:	55/213 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKVKINSLHCNDAVLSSLQASPSATSPQSVPSKANVVTEASIIEKTNQPHNVQEDNNYNRDCDSP 68
            :|:...:.|..:..:.:.:...:||.|........:...::.|:...:...:.:|:| ||..|..
Human    16 QKMAGTARHDREMAIQAKKKLTTATDPIERLRLQCLARGSAGIKGLGRVFRIMDDDN-NRTLDFK 79

  Fly    69 ESSSSEQDKELDDLRNLHSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSAC 133
            |..     |.|:|.                            :|..|.:.:|.:.......|:.
Human    80 EFM-----KGLNDY----------------------------AVVMEKEEVEELFRRFDKDGNG- 110

  Fly   134 LSNTPTADH----IKKRIPSSRTPTRKALRIKFYRNGDRFYPG-ITIPVSNE--------RYRSF 185
                 |.|.    :..|.|.||  .||.:.::.:|..|:...| |||....|        :|::.
Human   111 -----TIDFNEFLLTLRPPMSR--ARKEVIMQAFRKLDKTGDGVITIEDLREVYNAKHHPKYQNG 168

  Fly   186 ERLFEDLTRLLEENVKIP 203
            |...|.:.|...:|...|
Human   169 EWSEEQVFRKFLDNFDSP 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	15/60 (25%)
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357
		S_TKc	477..734	CDD:214567
CAPSL	XP_006714507.1	EF-hand_7	61..118	CDD:290234	15/96 (16%)
		EFh	63..118	CDD:238008	15/94 (16%)
		EF-hand_7	100..157	CDD:290234	16/64 (25%)
		EFh	101..155	CDD:238008	15/61 (25%)
		EF-hand_7	133..202	CDD:290234	13/54 (24%)
		EFh	133..199	CDD:298682	13/54 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900